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Can a zap to the neck help smokers quit? new trial tests nerve stimulator

NCT ID NCT07487818

Recruiting now Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a handheld device that gently stimulates the vagus nerve in the neck, combined with a nicotine patch, can help people stop smoking. Researchers at Mayo Clinic will enroll 150 motivated smokers who smoke at least 10 cigarettes a day. Participants use the device twice daily and wear a nicotine patch for 12 weeks, with quit rates checked by breath tests.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
non-invasive vagus nerve stimulator plus nicotine replacement patches
What this could lead to
If it works, this could offer a new, drug-free way to boost quit rates for smokers who struggle with cravings.
What could go wrong
This is an early-to-mid-stage trial with only 150 people, so results may not apply to everyone. The device is new for this use, and side effects or lack of benefit are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

nicotine dependence Smoking Smoking Cessation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMOKING CESSATION

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • Mayo Clinic in Rochester

    RECRUITING

    Rochester, Minnesota, 55905, United States

    Contact Email: •••••@•••••

    Contact Email: •••••@•••••

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