Can a stress hormone explain alcohol relapse?

NCT ID NCT07612631

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study uses brain scans to see how stress-related proteins change in heavy drinkers compared to healthy people. Researchers give a stress hormone (hydrocortisone) and then scan the brain to measure these proteins. The goal is to understand if these proteins play a role in relapse. About 90 people will take part.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
hydrocortisone
What this could lead to
If successful, this could help explain why some heavy drinkers relapse, pointing toward future stress-focused treatments.
What could go wrong
This is a very early, small imaging study, not a treatment trial. It may not lead to any direct benefit for participants.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of Pittsburgh

    RECRUITING

    Pittsburgh, Pennsylvania, 15213, United States

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