New hope for Alcohol-Related liver disease: drug trial targets inflammation

NCT ID NCT06613698

Recruiting now Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 04, 2026 · Updated 2 times

Summary

This study tests a new drug, GSK4532990, in about 393 adults with liver inflammation from alcohol use. The goal is to see if it safely reduces liver stiffness and improves liver function over 52 weeks. Participants receive either the drug or a placebo, and researchers monitor side effects and blood levels of the drug.

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Conditions

The condition(s) this trial relates to.

alcoholic liver disease fatty liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LIVER DISEASES, ALCOHOLIC

Contacts and locations

Locations

GSK Investigational Site
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Chandler, Arizona, 85224, United States
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Phoenix, Arizona, 85006, United States
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Tucson, Arizona, 85712, United States
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Tucson, Arizona, 85715, United States
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Coronado, California, 92118, United States
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Lancaster, California, 93534, United States
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Los Angeles, California, 90033, United States
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Los Angeles, California, 90048, United States
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Pasadena, California, 91105, United States
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Sacramento, California, 95817, United States
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Brandon, Florida, 33511, United States
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Miami, Florida, 33173, United States
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Miami Lakes, Florida, 33016, United States
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Atlanta, Georgia, 30309, United States
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Indianapolis, Indiana, 46202, United States
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Topeka, Kansas, 66606, United States
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Marrero, Louisiana, 70072, United States
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Detroit, Michigan, 48202, United States
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Las Vegas, Nevada, 89106, United States
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New York, New York, 10029, United States
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Chapel Hill, North Carolina, 27514, United States
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Cleveland, Ohio, 44195, United States
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Philadelphia, Pennsylvania, 19014, United States
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Hermitage, Tennessee, 37076, United States
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Arlington, Texas, 76012, United States
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Austin, Texas, 78757, United States
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Dallas, Texas, 75203, United States
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Dallas, Texas, 75390-8565, United States
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Fort Worth, Texas, 76104, United States
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Georgetown, Texas, 78626, United States
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McAllen, Texas, 78503, United States
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San Antonio, Texas, 78215, United States
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Richmond, Virginia, 23219, United States
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Richmond, Virginia, 23249, United States
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Buenos Aires, 1425, Argentina
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Buenos Aires, C1061AAS, Argentina
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Buenos Aires, C1181ACH, Argentina
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Buenos Aires, Argentina
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Ciudad AutOnoma de Buenos Aire, 1118, Argentina
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Ciudad Autonoma de Buenos Aire, C1426, Argentina
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Rosario, 2002, Argentina
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Rosario, S2002, Argentina
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San Miguel de Tucumán, T4000IHE, Argentina
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Adelaide, South Australia, 5000, Australia
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Melbourne, Victoria, 3004, Australia
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Parkville Melbourne, Victoria, 3050, Australia
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Murdoch, Western Australia, 6150, Australia
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Perth, Western Australia, 6000, Australia
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Calgary, Alberta, T2N 4Z6, Canada
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New Westminster, British Columbia, V3L 3W4, Canada
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Vancouver, British Columbia, V6Z 2K5, Canada
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London, Ontario, N6A 5A5, Canada
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Toronto, Ontario, M1S 4T7, Canada
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Toronto, Ontario, M5G 2C4, Canada
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Montreal, Quebec, H2X 0A9, Canada
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Terrebonne, Quebec, J6X 4P7, Canada
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Esbjerg, 6700, Denmark
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Hvidovre, 2650, Denmark
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Odense C, 5000, Denmark
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Angers, 49933, France
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Bobigny, 93000, France
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Créteil, 94000, France
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Lille, 59037, France
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Montpellier, 34295, France
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Rouen, 76031, France
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Bochum, North Rhine-Westphalia, 44892, Germany
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Berlin, 10787, Germany
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Berlin, 13353, Germany
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Kiel, 24105, Germany
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Leipzig, 04103, Germany
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Mainz, 55101, Germany
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Athens, 10676, Greece
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Athens, 11527, Greece
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Athens, 11527, Greece
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Bergamo, 24127, Italy
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Bologna, 40138, Italy
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Messina, 98124, Italy
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Milan, 20122, Italy
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Milan, 20142, Italy
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Milan, 20162, Italy
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Padova, 35131, Italy
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Roma, 00128, Italy
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Roma, 00168, Italy
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Chiba, 286-8520, Japan
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Ehime, 790-0024, Japan
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Gunma, 371-8511, Japan
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Hokkaido, 060-0033, Japan
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Kagawa, 760-0017, Japan
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Kagawa, 761-0793, Japan
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Nara, 634-8522, Japan
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Niigata, 951-8520, Japan
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Osaka, 545-8586, Japan
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Osaka, 564-0013, Japan
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Osaka, 565-0871, Japan
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Saitama, 350-0495, Japan
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Shizuoka, 431-3192, Japan
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Tokyo, 180-8610, Japan
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DF, 14080, Mexico
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Mexico City, 11510, Mexico
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San Pedro Garza García, 66260, Mexico
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Katowice, 40-600, Poland
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Mysłowice, 41-400, Poland
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Warsaw, 00-124, Poland
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Johannesburg, 2193, South Africa
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Soweto Johannesburg, 2013, South Africa
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Ansan, 15355, South Korea
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Bucheon-si, South Korea
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Daegu, 700-721, South Korea
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Seoul, 02447, South Korea
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Seoul, 06351, South Korea
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Seoul, 07061, South Korea
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Seoul, 138-736, South Korea
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Suwon Gyeonggi-do, 442-723, South Korea
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Barcelona, 08003, Spain
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Barcelona, 08035, Spain
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Barcelona, 08036, Spain
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León, 24071, Spain
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Madrid, 28006, Spain
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Madrid, 28007, Spain
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Madrid, 28041, Spain
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Santander, 39011, Spain
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Seville, 41013, Spain
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Valencia, 46014, Spain
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Valladolid, 47003, Spain
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Vigo, 36071, Spain
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Stockholm, SE-141 86, Sweden
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Uppsala, 751 85, Sweden
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Kocaeli, İzmit, 41001, Turkey (Türkiye)
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Diyarbakır, Sur, 21280, Turkey (Türkiye)
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Adana, Yüreğir, 01230, Turkey (Türkiye)
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Istanbul, 34010, Turkey (Türkiye)
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Bristol, BS10 5NB, United Kingdom
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Cambridge, CB2 0QQ, United Kingdom
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Glasgow Strathclyde, G51 4TF, United Kingdom
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Leeds West Yorkshire, LS9 7TF, United Kingdom
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Liverpool, L9 7AL, United Kingdom
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London, NW3 2QG, United Kingdom
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London, W2 1NY, United Kingdom
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Middlesbrough, TS4 3BW, United Kingdom
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Plymouth, PL6 5FP, United Kingdom

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