Magic mushroom compound could help curb alcohol cravings, new trial hopes
NCT ID NCT06349083
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with therapy can change brain activity and reduce drinking in people with alcohol use disorder. Two hundred participants will receive either psilocybin or a placebo, plus supportive therapy sessions. Researchers will use brain scans and self-reports to see if the drug helps control cravings and improve drinking habits.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
psilocybin
What this could lead to
If successful, this could point toward a new treatment approach for alcohol use disorder that combines a psychedelic drug with therapy to help people reduce heavy drinking.
What could go wrong
This is a mid-stage trial with 200 people, so results may not apply to everyone. Psilocybin can cause intense psychological effects, and the study is focused on brain changes, not yet a proven treatment.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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NYU Langone Health
RECRUITINGNew York, New York, 10016, United States
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Silver Hill Hospital
RECRUITINGNew Canaan, Connecticut, 06840, United States
Contact