Could a diabetes drug help fight opioid addiction?

NCT ID NCT06651177

Recruiting now Disease control Sponsor: T. John Winhusen, PhD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 3 times

Summary

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can help people with moderate to severe opioid use disorder stay in treatment and use fewer opioids when added to their regular buprenorphine medication. About 310 adults who recently started buprenorphine will receive either tirzepatide or a placebo for 6 months. The goal is to see if tirzepatide improves treatment retention and reduces opioid use.

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Conditions

The condition(s) this trial relates to.

follicular lymphoma opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID USE DISORDER, MODERATE OPIOID USE DISORDER, SEVERE OPIOID-USE DISORDER

Contacts and locations

Locations

Gateway Community Services
RECRUITING

Jacksonville, Florida, 32204, United States
Healthy Minds/Chestnut Ridge
RECRUITING

Morgantown, West Virginia, 26505, United States
IBIS Behavioral Health
RECRUITING

Tampa, Florida, 33605, United States
Marshall Health
RECRUITING

Huntington, West Virginia, 25701, United States
Prisma Health
RECRUITING

Greenville, South Carolina, 29605, United States
Ruth M. Rothstein CORE Center
RECRUITING

Chicago, Illinois, 60612, United States
The Gibson Center for Behavioral Change
RECRUITING

Cape Girardeau, Missouri, 63703, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84108, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States

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