New shot could boost opioid recovery, early trial hopes

NCT ID NCT07420283

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 07, 2026 · Updated 7 times

Summary

This Phase 2 trial tests whether adding brenipatide to standard buprenorphine treatment helps people with opioid use disorder stay off opioids longer. About 465 participants will receive either brenipatide or a placebo injection alongside their usual medication. The study measures weeks of abstinence through urine tests and self-reports over up to 144 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: brenipatide (also known as LY3537031)
What this could lead to: If it works, this could provide a new add-on treatment to help people with opioid use disorder stay abstinent longer during early recovery.
What could go wrong: This is an early Phase 2 trial, so results are uncertain. The added benefit over standard buprenorphine alone may be small or none, and side effects of brenipatide are not yet fully known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID-USE DISORDER

Contacts and locations

Locations

Accel Research Sites - Lakeland Clinical Research Unit
RECRUITING

Lakeland, Florida, 33803, United States
Adams Clinical Boston
RECRUITING

Boston, Massachusetts, 02116, United States
Adams Clinical Bronx
RECRUITING

The Bronx, New York, 10461, United States
Adams Clinical Dallas
RECRUITING

DeSoto, Texas, 75115, United States
Adams Clinical Harlem
RECRUITING

New York, New York, 10029, United States
Adams Clinical Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Adams Clinical Watertown
RECRUITING

Watertown, Massachusetts, 02472, United States
Advanced Research for Health Improvement, LLC
RECRUITING

Naples, Florida, 34102, United States
Ark Clinical Research - Fountain Valley
RECRUITING

Fountain Valley, California, 92708, United States
Avera Research Institute - Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57108, United States
Better Years Ahead Medical Center
RECRUITING

Tampa, Florida, 33614, United States
Bioluminux - London
RECRUITING

London, SE6 4LF, United Kingdom
Bioluminux - Southampton
RECRUITING

Southampton, SO15 2AQ, United Kingdom
Bioluminux - Wolverhampton
RECRUITING

Wolverhampton, WV9 5HB, United Kingdom
Bioluminux Clinical Research - Milton Keynes
RECRUITING

Milton Keynes, MK15 0DU, United Kingdom
Biopharma Informatic, LLC
RECRUITING

Houston, Texas, 77043, United States
Boston Medical Center
NOT_YET_RECRUITING

Boston, Massachusetts, 02118, United States
Bradenton Research Center, Inc.
RECRUITING

Bradenton, Florida, 34205, United States
Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Brown University School of Public Health
RECRUITING

Providence, Rhode Island, 02903, United States
CaRe Clinic
RECRUITING

Calgary, T2N 4L7, Canada
Carilion Clinic
RECRUITING

Roanoke, Virginia, 24014, United States
Center on Substance Use and Health (CSUH)
RECRUITING

San Francisco, California, 94102, United States
Centre for Addiction and Mental Health (CAMH)
RECRUITING

Toronto, M6J 1H4, Canada
Comprehensive Treatment Clinic
RECRUITING

Toronto, M4J 1M3, Canada
Greater Manchester Mental Health NHS Foundation Trust
NOT_YET_RECRUITING

Manchester, M25 3BL, United Kingdom
Indiana University Health Neuroscience Center
RECRUITING

Indianapolis, Indiana, 46202, United States
Innovative Research Institute - Port Charlotte
RECRUITING

Port Charlotte, Florida, 33952, United States
K2 Medical Research - Daytona Beach
RECRUITING

Daytona Beach, Florida, 32114, United States
Kelowna Health and Memory Centre
RECRUITING

Kelowna, V1Y 5A8, Canada
Lambeth Drug and Alcohol Treatment Consortium
NOT_YET_RECRUITING

London, SW9 8DG, United Kingdom
Life Arc Research Centers - Miami
RECRUITING

Miami, Florida, 33126, United States
Malton Medical Group
RECRUITING

Mississauga, L4T 4J2, Canada
Maryland Treatment Centers - Avery Road Treatment Center
RECRUITING

Rockville, Maryland, 20853, United States
Maryland Treatment Centers - Mountain Manor Treatment Center
RECRUITING

Baltimore, Maryland, 21229, United States
Med Trust Research
RECRUITING

Courtice, L1E 2J5, Canada
Neuroscience Research Institute - West Palm Beach
RECRUITING

West Palm Beach, Florida, 33407, United States
NextPhase Research Florida - Hollywood
RECRUITING

Hollywood, Florida, 33024, United States
NoesisPharma - Phoenix - East Shea Boulevard
RECRUITING

Phoenix, Arizona, 85028, United States
Ohio Clinical Trials
RECRUITING

Columbus, Ohio, 43212, United States
Old Bank House Hillingdon Drug & Alcohol
NOT_YET_RECRUITING

Uxbridge, UB8 1JP, United Kingdom
Penn Medicine: University of Pennsylvania Health System
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Pillar Clinical Research- Little Rock
RECRUITING

Little Rock, Arkansas, 72204, United States
Providence Care
RECRUITING

Kingston, K7L 4X3, Canada
Queen Elizabeth University Hospital
NOT_YET_RECRUITING

Glasgow, G51 4TF, United Kingdom
Re:Cognition Health - Chicago
RECRUITING

Chicago, Illinois, 60611, United States
Research Works San Juan
NOT_YET_RECRUITING

Guaynabo, 00966, Puerto Rico
Rivus Wellness and Research Institute
NOT_YET_RECRUITING

Oklahoma City, Oklahoma, 73112, United States
SKY Integrative Medical Center/SKYCRNG
RECRUITING

Ridgeland, Mississippi, 39157, United States
St Pancras Clinical Research
NOT_YET_RECRUITING

London, EC2Y 8EA, United Kingdom
St Pancras Clinical Research - Eastbourne
NOT_YET_RECRUITING

Eastbourne, BN23 5UZ, United Kingdom
Surrey and Borders Partnership NHS Foundation Trust
RECRUITING

Chertsey, KT16 9AU, United Kingdom
The Medical Arts Health Research Group
NOT_YET_RECRUITING

Kamloops, V2C 1K7, Canada
UCSF Weill Institute for Neurosciences - Substance Use Disorders Clinic - Mission Bay
RECRUITING

San Francisco, California, 94158, United States
University of Kentucky Chandler Medical Center
RECRUITING

Lexington, Kentucky, 40508, United States
University of Virginia Health System
NOT_YET_RECRUITING

Charlottesville, Virginia, 22903, United States
University of Washington - Harborview Medical Center
RECRUITING

Seattle, Washington, 98104, United States
Woodland International Research Group
RECRUITING

Little Rock, Arkansas, 72211, United States

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