Magic mushroom compound could help curb alcohol cravings, new trial hopes

NCT ID NCT06349083

Recruiting now Disease control Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 5 times

Summary

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with therapy can change brain activity and reduce drinking in people with alcohol use disorder. Two hundred participants will receive either psilocybin or a placebo, plus supportive therapy sessions. Researchers will use brain scans and self-reports to see if the drug helps control cravings and improve drinking habits.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: psilocybin
What this could lead to: If successful, this could point toward a new treatment approach for alcohol use disorder that combines a psychedelic drug with therapy to help people reduce heavy drinking.
What could go wrong: This is a mid-stage trial with 200 people, so results may not apply to everyone. Psilocybin can cause intense psychological effects, and the study is focused on brain changes, not yet a proven treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alcohol abuse

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALCOHOL USE DISORDER

Contacts and locations

Locations

NYU Langone Health
RECRUITING

New York, New York, 10016, United States

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