Could a diabetes drug help fight opioid addiction?
NCT ID NCT06651177
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether tirzepatide, a drug used for diabetes and weight loss, can help people with moderate to severe opioid use disorder stay in treatment and use fewer opioids when added to their regular buprenorphine medication. About 310 adults who recently started buprenorphine will receive either tirzepatide or a placebo for 6 months. The goal is to see if tirzepatide improves treatment retention and reduces opioid use.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
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Locations
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Gateway Community Services
RECRUITINGJacksonville, Florida, 32204, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Healthy Minds/Chestnut Ridge
RECRUITINGMorgantown, West Virginia, 26505, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
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IBIS Behavioral Health
NOT_YET_RECRUITINGTampa, Florida, 33605, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Marshall Health
RECRUITINGHuntington, West Virginia, 25701, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Prisma Health
RECRUITINGGreenville, South Carolina, 29605, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ruth M. Rothstein CORE Center
RECRUITINGChicago, Illinois, 60612, United States
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The Gibson Center for Behavioral Change
RECRUITINGCape Girardeau, Missouri, 63703, United States
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University of Utah
RECRUITINGSalt Lake City, Utah, 84108, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37232, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••