Substance-related disorder

This study tested whether offering hepatitis C (HCV) treatment right at methadone clinics helps more people get cured compared to sending them to outside specialists. Over 600 adults on opioid addiction therapy took part across 13 clinics in Ukraine. Some clinics provided simplif…

This study investigates whether a daily probiotic supplement containing Lactobacillus bacteria can help reduce alcohol cravings, withdrawal symptoms, and the severity of alcohol use disorder in adult men. Participants take either the probiotic or a placebo for 12 weeks, and resea…

This study tests whether adding a smartphone-based incentive program to standard counseling helps veterans with alcohol use disorder reduce heavy drinking. Participants use a mobile app to submit breath alcohol readings and earn rewards for abstinence. The trial compares this com…

This study tested a treatment called CPT-SMART that combines PTSD therapy, smoking cessation counseling, medication, and financial incentives to help veterans quit smoking. 120 veteran smokers with PTSD were randomly assigned to either the full program or a control group. The goa…

This study tested a program to help people with opioid use disorder stay on their medication after being hospitalized for serious infections like endocarditis or bone infections. Forty adults took part to see if the program was practical and helpful. The goal is to improve long-t…

This study tested whether brief or in-depth counseling could help people living with HIV in Zambia reduce unhealthy alcohol use and improve HIV treatment. 680 adults who were on HIV medication and had hazardous drinking plus mental health or substance use issues took part. Partic…

This study tests whether newborns with neonatal abstinence syndrome (NAS) who receive a high-calorie formula for two weeks gain weight better than those on standard formula. The babies are managed using the Eat, Sleep, Console approach. The main goal is to see how much weight the…

This study tests a 5-week community-based program that teaches protective behavioral strategies to reduce alcohol use in men aged 35–44 with hazardous drinking habits in rural Vietnam. Participants learn to set safe drinking limits, choose nonalcoholic drinks, and plan ahead, wit…

This study compares a fully automated digital screening and brief intervention (e-SBI) to the traditional in-person approach for reducing harmful alcohol consumption. Researchers will enroll over 500 adults from Brazilian public health clinics to see which method works better at …

This study tests a small ear device that gently stimulates nerves to see if it helps people with both PTSD and opioid use disorder stay on buprenorphine therapy. Twenty participants will use either the active device or a placebo for 12 weeks. Researchers will check if they keep t…

This study tests whether a daily capsule containing fragments of a probiotic bacterium (L. rhamnosus) can reduce liver fat and improve blood markers in adults with metabolic dysfunction-associated steatotic liver disease (MASLD). Participants take either the supplement or a place…

This study tested whether offering smokers more frequent and personalized outreach, plus more treatment choices like nicotine patches and text support, helps more people quit compared to standard care. Over 12,000 adult smokers from 10 primary care clinics took part. The goal was…

This study tested whether giving buprenorphine treatment in group medical visits (instead of one-on-one) helps people with opioid use disorder stay abstinent and remain in treatment. Eighteen adults already on buprenorphine but still using opioids took part in weekly 90-minute gr…

This completed trial tested a new approach for opioid use disorder: shining a specific type of near-infrared light on the scalp for just 4 minutes. The idea is to stimulate a healthier side of the brain to reduce addiction. Researchers compared the active light treatment to a sha…

This study tested whether text message reminders and rewards could help people who smoke to stick with their quitline counseling and take their medication. Twenty adults who smoked daily took part. They received a prescription for a stop-smoking drug and were referred to a quitli…

This study tested whether offering small gift cards for quitting smoking helps low-income smokers stay smoke-free. 320 uninsured or Medicaid patients received either standard care (counseling and medication) or standard care plus financial rewards for verified abstinence. The mai…

This study tested different ways to help daily smokers quit by comparing two medications (varenicline and nicotine patches/lozenges), how long to take them before quitting, how long to continue after quitting, and the level of counseling. Over 500 smokers from primary care partic…

This study tests whether virtual reality exposure therapy (VRET) can help men with alcohol use disorder reduce their psychological dependence on alcohol and prevent relapse. Eighty men who have completed detox will be randomly assigned to either VRET or standard treatment. VRET u…

This phase 2 trial tested whether cannabidiol (CBD) can reduce craving and anxiety in 76 adults with opioid use disorder who were already on opioid agonist therapy (like methadone). Participants took CBD or a placebo twice daily for 4 weeks, then all took a higher dose of CBD for…

This small pilot study tested whether giving spironolactone, a drug normally used for heart conditions, could help people with HIV reduce their alcohol use. Twenty-one participants received the drug along with support from a pharmacist and psychiatrist. The study focused on wheth…

This study tested whether a paced breathing app could help women with substance use disorder resist triggers in real time. 77 women used the app whenever they felt a craving or faced a trigger. Researchers tracked substance use and feedback to see if the app helped reduce drinkin…

This study tested whether giving rewards like gift cards can help Native American women quit smoking and lose weight. 125 women who smoked daily and were overweight or obese took part. They earned prizes for staying smoke-free and losing a half to one pound per week. The goal was…

This study tests whether measuring tobacco smoke exposure in children, using a simple blood test, can help parents quit smoking. About 865 parents of young children (12 or younger) who smoke will be enrolled. The goal is to see if this approach, combined with support, leads to mo…

This study tests whether a 15-week aerobic exercise program at the YMCA can help smokers who are highly sensitive to stress quit smoking. Participants work with a personal trainer three times a week and also receive support from a national quitline. The goal is to see if exercise…

This study tested whether a mobile health unit that offers HIV prevention, treatment, and medication for opioid use disorder all in one place helps people who inject drugs stay on treatment. About 447 adults with opioid use disorder took part. The goal was to see if this approach…

This study tests a new behavioral therapy called OPT-A for teenagers who have both substance use problems and mood or anxiety disorders. 140 teens aged 10-17 will receive either OPT-A or standard treatment. Researchers will track substance use and mental health for 18 months to s…

This trial tests whether a team-based approach, including a dedicated nurse care manager, can help primary care clinics provide medication treatment for opioid use disorder. The study involves 12 clinics across five U.S. states, with half using the new approach and half continuin…

This study tested a device called the Bridge, which uses mild electrical pulses to ease opioid withdrawal symptoms. 36 adults with opioid addiction were randomly assigned to get the active device, withdrawal medication (lofexidine), or a placebo. The goal was to see if the device…

This completed trial in Xishui, China, tested a community-based program for 3,571 adults aged 35 and older who were at high risk for COPD and had mental health symptoms. The program included lung function tests, digital mental health support, smoking cessation help, and health ed…

This study tested whether a once-monthly injection of buprenorphine works as well as daily pills to treat opioid use disorder in 140 pregnant women. The goal was to see if the monthly shot could reduce illicit opioid use during pregnancy and after birth. Results help doctors choo…

This study tested whether a personalized talk with a pharmacist could help people take opioid painkillers for a shorter time. 100 adults with non-cancer pain in a hospital rheumatology ward took part. The goal was to see if the pharmacist's advice could keep opioid use closer to …

This study tested a program that combines personalized feedback with text messages to help young adults (ages 18-25) who drink to cope with anxiety or depression. Participants were in a psychiatric partial hospitalization program and drank heavily. The program aimed to reduce dri…

This study looked at whether e-cigarettes or nicotine lozenges help people on methadone switch from smoking tobacco. 183 smokers were randomly assigned to use either JUUL e-cigarettes or nicotine lozenges for 6 weeks. Researchers measured nicotine exposure, lung function, and smo…

This phase 2 trial tested whether the drug sunobinop (V117957) can reduce heavy drinking in adults with moderate to severe alcohol use disorder who want treatment. 209 participants took either sunobinop or a placebo daily for several weeks. The study measured changes in heavy dri…

This study tested two different approaches to help people recently released from jail or prison get connected to care for HIV, hepatitis C, STIs, and opioid use disorder. Over 600 adults took part. The goal was to see which method worked better for starting and staying on treatme…

This study tested three different ways to help people living with HIV stop smoking. Over 670 patients from 13 HIV clinics in Hanoi took part. Nurses either referred patients to a quitline, provided counseling, or offered counseling plus nicotine gum. The goal was to see which met…

This study tested an experimental drug called ADX-629 in 4 adults with moderate alcohol-related hepatitis. The goal was to see if the drug is safe and can help control liver inflammation. Participants had to stop drinking alcohol during the trial. The study is now complete, and r…

This study tested a non-invasive brain stimulation technique called TMS to see if it could help people with alcohol use disorder drink less. 147 adults who wanted to cut back on drinking received TMS and were tracked for 4 months. The goal was to measure changes in drinking days,…

This pilot study looked at whether giving e-cigarettes to adults aged 50 and older who are in treatment for opioid use disorder could help them cut down on smoking. The 36 participants were not trying to quit smoking at the start. Researchers measured how many people switched to …

This study tested a telehealth program for 30 veterans who misuse alcohol and have high blood pressure or other heart risks. The program included four video therapy sessions to reduce drinking, a coaching call to plan heart-healthy steps, and daily text messages for a month. The …

This study looked at different ways to help people with opioid use disorder start treatment. It compared usual care, patient navigation (help from a guide), and patient navigation plus starting buprenorphine right away. The goal was to see which approach gets more people into tre…

This study looked at whether giving a special research e-cigarette to people who are stable on medication for opioid use disorder and smoke daily could help them smoke fewer regular cigarettes. 41 adults who weren't ready to quit smoking were randomly assigned to get the e-cigare…

This study tested a behavioral activation program given as part of a freshman orientation course at the University of Kansas. The program helps students set personal goals and engage in rewarding activities to indirectly reduce alcohol misuse, stress, binge eating, and depression…

This study looked at whether adult smokers who switch to heated tobacco products have lower levels of harmful chemicals in their bodies compared to those who keep smoking regular cigarettes. Over 900 healthy smokers aged 22 to 65 took part. Researchers measured various biomarkers…

This early-phase pilot study tested whether combining topiramate (a seizure medication) with N-acetyl cysteine (a supplement) is safe and tolerable for people with alcohol use disorder. Seventeen adults who were heavy drinkers and seeking treatment took either the combination or …

This study tested whether a culturally adapted therapy called CMAP Plus is practical and acceptable for people with substance use disorder who also self-harm. The therapy combines problem-solving skills with motivational interviewing and was delivered weekly for 12 weeks. The tri…

This early-phase study tested a single nasal spray dose of BPL-003, a psychedelic drug, combined with psychological support in 13 adults with moderate to severe alcohol use disorder. The main goals were to check safety and tolerability, and to explore effects on drinking behavior…

This completed trial tested whether a combination of nutraceutical supplements and psychological support could lower GGT, a liver enzyme, in 197 adults with alcohol use disorder. Participants received liver-supporting supplements and counseling to reduce drinking. The goal was to…

This study tested a noninvasive brain stimulation technique (transcranial random noise stimulation) to see if it could reduce cravings in 225 adults with substance use disorder plus another psychiatric condition like ADHD, bipolar disorder, or schizophrenia. The approach targeted…

This study tested a web-based addiction treatment program that was culturally adapted for American Indians and Alaska Natives. 53 adults in outpatient treatment used the program for 12 weeks. The goal was to see if it helped them stay away from drugs and alcohol and to decide if …

This study tested a mobile phone-based wellness program (WISH) to help veterans with HIV quit smoking. 234 participants were split into two groups: one received the WISH program, the other got standard care (quitline and text support). The goal was to see if the wellness program …

This study looked at whether medical cannabis can help people with chronic pain reduce their use of opioid painkillers. 29 patients who wanted to lower their opioid dose but couldn't afford medical cannabis were given access to it. Over 5 months, doctors tracked their pain levels…

This study tested whether offering medication for opioid use disorder (MOUD) via telehealth to women in jail helps them start treatment after release. 900 women across 9 Kentucky jails took part. Some also got a peer navigator for support. The goal was to see if these services in…

This study tested whether psilocybin, the active ingredient in magic mushrooms, could help people reduce or stop using cocaine. Forty adults who wanted to quit cocaine were given either psilocybin or a placebo (diphenhydramine, an antihistamine) in a controlled setting. Researche…

This study tested whether giving pregnant smokers cigarettes with very low nicotine (0.4 mg per gram of tobacco) helps them smoke less over 12 weeks. Thirty women were randomly assigned to either their usual brand or the low-nicotine cigarettes. The main goal was to see if they s…

This study tested whether offering financial incentives through a smartphone app could help pregnant women stop smoking. 150 women who smoked were randomly assigned to either earn rewards for submitting breath and saliva tests showing no smoking, or to receive standard care. The …

This early study tested a smartphone app that rewards people for staying sober. Participants submitted breath samples three times a day to prove they hadn't been drinking. The goal was to see if this approach is practical and helps people with alcohol use disorder. Only 12 people…

This study tested a program called the Transitions Clinic Network (TCN) for people leaving jail with opioid addiction. The program combines primary care, medication options, and a community health worker to address social needs. Researchers compared this to standard care and foll…

This early-phase study tested whether adding a medication called Auvelity (a combination of dextromethorphan and bupropion) to standard buprenorphine treatment is safe and might help reduce cravings, withdrawal, and negative feelings in people with opioid use disorder. 18 adults …

This study tested whether tolcapone, a drug used for Parkinson's disease, could change how people with both alcohol use disorder and ADHD respond to alcohol and make decisions. 23 adults completed the trial, which involved taking tolcapone or a placebo and then undergoing alcohol…

This study tested two versions of a remote therapy program for teens (ages 14-24) who came to the emergency room for a violent injury. One version was standard, the other used artificial intelligence to adapt the therapy in real time. The goal was to see if the AI version could b…

This study tested whether kudzu, an herbal supplement, can help people who binge drink reduce their alcohol use and related risky sexual behaviors. Researchers enrolled 120 sexually active adults who binge drink and are at high risk for HIV. Participants received either kudzu or …

This study tested a smartphone app called TECH designed to help court-involved teens reduce or stop using marijuana. The app is a private online community where teens can support each other anonymously. Researchers enrolled 60 teens aged 14-18 who had used marijuana in the past y…

This study tested whether a broccoli sprout extract supplement could improve gut health in older adults (50+) who drink at least 8 alcoholic drinks per week and have a low-quality diet. Over 28 days, 40 participants took either the supplement or a placebo. The goal was to see if …

This study tested a blended collaborative care model that uses telemedicine to integrate mental health treatment into primary care at smaller VA clinics serving rural veterans. Researchers enrolled 318 veterans who screened positive for depression, alcohol use disorder, or PTSD. …

This early-stage study tested a new implant that slowly releases naltrexone, a medication used to treat opioid use disorder. The implant is placed under the skin and left for three months. The trial involved 16 healthy adults to check safety and how the drug enters the bloodstrea…

This study tested a culturally adapted relapse prevention program (RPM-08) for people with substance use disorder in Pakistan. 70 male participants in residential rehab either received the program plus usual care or usual care alone. The program consisted of eight weekly group se…

This study tested whether a once-monthly injection (XR-BUP) works as well as daily pills (SL-BUP) for treating opioid use disorder in rural settings. 140 adults with moderate to severe opioid use disorder took part. The goal was to see if the injection is practical and acceptable…

This study tested whether people with opioid use disorder and severe injection-related infections can be safely treated at home with antibiotics and buprenorphine (a medication for opioid use disorder). 71 participants were enrolled. The goal was to see if this integrated approac…

This study tested a special digital pill and smartphone app to help HIV-negative men who have sex with men and who also have substance use disorder take their daily HIV prevention medication (PrEP) consistently. Forty participants took a PrEP pill with a sensor that recorded when…

This study tested whether adding a support person—like a family member or friend—to standard buprenorphine treatment helps people with opioid addiction stay in treatment longer. 439 patients and their support persons took part. The support persons learned CRAFT, a counseling prog…

This completed phase 4 pilot trial tested whether varenicline (Chantix) works better than nicotine patches and lozenges for helping smokers quit. Over 600 smokers who smoked at least 5 cigarettes daily took part. The study measured how many people stayed smoke-free for 7 days, ve…

This study tested a short, motivational counseling session for injured patients who drink alcohol, delivered in the emergency department in Tanzania. Over 600 adults took part, and the goal was to see if the intervention could reduce binge drinking and related harms. The approach…

This early-stage trial tested whether a drug called STP7 (mavoglurant) can safely reduce the physical and psychological effects of cocaine in 21 adults who use cocaine but are not seeking treatment. Participants received either STP7 or a placebo, then were given intravenous cocai…

This study tested whether giving people with alcohol dependence a one-month course of diazepam (40 mg per day) after detoxification could reduce the chance of relapsing into drinking within the next three months. The standard detoxification treatment is usually about one week. Th…

This study tested whether cannabidiol (CBD) can reduce cravings and prevent relapse in people with opioid use disorder who are already taking standard medications like buprenorphine or methadone. Thirty-five participants received either CBD or a placebo for 28 days while in resid…

This pilot study tested whether tailored text messages could help head and neck cancer survivors stop drinking alcohol, which is a major risk factor for cancer recurrence. 126 survivors from a hospital and a VA medical center were randomly assigned to receive either the text mess…

This study looked at whether switching from regular cigarettes to either low or high wattage e-cigarettes changes smoking behavior and reduces exposure to harmful chemicals. 372 daily smokers who were not planning to quit were given e-cigarettes to use freely for 12 weeks, then c…

This study looked at whether providing mental health care to people who inject drugs can improve their mental health and reduce their risk of getting HIV or hepatitis C. Over 500 participants in Haiphong, Vietnam, received free psychiatric consultations, medications, and support …

This study tested two tools to help older adults (65+) on long-term opioid therapy use painkillers more safely. The PainTracker tool helps doctors focus on improving daily function and mental health, while the Opioid Misuse Measure screens for risky opioid use. Researchers studie…

This study tested whether N-acetylcysteine (NAC), a widely available supplement, could help people with both alcohol use disorder and PTSD. 182 adults took either NAC or a placebo daily for 12 weeks, along with weekly therapy. Researchers measured changes in drinking habits, crav…

This study tested a smartphone app designed specifically for women to help them stay engaged with their medication for opioid use disorder. 39 women who had recently started medication treatment were randomly assigned to use the app plus standard care, or standard care alone. Res…

This study tested a therapy called Multisystemic Therapy-Emerging Adults (MST-EA) for young people aged 16-26 with substance use issues and recent arrests. The therapy works with the young adult and their social network at home and in the community to reduce criminal behavior and…

This study tested a comprehensive program to help women involved in the criminal justice system start and stay in opioid addiction treatment. The program included peer support, housing help, overdose training, and transportation or childcare. Half of the 42 women also joined a tr…

This study tested whether a pharmacist-led program could help people leaving jail get treatment for opioid use disorder and prevent overdoses. Participants received overdose training, Narcan nasal spray, counseling, and referrals to medication treatment after release. The goal wa…

This study tested two ways to help primary care doctors prescribe opioids more safely for patients with chronic pain, depression, or anxiety. One approach used an electronic tool that reminded doctors about risk checks and guidelines. The other added a team of a pharmacist, a soc…

This study tested a collaborative care model for people with opioid use disorder and depression, anxiety, or PTSD. 567 adults received medication (buprenorphine-naloxone or naltrexone) along with therapy and support from a primary care team. The goal was to reduce opioid use and …

This phase 3 trial tested whether a single injection of radioactive lipiodol (Lipiocis) into the liver artery could prevent hepatocellular carcinoma from coming back after surgery or ablation. The study enrolled 73 adults with cirrhosis and one or two liver tumors that had been s…

This study tested a mobile app (uMAT-R) designed to help pregnant and postpartum women with opioid use disorder stay on their medication and treatment. 125 women participated in a pilot trial to see if the app was easy to use and helped reduce cravings and improve attitudes towar…

This study tested a 12-month telephone-based nurse care program for 805 adults with depression and signs of opioid use disorder. Participants were randomly assigned to receive nurse support or usual care. The goal was to see if the program could improve treatment for opioid use a…

This study tested whether adding mindfulness-based relapse prevention (MBRP) to standard care helps people with opioid use disorder stay on their medication (extended-release naltrexone) and avoid drug use after leaving a residential treatment program. About 105 participants were…

This study looked at whether pioglitazone, a drug used for diabetes, can help people who recently stopped using cocaine stay off the drug when combined with talk therapy. 61 adults with cocaine use disorder took part. The goal was to see if the drug improves brain health and redu…

This early-stage study tested whether a brief therapy program plus a mobile app could help pregnant and postpartum women stay on their buprenorphine medication for opioid use disorder. Fifteen pregnant women took part, attending therapy sessions and using the app for up to 9 mont…

This study tested two long-acting injectable medications, aripiprazole and paliperidone, in 165 people who use stimulants and have psychosis. The goal was to see if these drugs could better manage psychosis and prevent progression to chronic schizophrenia compared to standard tre…

This study tested a program for 160 HIV-positive fisherfolk in Uganda who were heavy drinkers and struggling to stick with their HIV medication. The program combined individual and group counseling with help opening savings accounts and building social support. The goal was to re…

This study tested whether a single high dose of psilocybin (the active ingredient in magic mushrooms) combined with psychological support could help people with alcohol use disorder drink less. 60 adults in Denmark who were heavy drinkers took part. The main goal was to see if th…

This study tested whether adding the sleep medication lemborexant (Dayvigo) to the standard alcohol craving drug naltrexone helps people with alcohol use disorder and insomnia. Eight adults took either the combination or naltrexone plus a placebo. Researchers measured alcohol cra…

This pilot study tested a 4-week virtual intensive outpatient program for 63 people with moderate to severe alcohol use disorder. The program included group therapy, individual therapy, medication management, and multiple daily breathalyzer checks using facial recognition. The go…

This study tested whether N-acetylcysteine (NAC), an over-the-counter supplement, can help people who use both tobacco and cannabis quit both substances. Fifty-nine regular smokers who also used cannabis took either NAC or a placebo for 8 weeks. Researchers tracked how often they…

This study tested a program called RIMO that helps people who recently survived an opioid overdose get into medication-assisted treatment (MAT). The program uses motivational interviewing and support to encourage people to start and stay on MAT. Researchers worked with first resp…

This completed Phase 4 trial tested a new way to start oral opioid addiction therapy for people who use fentanyl. Participants received medically supervised IV fentanyl until comfortable, then were given tailored doses of methadone or slow-release oral morphine. The study enrolle…

This study tested a new injectable medication called INDV-6001 in 123 adults with moderate to severe opioid use disorder. The goal was to see how the drug moves through the body, if it is safe, and how well people tolerate it. Participants received multiple doses, and researchers…

This study tested whether a gentle brain stimulation technique called tDCS, combined with cognitive training, could improve thinking skills and reduce relapse in veterans with alcohol use disorder. 45 veterans received either real or sham tDCS during cognitive exercises. The goal…

This completed study tested a program called RISE (Resiliency in Stressful Experiences) for young men ages 18-35 leaving state prisons in Florida. The program combines trauma counseling with practical help like housing and job support. Researchers measured whether participants ha…

This study tested whether certain drugs (NNC0194-0499, semaglutide, and cagrilintide) can reduce liver damage and alcohol use in people with alcohol-related liver disease. About 270 adults with a history of heavy drinking took part. Participants received different drug combinatio…

This study tested whether giving adults with chronic pain discounted vouchers for medical cannabis soft-gel capsules could help them reduce their opioid painkiller use. 270 participants were randomly assigned to receive vouchers for placebo or cannabis capsules with different THC…

This pilot study tested a program called 'Nudges to Quit' that sends encouraging messages to people with serious mental illness who smoke. The goal was to see if these messages could help them start smoking cessation treatments like counseling or medication. The study involved 59…

This completed study tested deep brain stimulation (DBS) in just one person with severe, treatment-resistant opioid use disorder. The goal was to see if stimulating brain reward areas could reduce opioid use and improve safety. Because only one participant was enrolled, the resul…

This early-stage trial tested a device called miroliverELAP, which uses a bioengineered liver graft to filter blood outside the body, in 10 adults with acute liver failure. The goal was to check safety and see if it can support the liver for up to 48 hours, giving time for recove…

This study looked at whether giving doctors a simple urine drug test in their office helps people stay on buprenorphine treatment for opiate addiction. About 42 patients starting buprenorphine with their family doctor took part. The goal was to see if these tests improve treatmen…

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce methamphetamine use in people already receiving methadone maintenance therapy. Fifty-five adults with both opioid and methamphetamine use dis…

This study tested a simple, low-cost program to help adults stop using tobacco in busy community health centers in Mumbai, India. Nearly 4,700 participants received either brief advice from trained health workers or usual care. The program used a mobile app and WhatsApp to suppor…

This study tested whether a smartphone app designed for people with serious mental illness can help them quit smoking better than standard methods. Researchers enrolled 343 adults with conditions like bipolar disorder or schizophrenia who wanted to quit. Participants used either …

QuitBet is a digital social game that helps people stop smoking by letting them bet $30 of their own money. Players submit daily breath tests to prove they haven't smoked. Those who succeed split the pot of money from those who fail. This study tested QuitBet in 245 adults who sm…

This pilot study tested a program where trained peer recovery specialists meet regularly with patients starting medication for opioid use disorder. The goal was to see if the program is practical and acceptable to patients. 13 adults took part, and the results will help design a …

This study compared four different smoking cessation programs to see which one works best for underserved smokers who are getting lung cancer screening. Over 3,200 participants from four U.S. health systems took part. The goal was to help them quit smoking for at least six months…

This study looked at whether giving pomegranate seed oil supplements for 24 weeks could help prevent urinary tract infections and pneumonia in people with advanced dementia who are in palliative care. It also checked if the supplement helped reduce or stop antipsychotic medicatio…

This study tested a mobile app designed to help nursing students who smoke change their attitudes and reduce their smoking. Forty-three students used the app, which sent reminders and educational content. Researchers measured changes in smoking intention, attitudes, and decision-…

This study looked at whether smokers who want to cut down can switch to a special research e-cigarette and smoke fewer regular cigarettes. Over 12 weeks, researchers tracked how many cigarettes people smoked and if any quit completely. The goal was to see if e-cigarettes are a he…

This study tested two smartphone apps designed to reduce risky drinking and its effects during the COVID-19 pandemic. One app focused on the drinker, the other on their family partner. About 400 pairs (a drinker and a family member) joined the 12-month study. The goal was to see …

This study tested a program called CareConnect that uses automated phone calls to help cancer patients stop smoking. About 400 cancer patients who smoked took part. The program gave them educational messages and connected them to resources like quitlines or websites. The goal was…

This study tested whether giving small rewards for attending treatment and providing negative alcohol tests helps people with alcohol use disorder stay sober. 74 adults in outpatient treatment were randomly assigned to standard care or standard care plus rewards. The goal was to …

This study looked at whether smokers who quickly respond to nicotine alternatives (like patches, e-cigarettes, or pouches) can keep smoking less or stop entirely for 6 months. 150 healthy adult smokers who reduced their smoking by at least half within 2 weeks were followed. The g…

This study tested a drug called GET73 in 79 people with moderate-to-severe alcohol use disorder who were not seeking treatment. Participants took GET73 or a placebo for 8 days and had MRI scans to see how their brains reacted to alcohol cues. The goal was to see if GET73 could re…

This pilot study tested whether paraprofessional coaches (with or without their own history of substance use) can help young adults aged 18-26 who have been involved with the justice system reduce their opioid and other drug use. The coaches used a combination of prize-based rewa…

This study tested two different doses (100 mg vs 300 mg) of a monthly buprenorphine injection in 785 adults with moderate to severe opioid use disorder. The goal was to see which dose helped people stay in treatment and reduce opioid use. The study also compared a faster versus s…

This study looked at whether adding computer-based cognitive behavioral therapy (CBT4CBT) and peer recovery coaching to standard buprenorphine treatment helps reduce illicit drug use. 92 adults with opioid use disorder were randomly assigned to receive buprenorphine alone, bupren…

This study looked at 240 prisoners with opioid addiction to see if getting a long-acting naltrexone shot at home after release works better than going to a clinic. Participants got one shot in prison and six monthly shots either at a clinic or at their home. The goal was to see i…

This study tested whether ibudilast, a drug that reduces brain inflammation, can help people addicted to methamphetamine. 176 participants took either ibudilast or a placebo for 6 weeks. Researchers used brain scans and thinking tests to see if the drug improved brain function an…

This completed trial tested a workplace program designed to teach young employees (ages 16-24) skills like goal-setting, stress management, and communication. Over 1,100 workers from participating stores took part. The goal was to see if the program could improve job satisfaction…

This study tested a mobile app designed to help gay and bisexual men reduce their methamphetamine use and risky sexual behaviors. The app includes games, lessons, and resources. 226 men who use meth took part. The goal was to see if the app could help them cut back on meth and lo…

This study tested an enhanced tobacco cessation program for retired FDNY firefighters who smoke. The program automatically enrolled participants in counseling, tailored the advice based on their lung scans and breathing tests, and started a quit-smoking medication (varenicline) e…

This study tested a digital program designed to prevent teens from starting to misuse opioids. About 533 high school students who had never misused opioids but were at higher risk took part. The program aimed to increase their understanding of the serious risks of misusing prescr…

This study is developing and testing a smartphone app designed for Native American women to help them avoid pregnancy affected by alcohol. Researchers will gather feedback and pilot test new features with 407 women who are at risk. The goal is to reduce risky drinking and improve…

This study tested a program called PRE-FAIR to prevent opioid and methamphetamine addiction in young parents (ages 16-30) already involved with Oregon's child welfare system. 240 parents who were at risk but not yet addicted were randomly assigned to either the PRE-FAIR program o…

This study looked at whether omega-3 supplements (fish oil) could help pregnant women who smoke have healthier pregnancies and possibly smoke less. About 237 pregnant smokers took either omega-3 pills or a placebo. The goal was to see if the supplements could reduce preterm labor…

This early-phase study tested whether a hormone called progesterone could help new mothers avoid returning to methamphetamine use after childbirth. 34 postpartum women with a history of meth use but currently abstinent took either progesterone or a placebo for 12 weeks. The goal …

This study tested whether a mobile app (GeoPassport), financial incentives, and peer mentor support could help men who have sex with men and transgender women leaving jail access HIV prevention services like PrEP and testing. 233 participants were enrolled and followed for 9 mont…

This study tested whether a new personalized feedback program helps young adults ages 18-25 reduce risky alcohol and drug use. Researchers enrolled 660 participants across the U.S. and measured changes in drinking, drug problems, and readiness to change. The goal is to prevent su…

This study tested a smartphone app designed to help people recovering from alcohol dependence avoid relapse. The app uses a training game to change unconscious habits that make people reach for alcohol. 600 participants used either the active training or a placebo version. The go…

This study tested whether text message reminders can encourage people to keep their opioid pain medication in a safe place and throw away any leftover pills after treatment. About 479 adults who received an opioid prescription took part. The goal was to reduce the chance of these…

This study tested a 45-minute classroom program called UP2UTobacco for 9th graders. The goal was to help students quit or avoid tobacco and nicotine products, including e-cigarettes. Nearly 600 students took part, and researchers checked if the program led to more teens being tob…

This study tested a school-based program called Preventure in 3,900 Canadian teens. The program targets four personality traits linked to substance misuse, aiming to delay or prevent alcohol and drug use. Researchers also measured whether delaying substance use helps protect cogn…

This study tested a web-based simulation to help college students with ADHD prescriptions avoid giving away or misusing their medication. About 250 students from three universities used the program, which taught them how to say no to requests for their pills and how to talk to th…

This study tested a single online session called webCHAT to see if it could reduce impaired driving among teens. 198 adolescents aged 15.5 to 17 who were enrolled in driver education took part. The program aimed to help them make safer choices about alcohol, cannabis, and driving…

This study tested a program for high school students to prevent misuse of prescription drugs like painkillers and sedatives. Over 1,800 teens participated in either the program or standard classes. The program used online lessons and group activities to change attitudes and build…

This study tested whether anti-vaping and anti-smoking ads on social media can prevent tobacco use in young adults ages 18-24. Researchers randomly assigned 2,800 participants to see different amounts of digital ads and measured their vaping and smoking habits over 30 days. The g…

This completed trial tested two school-based programs—Connect and CMCA—to prevent drug and alcohol misuse among 10th graders in rural Cherokee Nation high schools. Over 900 students from 20 schools participated, with some schools receiving the programs and others serving as contr…

This study tested whether a lifestyle physical activity program, using a Fitbit tracker and coaching calls, could help pregnant women at risk for cannabis use reduce their use. Sixteen women who used cannabis at least weekly before pregnancy and had mild depression or anxiety too…

This study tested a pop-up clinic inside a van for women who inject drugs and exchange sex in north Seattle. The goal was to see if offering HIV prevention pills, addiction medications, and quick STI testing in a convenient location would help more women start and stay on these t…

This study tested a simple checklist and peer coaching program for people who inject drugs and are hospitalized with serious infections. The goal was to see if these tools could help start HIV prevention medication (PrEP) and addiction treatment. Sixty HIV-negative adults with op…

This small pilot study tested an 8-week mindfulness and meditation program in 3 adults with substance use disorders. Participants reported lower stress and improved mindfulness after the program. One person stayed sober long-term, while two relapsed within a year. The study shows…

Researchers at Yale University developed a virtual reality game called Invite Only VR to help middle school students learn about the risks of vaping nicotine and cannabis. In the game, players practice refusing offers to vape in realistic social situations. The study tested the g…

This study tested an online parenting program called Family Check-Up Online for rural families where a parent may misuse opioids. 356 parents of young children (18 months to 5 years) took part. The program aimed to improve parenting skills, reduce stress and depression, and preve…

This study tested new ways to prevent opioid misuse and addiction in teens and young adults (ages 16-30) who visited the emergency department. Participants received support starting in the ER and continuing through telehealth after they went home. The goal was to find the most ef…

This study tests whether inhaling medical cannabis three times a day can safely reduce pain in people with diabetic peripheral neuropathy. 122 adults will receive either a low, medium, or high dose of THC or a placebo using a special inhaler. The main goal is to see if pain score…

This study tests four virtual coaching sessions to help veterans with chronic pain use their own cannabis products more effectively. Participants will learn strategies to manage pain and related symptoms. The goal is to see if this coaching improves pain relief and satisfaction.

This pilot study tests whether a short, evidence-based therapy called Written Exposure Therapy (WET) can help reduce PTSD symptoms in adults who are in residential treatment for substance use disorders. Participants complete five guided writing sessions about their trauma. The st…

This study tests a group program that combines mindfulness and art therapy for adolescents with a history of abuse. The program aims to improve how teens see their bodies and reduce feelings of shame. Participants attend sessions that include meditation, creative art activities, …

This study looked at whether adding medical cannabis to a behavioral program helps adults with long-term non-cancer pain lower their opioid dose and manage pain better. 87 participants on stable, high-dose opioids were randomly assigned to either start medical cannabis or not, wh…

This pilot study tested a smartphone app called SiS-H, designed to help people with HIV quit smoking. 66 participants were randomly assigned to use either SiS-H or a standard quit guide app. The study measured how often people used the app and how acceptable it was, rather than d…

This study tested whether a digital mindfulness app is practical and acceptable for people in early recovery from substance use disorders. 36 participants were randomly assigned to standard group therapy alone or standard therapy plus the app for 8 weeks. The main goal was to see…

This study tested whether a simple computer task, called the Approach Avoidance Task (AAT), could help smokers quit. The task aims to change automatic, unconscious thoughts that make people want to smoke. 52 daily smokers who wanted to quit took part. Researchers measured changes…

This study tested whether a computer joystick task that trains people to avoid smoking-related images can help them quit smoking when added to standard care. 96 daily smokers who wanted to quit participated. The training aimed to change automatic, unconscious tendencies to approa…

This study investigates whether an 8-week yoga program can help female smokers manage stress and nicotine withdrawal when trying to quit. Participants attend two 60-minute yoga sessions per week and provide hair and saliva samples to measure stress hormones. The goal is to see if…

This study tests whether adding the blood pressure medication propranolol to cognitive processing therapy (a type of talk therapy) helps people with both post-traumatic stress disorder (PTSD) and alcohol use disorder. About 48 adults aged 18 to 70 with both conditions will receiv…

This study tested whether a drug called isradipine, combined with virtual reality scenes of smoking, could lower cigarette cravings. 78 daily smokers took part. The goal was to see if this approach could help people quit smoking by reducing their urge to smoke when faced with tri…

This study tested whether osteopathic manual therapy (a hands-on treatment) could reduce symptoms of alcohol withdrawal in hospitalized adults. 26 patients were enrolled and their withdrawal symptoms were measured using standard questionnaires. The goal was to see if adding osteo…

This study tested whether a chatbot providing instant messaging support via WhatsApp could help adult smokers in Hong Kong quit. Over 1,000 participants received either brief advice plus chatbot support or brief advice alone. The goal was to see if the chatbot led to higher quit …

This pilot study tested whether an 8-week group therapy program delivered over Zoom could help adults with both chronic pain and opioid use disorder. The therapy, called Emotional Awareness and Expression Therapy (EAET), teaches people to understand and express their emotions as …

This study looked at whether adding a type of talk therapy called prolonged exposure therapy (PET) to standard opioid addiction treatment can help reduce PTSD symptoms. 82 adults with both opioid use disorder and PTSD took part. Some got only addiction treatment, while others als…

This pilot study tested whether a mindfulness program could help veterans with chronic pain and thoughts of suicide. 76 veterans took part to see if the program was acceptable and could reduce pain, depression, and suicide risk. The goal was to improve quality of life and daily f…

This study tested a phone-based counseling program called SBIRT-PM for veterans with chronic pain who were also at risk for substance misuse. Over 1,100 veterans participated, receiving up to four phone calls over 12 weeks to help them engage in non-drug pain treatments and reduc…

This study tested a type of talk therapy called Behavioral Activation (BA) in 10 U.S. veterans who have both alcohol use disorder and PTSD. BA helps people change their daily activities and thinking to reduce drinking and PTSD symptoms. The study compared BA to another therapy ca…

This completed Phase 2 trial tested whether a drug called sunobinop can reduce alcohol cravings in people with moderate to severe alcohol use disorder who want treatment. Forty participants took either sunobinop or a placebo pill daily. Researchers measured cravings using questio…

This early-phase study tested whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) could reduce withdrawal symptoms in 25 adults with opioid use disorder who were gradually reducing their methadone dose. Participants received either real HBOT at two …

This study looked at whether a special sports program, designed with an understanding of trauma, could help teens aged 14-18 with substance use disorder. 120 teens took part, with half joining an 8-week program of sports and group talks, while the other half received no extra act…

This study tested a small, disposable device that gently stimulates nerves in the ear to see if it could reduce the amount of strong painkillers (opioids) needed after open abdominal or pelvic surgery. 286 adults who had surgery for cancer or a liver transplant took part. The goa…

This study tested a type of group therapy called Resilience-Oriented Therapy (RoT) for adults in Rwanda who were struggling with mental health issues like trauma, depression, anxiety, or anger. 427 people took part, and the therapy was tailored to each person's main problem, such…

This study tested a 6-week mindful self-compassion program for homeless women with PTSD and substance use. The program includes meditation, group discussions, and home practices. Researchers compared the program to usual care in 202 women living in a residential drug treatment fa…

This study tested a new medicine called BXCL501 to see if it can safely reduce the unpleasant symptoms people feel when they stop taking opioids. 225 adults with opioid use disorder took part. The medicine was given as a film under the tongue, and researchers measured withdrawal …

This pilot study tests whether a nerve block called the serratus anterior plane (SAP) block can reduce pain and opioid use after heart surgery. Fifty adults having valve or bypass surgery through a chest incision will receive either the numbing drug ropivacaine or a placebo throu…

This study tested two brief, video-based therapies for women who experienced sexual assault and now struggle with PTSD and heavy drinking. One therapy focused on facing trauma memories, the other on building healthier drinking habits. The goal was to see if these short treatments…

This study tested a new type of counseling called behavioral activation problem solving (BAPS) against standard smoking cessation counseling for people with HIV in Botswana. 651 participants were split into two groups to see which approach helped more people quit smoking. The goa…

This completed trial tested a program called REDOCVR for 174 adults with chronic pain. The program combines group education, emotional support, and virtual reality experiences to help people reduce their pain medications. Researchers measured changes in medication use, mental wel…

This study tested whether low-intensity focused ultrasound (LIFU) can safely reduce cravings in people with cocaine use disorder. 25 adults received either real or fake (sham) ultrasound while their brain activity was measured with MRI. The goal was to see if LIFU lowers craving …

This study tested whether a CBD oral solution (Epidiolex) can help manage pain and reduce the need for opioids in 37 adults undergoing double knee replacement. Participants received either a placebo or one of two CBD doses. The goal was to see if CBD could lower opioid use while …

This small pilot study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) could improve cognitive flexibility in people recently detoxified from alcohol. Fourteen adults with alcohol use disorder received either re…

This small pilot study tested a culturally adapted group therapy called Emotional Awareness and Expression Therapy (EAET) in 6 Israeli adults with chronic musculoskeletal pain who also use medical cannabis. The goal was to see if the therapy could reduce pain and improve emotiona…

This study tested a telephone helpline designed to support people with opioid dependence. The helpline offered education, coping strategies, and referrals to medication-assisted treatment. Researchers enrolled 31 participants and measured satisfaction with the service. The goal w…

This study tested whether a 4-week program using active video games (exergames) on the Nintendo Switch could help adults with mental illness feel better and stay motivated. Twelve participants were split into two groups: one played exergames, the other continued their usual routi…

This study tested whether a smartphone app could help people with PTSD quit smoking and avoid starting again. Participants received counseling, stop-smoking medications, and rewards for not smoking, plus the app. The goal was to see if the app made it easier to stay smoke-free co…

This study looked at 626 full-term babies with neonatal opioid withdrawal syndrome (NOWS). Doctors compared two ways of giving medicine: one where babies get medicine at set times, and another where they only get medicine when they show withdrawal signs. The goal was to see which…

This study tested whether a curcumin supplement (NatureU Cheers Friends Curcumin) could reduce hangover symptoms in 12 healthy adult men. Participants took either the curcumin or a standard hangover product before drinking alcohol, then reported their hangover severity the next m…

This study tested a brain stimulation technique called closed-loop tACS in 21 people with methamphetamine addiction. The device uses brain wave patterns to deliver targeted electrical stimulation aimed at reducing cravings. Researchers measured craving levels and impulse control …

This pilot study tested whether people experiencing alcohol withdrawal can be safely treated at home using telemedicine. Thirty adults who wanted to quit drinking received remote monitoring and symptom-triggered medication over three days. The goal was to see if this approach kep…

This study tested a 6-session therapy called Acceptance and Commitment Therapy (ACT) for cancer patients at risk of opioid misuse. 40 adults with cancer and a high score on an opioid risk tool participated. The goal was to see if the therapy was feasible and acceptable, not yet t…

This study tested whether a heart rate variability biofeedback program—using a sensor and smartphone app to guide slow breathing—is practical and helpful for adults in residential treatment for opioid use disorder. Thirty-two participants practiced daily for three weeks. Research…

This study tested two types of therapy for insomnia in 134 people also being treated for alcohol use disorder. The goal was to see if improving sleep could help them stay sober and feel better during the day. Participants received either a standard insomnia treatment or a tailore…

This study tested whether adding a personalized therapy scale to standard treatment helps reduce cravings in people with substance use disorders or behavioral addictions like gambling. 151 adults seeking outpatient care participated. The approach aimed to tailor treatment to each…

This study tested whether a type of brainwave training called neurofeedback could help people with alcohol use disorder feel more confident about staying sober and improve mindfulness. Seventeen adults took part: some received 24 sessions of neurofeedback over 8 weeks, while othe…

This study tested whether a short, trauma-focused therapy called Narrative Exposure Therapy (NET) can help low-income urban teens aged 16–25 who have PTSD from violence and are at risk for substance use. Researchers measured changes in PTSD symptoms and alcohol use. The goal was …

This study tested a combination of a smartphone breathalyzer, a blood alcohol estimator app, and a brief counseling session to help young adults ages 18-25 drink more moderately. Twenty-four participants used the tools for two weeks while drinking. The goal was to see if the tech…

This study tested a video-based program to help university students quit smoking. Participants recorded short videos about their reasons for quitting and received feedback from researchers. The goal was to see if this approach could reduce nicotine dependence and increase motivat…

This study tested a 5-week behavioral therapy for women who experienced sexual assault and use alcohol. The therapy combines writing about the trauma with skills to manage alcohol cravings. Researchers measured changes in drinking habits and PTSD symptoms. The goal is to see if e…

This study tested a structured psychoeducation program for 60 adults with substance use disorder who were under probation supervision. Over six weeks, participants attended weekly group sessions focused on relapse prevention, coping skills, and craving management. The goal was to…

This study looked at whether adding lofexidine to standard buprenorphine treatment can improve symptoms of both PTSD and opioid use disorder in veterans. 84 veterans on stable buprenorphine therapy were enrolled. The goal was to see if the combination reduced opioid use and PTSD …

This study tested a one-day educational workshop for people with chronic non-cancer pain who take high doses of opioids. The workshop, led by a team of doctors, psychologists, and pharmacists, provided information on opioid risks and taught coping strategies. Researchers wanted t…

This study tested whether offering payments for low carbon monoxide readings can help homeless smokers quit. Twenty-five homeless Veterans received nicotine replacement therapy, counseling, and a mobile phone to record their breath tests. The goal was to see if this reward-based …

This study tested an enhanced version of internet-delivered cognitive behaviour therapy (ICBT) for people who misuse alcohol. Researchers added real patient stories and optional resources for common issues like anxiety and depression. 205 adults from Saskatchewan took part, eithe…

This study tested a web-based program that combines cognitive behavioral therapy and pain self-management for people being treated for opioid use disorder who also have chronic pain. The program includes online lessons and daily text surveys to track pain and activity. Researcher…

This pilot study tested whether wearing bright light therapy glasses can improve sleep and reduce cravings in people being treated for opioid use disorder. Twenty-three adults on stable medication-assisted treatment (methadone or buprenorphine) with insomnia used either active or…

This pilot study tested whether taking naltrexone only when needed can help people who want to reduce or stop drinking during Dry January. Nineteen adults who did not have severe alcohol problems took a 50mg pill before drinking or daily as a precaution. The study checked if this…

This study tested a traditional Chinese herbal drink called Tiaozhong-Yiqi Decoction (TZYD) in 80 adults with substance withdrawal syndrome. Half took the herbal medicine twice daily for 3 months plus routine care, while the other half received only routine care. The goal was to …

This study looked at whether a 4-week circuit training program could improve heart and lung fitness in men recovering from drug addiction. Sixty men were split into two groups: one did circuit training (like push-ups, stair climbing, and high knees) three times a week, and the ot…

This study tested whether slowly reducing prescribed opioids (tapering) can help people with long-term chronic pain use fewer painkillers without worsening their pain or quality of life. 140 adults on daily opioids for chronic non-cancer pain were randomly assigned to start taper…

This study looked at whether a short sleep therapy program (BBTI) can improve sleep and help people stay in treatment for substance use disorders. About 83 adults living in a residential recovery program took part. They wore sleep trackers, completed surveys, and did sleep diarie…

This study tested a breathing technique called Holotropic Breathwork to see if it helps people recover from addiction. 25 adults took part, either in a residential treatment program or living in the community. The goal was to see if the practice is safe, acceptable, and might red…

This study tested a smoking cessation program for caregivers of children admitted to American Family Children's Hospital. 23 caregivers received a 20-minute counseling session and used nicotine patches and lozenges for 2 weeks. The goal was to see if caregivers would use the prog…

This study tested whether giving testosterone to older women with chronic back pain and low testosterone could improve pain, physical function, and quality of life. 36 women received weekly injections of either testosterone or a placebo for several weeks. The goal was to see if t…

This study looked at 46 adults having spinal surgery to find out if giving a pain-relieving nerve block (ESP block) before or after surgery works better. The goal was to see which timing reduces opioid use and improves recovery. Results will help anesthesiologists choose the best…

This study tested a mobile app called OPY that helps patients manage pain and safely use opioids after surgery. Over 3,400 adults who had outpatient surgery and received an opioid prescription took part. The app provided daily tips, tracked pain and side effects, and encouraged p…

This study tested two methods to control pain after laparoscopic gallbladder removal: a nerve block (external oblique intercostal block) and injecting pain medicine into the surgical cuts (port-site infiltration). Sixty adults were followed for 24 hours after surgery to see which…

This study tested two remotely delivered programs—mindfulness-based cognitive therapy and internet-based cognitive behavioral therapy—against standard remote monitoring alone for reducing depression and substance use related to COVID-19 stress. 113 adults from a health system par…

This study tested a program to help lung cancer patients stop smoking and avoid starting again. 21 adults with lung cancer who smoked took part. The program included counseling, a web video, and support calls. The goal was to see if the program was easy to use and if patients lik…

This study tested a breathing and meditation program called SKY Recovery in 100 people recovering from substance use disorder at a residential center. Participants either took the program right away or after a delay. Researchers measured changes in emotion regulation, cravings, a…

This early-phase trial tested whether deep transcranial magnetic stimulation (dTMS) targeting specific brain regions is safe and tolerable for people with moderate-to-severe cannabis use disorder. Twelve adults who used cannabis at least four days per week received the stimulatio…

This study tested whether dronabinol, a drug similar to cannabis, can help reduce the need for opioid painkillers after total knee replacement. 114 adults scheduled for knee surgery were randomly given either dronabinol or a placebo before and after their operation. Researchers m…

This study looked at whether an online cognitive behavioral therapy program, called Breaking Free Online, helps people with substance use disorder cut back on their drug or alcohol use. About 200 adults from an outpatient addiction program took part. Some got standard care with g…

This pilot study tested whether adding exercise and pain-focused therapy to residential drug treatment is practical and helpful. 63 adults with opioid use disorder and pain took part. The goal was to see if they would stick with the program and if it could reduce pain, cravings, …

This pilot study tested whether adding protein supplements twice a day could reduce cravings in 28 people hospitalized for addiction. Participants spent one week with protein and one week without, rating their cravings on a simple scale. The goal was to see if a simple dietary ch…

This study tested whether tailored online writing exercises could help sexual minority women, transgender, and nonbinary people who have experienced trauma. The goal was to reduce PTSD symptoms and heavy drinking. 131 participants completed the writing program and were followed f…

This small study tested a structured mindfulness program for adults with both substance use disorder and anxiety. Three participants completed the program to see if it was feasible and could help reduce stress and anxiety. The study focused on emotional awareness and coping skill…

This study looked at whether listening to music can help heart surgery patients need less strong pain medicine. 54 adults who had heart surgery through a cut in the chest took part. The goal was to see if music therapy could lower the amount of opioid painkillers they used.

This study tested whether the drug acetazolamide can improve sleep-disordered breathing in 39 adults with chronic pain who use opioids. Participants took either the drug or a placebo for one week each. The goal was to see if the pill could reduce sleep apnea events as an alternat…

This study tested whether a nerve block (suprazygomatic maxillary nerve block) can reduce pain and the need for strong painkillers in children after tonsil and adenoid removal. 114 children aged 6 months to 18 years took part. The block was given during surgery, and some children…

This study looked at whether listening to music can help lower cravings for opioids when people see drug-related cues. Twenty-eight adults with opioid use disorder, all on stable medication treatment, either listened to their favorite relaxing songs or sat in silence. Researchers…

This study tested whether a nerve block placed near the breastbone after heart surgery can reduce the need for opioid painkillers. 340 adults having heart surgery through a standard chest incision were randomly assigned to receive either the numbing drug ropivacaine or a saltwate…

This study tested whether a single dose of the antibiotic minocycline, given before guided memory recall, could reduce the strength of intrusive memories in people with PTSD or cocaine use disorder. 138 participants took either minocycline or a placebo and then imagined a persona…

This study looked at whether people with chronic pain and opioid use disorder would do art on their own at home, and if it helped their pain and mood. 31 adults tried self-directed artmaking up to four times. Researchers measured how many people stuck with it and whether anxiety,…

This study looked at whether adding a low-dose ketamine infusion to standard pain medication can help people who just had knee replacement surgery. One hundred adults were randomly assigned to get either standard pain relief alone or standard relief plus ketamine through a patien…

This study tested whether cytisine, a plant-based medication, is safe and helpful for quitting smoking in people who also have alcohol use disorder. Twenty adults who smoked daily and wanted to quit took part. The main goal was to see if the drug was well-tolerated and if partici…

This study looked at whether giving a tiny amount of the opioid remifentanil right after surgery could prevent a condition called opioid-induced hyperalgesia, where opioids actually make pain worse. It involved 41 women with breast cancer having breast surgery under total intrave…

This study tested whether transcranial magnetic stimulation (TMS) can help smokers quit by reducing cravings and preventing relapse. 88 adults who had failed previous quit attempts received daily TMS sessions for a week, followed by maintenance sessions. The goal was to see if th…

This study looked at a community-based program in Norway that helps people stop using cannabis. The program combines cognitive therapy and education over about 8 weeks. 102 people took part, and researchers measured changes in cannabis use, mental distress, and well-being right a…

This study tested whether an ultrasound-guided nerve block (Serratus Anterior Plane Block) can improve pain, breathing, and coughing in emergency room patients with rib fractures. Forty adults with confirmed rib fractures received either the nerve block or usual care. Researchers…

This study tested two types of nerve blocks (erector spinae plane block and serratus anterior plane block) to see which provides better pain relief after breast reduction surgery. 80 women received one of the two blocks, and researchers measured how much pain medication they need…

This study tested a special type of talk therapy (cognitive-behavioral therapy, or CBT) delivered over telehealth to help veterans who feel lonely and struggle with substance use. The goal was to see if the program was practical and well-liked by participants. Thirty-six veterans…

This pilot study tested a web-based mind-body program (Web-TIRELESS) in 5 adults with painful upper-limb conditions and risky substance use. Participants completed 4 video sessions at their own pace. The goal was to see if the program was feasible, acceptable, and helpful for bui…

This study tested a behavioral program called IMPROVE to help college students who drink heavily and feel anxious. The program teaches skills to handle anxiety and uncertainty without turning to alcohol. Forty students took part, and researchers checked if the program was easy to…

This study tested a 9-session program that uses cognitive-behavioral techniques to help people living with HIV quit smoking by reducing anxiety and depression. 131 daily smokers who were motivated to quit took part. The goal was to see if the program led to more people staying sm…

This study created and tested a program to help teens and young adults (ages 14-21) who vape or smoke quit while they are in the hospital. 144 participants took part, and the program focused on helping them stop for at least 30 days. The goal was to see if this hospital-based sup…

This study tested whether a non-invasive brain stimulation technique called theta burst stimulation (TBS) could help reduce cravings and improve symptoms in people with methamphetamine use disorder. Twenty-two adults in Indonesia who had not yet received treatment were given TBS …

This study looked at whether adding a brief writing therapy called Written Exposure Therapy (WET) to a standard 28-day residential addiction program helps veterans with both PTSD and substance use disorders. Fifty-six veterans were randomly assigned to either standard care alone …

This study tested whether real-time brain scans (fMRI) could help 21 adults with alcohol use disorder learn to control their cravings. Participants practiced shifting their brain activity toward future goals instead of alcohol. The goal was to see if this mental training could re…

This study tested two methods to control pain after major abdominal surgery: a spinal injection of morphine and a newer nerve block technique. The goal was to see which provides better pain relief with fewer side effects. 56 adults participated, and the study measured how much ex…

This study tested whether a therapy called dialectical behavior therapy (DBT) is helpful and acceptable for teens aged 14–17 with fetal alcohol spectrum disorders (FASD). Nine teens and their caregivers took part in a program that included individual therapy, group skills trainin…

This study tested whether an online program for insomnia (called SHUTi) could help heavy drinkers reduce their alcohol use. 113 adults who drank heavily and had trouble sleeping took part. The goal was to see if improving sleep would also lead to less drinking and fewer binge epi…

This study tested whether peer-led therapy sessions could ease depression and anxiety in people recovering from opioid use disorder in rural areas. Forty adults receiving medication for opioid use disorder took part, with some getting extra support from a certified peer specialis…

This study tested whether a non-invasive brain stimulation technique called rTMS could reduce tobacco cravings in heavy smokers who had already failed multiple quit attempts. 39 highly nicotine-dependent adults received either real or fake rTMS to a brain region linked to craving…

This study tested a walking program for veterans with opioid use disorder and chronic pain. Sixty veterans receiving medication for opioid addiction took part. The program included pain education and a step-by-step walking plan using a pedometer. The goal was to see if this appro…

This study tested a life-skills training program for 45 men aged 20 to 50 recovering from substance use disorders. The goal was to see if the program could improve their self-efficacy, or confidence in handling daily challenges. Participants completed a structured program after d…

This study tested whether adding virtual reality (VR) to standard smoking cessation treatment helps people quit. 74 smokers who wanted to stop received nicotine patches and either usual counseling or VR-enhanced therapy. The goal was to see if VR could reduce cravings and improve…

This study tested whether taking melatonin for three nights before wisdom tooth surgery could lower pain and the need for pain medication afterward. Sixty adults aged 18-35 took either melatonin or a placebo before their surgery. Researchers measured how many pain pills they used…

This study tested how different warning labels (pictorial vs. text-only) and flavor descriptors (sweet vs. none) on little cigar and cigarillo packages affect people's attention and emotional reactions. Researchers used eye tracking and skin sensors on 90 adult tobacco users. The…

This completed study looked at how a person's neighborhood environment might influence drug use, addiction, and whether they seek treatment. Over 1,600 adults from Baltimore took part, including people who never used drugs, past users, and current users. Researchers collected hea…

This study looked at 23 adults going through alcohol detox to see how the bacteria in their mouth and gut change over time. Researchers collected stool and mouth samples along with diet and mood questionnaires. The goal was to better understand the link between gut bacteria, anxi…

This completed early-phase study looked at how opioid use disorder changes the way people make decisions. Twelve adults with moderate to severe opioid use disorder completed gambling tasks and had brain scans while receiving oxycodone, placebo, or remifentanil. The goal was to un…

This study follows adults in Zambia who have both HIV and chronic hepatitis B to track liver health over up to 10 years. Researchers aim to understand how current HIV treatments affect hepatitis B and liver damage, and to identify factors that lead to serious outcomes like liver …

This study aims to create and improve cognitive tasks used during functional MRI scans to better understand how drugs affect the brain. It involves 525 healthy volunteers, including both drug users and non-users, aged 18 to 65. Participants perform tasks like memory tests or reac…

This completed study looked at how genes influence addiction and related behaviors. Researchers collected blood samples and had 847 adults (healthy volunteers, smokers, drug users, and people with psychiatric disorders) complete questionnaires and computer tasks. The goal was to …

This study tested whether portable devices like PDAs and GPS units can give a more accurate picture of stress and drug use as it happens. About 373 adults in treatment for heroin addiction carried these devices for 16 weeks, recording drug use and stress levels. The goal was to s…

This study tests whether suvorexant (Belsomra), a sleep medication, can lower brain activity linked to cannabis cravings. Twenty adults who use cannabis daily will take the drug for 14 days and undergo brain scans before and after. The goal is to see if the medication reduces the…

This study tested a harm reduction program designed specifically for Black adults who misuse opioids or stimulants. 63 participants completed surveys before and after the program to see if their knowledge, confidence, and willingness to use overdose prevention techniques improved…

This study tested whether doctors can use simple decision guides to better manage opioid misuse behaviors in patients on long-term opioid therapy for chronic pain. Researchers worked with 49 clinicians at community clinics to see if the guides were easy to use and helpful. The go…

This study used brain scans to see if heavy drinking causes inflammation in the brain and how that affects memory and thinking. 74 adults aged 30-75, including heavy drinkers and healthy volunteers, had PET and MRI scans along with thinking tests. The goal was to measure brain in…

This study looked at how three psychological treatments—cognitive therapy, mindfulness meditation, and behavioral activation—might help adults with chronic pain reduce their use of opioid medications. Researchers enrolled 91 people with chronic pain who were at risk of opioid mis…

This study looked at how sleep quality and beliefs about sleep affect the risk of relapse in people recovering from alcohol dependence. Researchers followed 198 adults as they left inpatient rehab and returned home, measuring sleep with questionnaires and activity monitors. The g…

This completed study looked at how opioid use disorder changes dopamine signaling in the brain. Researchers used PET and MRI scans to compare people with opioid use disorder (some on medication, some not) to healthy volunteers. The goal was to understand differences in dopamine r…

This study explored whether experiencing subtle racial slights (microaggressions) makes Latinx smokers want to smoke more or makes it harder to quit. Thirty daily smokers who identified as Hispanic or Latino took part. Researchers measured their smoking behavior, withdrawal sympt…

This study tested a computer-assisted method for people to self-administer alcohol intravenously, aiming to achieve precise blood alcohol levels for research. 229 healthy volunteers aged 21-45 took part in sessions where they could give themselves alcohol infusions using a comput…

This study looked at how nicotine affects brain activity and genes in smokers and non-smokers. Researchers used brain scans and genetic tests to understand why some people find it harder to quit smoking. The goal was to find biological markers that could predict quitting success …

This study tested a culturally tailored mental health training called First Face for Mental Health in seven Tribal nations. Over 550 participants completed surveys before and after training to see if it increased knowledge, confidence, and ability to help during a mental health c…

This study looks at 65 veterans with PTSD who use cannabis frequently. Researchers want to see if reducing cannabis use improves their daily functioning, mental health, and quality of life. No treatment or drug is given—participants simply report their cannabis use and well-being…

Sleep problems affect up to 90% of people with alcohol dependence and often lead to relapse. This study tests whether a short questionnaire called the Short Sleep Index (SSI) can reliably measure sleep quality compared to a longer, standard sleep questionnaire. Researchers will a…

This study looked at 180 people with liver cancer (hepatocellular carcinoma) who also had cirrhosis caused by either fatty liver disease or alcohol use. Researchers compared immune cells and gut bacteria in the liver to understand why cancer develops. The goal was to gather knowl…

This completed study in Norway looked at how opioids like morphine, oxycodone, and fentanyl affect patients' mood and pain right before surgery. Over 1,000 healthy adults scheduled for day surgery answered questions about anxiety, relaxation, and pain after receiving a small dose…

This study from Yale University looked at how menthol flavor in e-cigarettes affects smoking behavior and nicotine levels in people who smoke menthol cigarettes. Fourteen adult smokers participated in lab sessions where they used e-cigarettes with menthol or non-menthol flavor. R…

This study tests whether recalling a positive memory can improve mood and decision-making in 80 adults recovering from methamphetamine use disorder. Participants will do computer tasks and brain scans before and after remembering a happy event or a neutral memory. The goal is to …

This study tested whether a 10-week recovery program, co-led by a peer with mental illness and a professional, is feasible for people with mental illness in Taiwan. Twenty participants completed the program, which focused on recovery concepts, strengths, and goal setting. Researc…

This study looked at how much intravenous (IV) medication is wasted in intensive care units (ICUs) across France. Researchers measured the amount of prepared but unused drugs thrown away, which can harm the environment. Over 1,000 patients took part, and the goal was to find ways…

This study tested a program designed to make medication for opioid use disorder more culturally appropriate for American Indian and Alaska Native communities. Researchers worked with four healthcare sites to help them better support patients starting and staying on these medicati…

This study looked at how much injectable drug is prepared but not used in operating rooms across France. Over 3,700 patients were included. The goal was to measure waste and find ways to reduce it, helping the environment and improving healthcare practices.

This study tested a brief digital alcohol intervention for smokers who drink heavily. Participants enrolling in a smoking cessation program through an online portal were offered the intervention if they scored high on a drinking questionnaire. The main goal was to see how many pe…

This study looked back at the records of 652 patients who were seen in the emergency department of a French hospital and then referred to a special addiction liaison team. The goal was to understand the social and medical backgrounds of these patients. The findings could help hos…

This study followed 326 adults in Zambia with chronic hepatitis B for up to 5 years. Researchers tracked how the virus behaves, how many patients need treatment, and how many develop serious liver problems like cirrhosis or liver cancer. The goal was to better understand the dise…

This study looked back at the medical records of 27 patients with alcoholic hepatitis or sudden liver failure who received a treatment called MARS (a type of dialysis that cleans the blood). The goal was to see if MARS helped them survive without needing a liver transplant. Resea…

This completed study looked at 59 men who have sex with men and use methamphetamine. Researchers used a program that gives rewards for drug-free urine samples to help them cut back. They measured inflammation in the rectum and tracked STI/HIV risk behaviors over 8 weeks. The goal…

This study investigates whether chronic cannabis use impairs contrast sensitivity — the ability to see objects clearly against their background, especially when they are moving. Researchers will compare three groups: cannabis addicts, tobacco-only smokers, and non-smokers. Partic…

This study looked at whether opioid use disorder and non-fatal overdoses cause a harmful protein called tau to build up in the brain. Researchers used special PET/CT scans on 12 adults, including those with opioid use disorder and healthy volunteers. The goal was to understand lo…

This completed early-phase study at Yale University tested how different doses and delivery rates of IV nicotine affect its abuse potential and its ability to reduce smoking urges. Twenty daily smokers received low and high doses of nicotine at various speeds. The goal was to bet…

This study looked at whether chewing gum before eating ice cream affects how much people eat. Twenty normal-weight adults who liked mint chocolate chip ice cream took part. They either chewed mint, cinnamon, or no gum before a computer task where they earned ice cream. The main g…

This study looked at whether combining two existing drugs—duloxetine (an antidepressant) and methylphenidate (an ADHD medication)—could reduce the desire to drink alcohol in people with alcohol use disorder. Nineteen adults who were not seeking treatment participated in a lab set…

This study looked at how nalmefene, a drug that blocks opioid receptors, changes brain activity and drinking behavior in heavy drinkers. Thirteen healthy heavy drinkers took nalmefene or a placebo and had brain scans while seeing alcohol-related cues. They also could self-adminis…

This study tested a training program for prenatal healthcare providers to help them use medication-assisted treatment (MAT) for opioid use disorder during pregnancy. Researchers looked at data from over 1,000 patients to see if the program increased use of MAT and improved health…

This study tested two methods to encourage COVID-19 testing among people who use opioids: having friends refer others (chain referral) and using trusted community members (credible messengers). About 500 people took part. The goal was to see which method got more people tested an…

This study tested a computer tool designed to help emergency room doctors follow best practices for treating opioid use disorder. Researchers looked at whether the tool increased the use of standard assessments and buprenorphine treatment. The study involved 267 adults with moder…

This completed study surveyed over 1,500 adults in Nyakabare Parish, Uganda, to learn how people perceive tobacco and alcohol use in their community. Participants answered questions about how often they think others smoke or drink. The goal was to understand perceived norms, whic…

This completed study examined how African American and white male smokers respond to stress and how that affects their smoking habits. Researchers used a psychological stress test and measured daily cortisol patterns to understand biological differences. The goal is to learn why …

This study combined brain imaging with real-world data from mobile devices to explore how addiction affects the brain. Researchers scanned the brains of 107 people with alcohol, cannabis, or nicotine dependence, along with healthy controls. They also tracked cravings and daily fu…

This completed study followed 1,681 people with steatotic liver disease (fatty liver) in Germany to observe how the condition progresses over time. Researchers measured liver stiffness, inflammation, and tracked whether participants developed heart problems or tumors. The goal wa…

This study looked at how Alcoholics Anonymous (AA) helps people with alcohol use disorder reduce their drinking. Researchers tracked 192 adults daily for six months to see which AA activities—like building social support or spiritual practices—led to fewer drinking days. The goal…

This study looked at brain activity in pregnant women with opioid use disorder who were taking medication therapy. Researchers compared their brain scans to those of healthy pregnant women to see if there were differences. The goal was to learn more about how the body processes t…

This study looked at how different labels on vaping devices (like 'contains nicotine' or 'high potency') affect teens' interest in trying them, their views on health risks, and what effects they expect. Over 3,000 high school students viewed images of vaping devices with various …

This study looked at whether changes in a person's voice can help detect opioid use in people being treated for opioid use disorder. Researchers collected voice samples from 41 patients and used machine learning to find patterns linked to opioid intoxication or withdrawal. The go…

This study used artificial intelligence to analyze personality and behavior data from 155 adults in residential treatment for substance use disorder. The goal was to find hidden subtypes of addiction that could lead to more personalized treatment. No treatment was given; the stud…

This study tested whether a mobile app could help people on probation or parole who are receiving treatment for substance use disorder. 31 adults used the app alongside their usual care. Researchers measured how easy the app was to use and how satisfied participants were with it.

This study looked at how thinking skills and brain activity differ in people who self-harm compared to those who don't. Researchers interviewed 316 adults and gave them thinking tests, with some also having brain scans. The goal was to better understand self-harm to help create m…

This study looked at how opioid maintenance therapy affects sensation, balance, walking, posture, and reaction time in people with opioid use disorder. Researchers compared 80 adults on buprenorphine/naloxone therapy to healthy individuals. They measured things like foot sensatio…

This observational study looked at how legal cannabis use changes alcohol drinking habits, gut bacteria, and brain function in people who regularly use both alcohol and cannabis. 77 heavy drinkers who also smoke cannabis took part, providing blood and stool samples and completing…

This study tested whether a training program called Modeling to Learn (MTL) helps clinic staff improve how many veterans start and finish evidence-based treatments for PTSD, depression, and opioid use disorder. The program uses computer simulations to let staff try out changes to…

This study tested whether hands-on training could help people convicted of driving under the influence (DUI) better understand the risks of drinking alcohol. A total of 112 participants took part. The goal was to see if this training could reduce binge drinking and cravings.

This study looked at how different types of cannabis affect memory and brain waves in 96 healthy adults who use cannabis regularly. Participants did a memory task after smoking cannabis and again on a sober day, while their brain activity was recorded with EEG. The goal was to se…

This study looked at how a specific way of thinking, called high-level construal (focusing on the big picture), affects smoking habits. Researchers studied 300 low-income adults aged 25-55 who wanted to quit but had failed before. They used brain scans and surveys to see if this …

This study looked at how the supplement n-acetylcysteine (NAC) affects brain glutamate levels and drug cravings in 12 people who use both opioids and cocaine. Participants were given either NAC or a placebo while on a steady dose of hydromorphone, and then underwent brain scans a…

This study looked at how two hormones that rise during pregnancy—estradiol and cortisol—affect the way the body breaks down THC, the main active ingredient in cannabis. Fourteen healthy women of childbearing age took part. Researchers measured THC levels in the blood after taking…

This study tested a special parenting program (mABC) for pregnant women recovering from opioid addiction. 174 mothers and their babies took part. The program focuses on helping mothers be more sensitive and nurturing, which could improve the baby's emotional and physical developm…

This study involved 24 adult smokers who used three different nicotine products: a tobacco-free nicotine stick, a heated tobacco stick, and regular cigarettes. Researchers measured how much nicotine entered the blood and how the body processed it. The goal was to understand the d…

This study looked at how the price of nicotine pouches affects whether people choose them over cigarettes. Researchers surveyed over 1,300 tobacco users online to see how much they would use pouches at different price points. The goal was to understand if nicotine pouches could b…

This study tested a smartphone app called CampusGANDR that uses a game about college life to give students personalized feedback on their drinking habits. Over 1,100 first-year college students in California and Texas played the game for 12 weeks. Researchers measured changes in …

This study looked at how hospital doctors, nurses, and social workers feel about treating opioid use disorder (OUD) while patients are in the hospital. Researchers surveyed 400 healthcare workers across 12 hospitals in Colorado. The goal was to understand current practices and se…

This study looked at whether using regular patient surveys to guide treatment can help people with opioid use disorder stay in treatment and stop using opioids. Researchers worked with 35 clinic leaders and providers to train them on this approach. They compared patient attendanc…

This study followed nearly 5,000 U.S. teenagers from 10th grade into their early twenties to track how their health behaviors—like diet, exercise, substance use, and driving—changed over time. Researchers collected surveys, genetic samples, and neighborhood data to understand wha…

This study looks at how alcohol use disorder (AUD) might reorganize the way the brain links words and ideas. Researchers will compare 30 AUD patients and 30 healthy controls using word-association tasks and brain tests. The goal is to see if these mental patterns can help predict…

This study tested whether a drug called SXC-2023 interacts with cocaine in the body. Nineteen adults who use cocaine but were not seeking treatment took part. Researchers measured side effects and vital signs like heart rate and blood pressure after giving cocaine. The goal was t…

This study looked at how smoking marijuana with different levels of THC affects alcohol cravings and drinking in people who are heavy drinkers and also use marijuana. 157 participants were given either a high-THC, moderate-THC, or placebo marijuana cigarette, then their alcohol c…

This study tested a mobile app called App for Independence-O (A4i-O) designed to support people with opioid use disorder. Fourteen adults used the app for one month while receiving outpatient treatment. The goal was to see if the app works well and is easy to use, not to measure …

This study tested a group well child care program for mothers in treatment for opioid use disorder and their infants. Instead of standard one-on-one checkups, mother-infant pairs attended group visits together from 1 to 18 months of age. The goal was to see if this approach impro…

This study looked at how the brains of people with alcohol use disorder respond to pictures of social situations and alcohol. Researchers used MRI scans to measure brain activity and tested whether a technique called neurofeedback could help people control their cravings. The stu…

This study involved 440 daily smokers and dual users (smokers who also vape) to understand how price changes affect their choices between cigarettes and other nicotine products like e-cigarettes, nicotine pouches, and heated tobacco. Participants completed a simulated shopping ta…

This study tested a program called Recovery Bridge, where trained peer specialists (people with lived experience of mental illness) helped veterans leaving a psychiatric hospital connect to outpatient care and community life. Fifteen veterans took part to see if the program was f…

This study tested a computer alert that pops up when a doctor prescribes an opioid or sedative, reminding them to check Colorado's prescription drug monitoring program (PDMP). The goal was to see if the alert helps doctors follow state law and reduce risky prescribing. Researcher…

This study tested whether a coaching program for primary care doctors at one VA clinic could improve care for veterans with unhealthy alcohol use. The program aimed to help doctors offer more counseling, medications, and referrals to specialty treatment. Researchers tracked chang…

This study looked at whether a simple slow-breathing exercise can help binge drinkers control their reactions to alcohol-related images and improve their ability to say no. One hundred binge drinkers completed tasks measuring brain activity and attention after either slow breathi…

This study tested a mobile app called WisePath designed to help adults who are thinking about suicide and may also misuse alcohol. Over 12 weeks, 127 participants either used the WisePath app or received standard self-help resources. Researchers measured changes in suicidal thoug…

This study looked at 10,000 older adults (age 60+) with fatty liver disease to find out what increases their risk for serious liver problems like scarring, cirrhosis, or liver cancer. Researchers used medical records and yearly check-ups to build a computer model that predicts th…

This completed Phase 1 study looked at how marijuana and an opioid drug influence each other's use in healthy adults aged 18-50 who had experience with both substances. Eight participants lived at a research unit for about 6.5 weeks and could earn doses of each drug under control…

This study tested a digital version of a family training program called CRAFT. It was designed to help concerned family members (called CSOs) encourage a loved one with opioid use disorder to enter treatment. 45 adults who had a loved one struggling with opioid use participated. …

This study looked at 106 people admitted for addiction treatment at Assiut University Hospital. Researchers collected information on their personal background, drug use patterns, and personality traits. The goal was to identify trends that could help improve addiction care and pr…

This study looked at how pain influences opioid cravings in 89 adults with opioid use disorder and chronic pain. Participants attended a brief education session and then had their pain response and cravings measured. The goal was to better understand the connection between pain a…

This study looked at how consistent FibroScan, a non-invasive device that measures liver stiffness and fat, is when used by different operators on different days. 108 adults with fatty liver or alcohol-related liver disease had multiple scans and blood tests over two visits. The …

This study tested whether an anti-stigma training program for healthcare providers improves attitudes toward people with mental illness or substance use problems. About 485 staff and clients from six health centers took part, with three centers receiving the training and three no…

This study explores the link between gut bacteria and alcohol use disorder (AUD). Researchers compared gut microbiota in three groups: current heavy drinkers with AUD, people with AUD who have been abstinent for at least 4 weeks, and healthy moderate drinkers. Participants provid…

This study looked at the best ways to bring FDA-approved digital treatments (reSET and reSET-O) for opioid and other substance use disorders into primary care clinics. Over 18,000 adults who screened positive for substance use took part. Researchers tested whether health coaching…

This study looked at how a single dose of methamphetamine affects the HIV virus in people who are already on effective HIV treatment. Fourteen HIV-positive adults with no history of meth use took part. The goal was to see if meth causes the virus to become more active and increas…

This completed study looked at how regular cannabis use affects brain health and thinking skills in people with HIV and those without. Researchers used brain scans, blood and spinal fluid tests, and thinking tasks to compare 276 participants. The goal was to understand the combin…

This study looked at whether a short, video-based parenting program called THRIVE could work for mothers with substance use disorder who are getting care at a special clinic. Nine mothers took part to see if the program was easy to use and helpful. The goal was to gather informat…

This study tested a digital toolkit designed to help leaders in child welfare and substance use treatment agencies choose partners and build effective collaborations. Nine implementation support professionals in Ohio used the guide and rated how acceptable, appropriate, and feasi…

This study screened nearly 7,000 volunteers to find people who could take part in future research on drug addiction and its effects on the brain and body. Participants completed phone and in-person interviews, medical exams, and lab tests. No treatment or clinical care was provid…

This study looked at how often insomnia occurs in people hospitalized for psychiatric conditions. Researchers checked 427 patients at 11 hospitals in Switzerland and Germany. They also explored whether age, gender, or type of disorder made insomnia more likely.

This small, early-phase study tested whether a single dose of sedatives like ketamine, midazolam, or dexmedetomidine could reduce cigarette cravings and smoking in 20 daily smokers. Participants received one of these drugs or a placebo (saline) and reported their cravings, withdr…

This study looked at how nicotine is absorbed and affects the body when using a standardized research e-cigarette compared to a person's usual brand e-cigarette. Thirty-two regular e-cigarette users participated in a crossover study where they used both types. Researchers measure…

This completed study from the University of Hong Kong looked at 110 cannabis users aged 16-60 to see how their thinking skills change over time and if genes play a role. Participants took memory and thinking tests and gave blood for genetic analysis. The goal is to understand lon…

This study tested a program where community health workers were trained to help people with opioid addiction get and stay in treatment, with support from their families. Over 1,600 adults who use drugs took part in communes across Vietnam. The goal was to see if this community-ba…

This study measured how much nicotine gets into the blood and how smokers feel after using heated tobacco products, regular cigarettes, or nicotine gum. Eighty adult smokers took part in a six-day clinic stay where they tried each product. The goal was to understand the appeal an…

This study measured the amount of xylazine—a dangerous animal sedative often mixed with opioids—in the blood and urine of 75 emergency room patients who had a non-fatal opioid overdose. The goal was to see how common xylazine is and how well test strips can detect it. The finding…

This completed Phase 1 study at UCLA looked at how smoking cannabis with different amounts of THC and CBD affects drug levels in oral fluid and blood, as well as thinking and feeling. Nineteen adults who use cannabis occasionally took part. The goal was to better understand how t…

This study looked at how smoking affects a brain chemical called glutamate in men versus women. Researchers scanned the brains of 58 smokers after not smoking overnight and after their first cigarette of the day. They also measured hormone levels in women to see if hormones influ…

This study looked at whether a program called MISSION-CJ can help homeless veterans who have both substance use and mental health problems stay out of trouble with the law. 134 veterans took part, and researchers tracked arrests, substance use, housing, and employment. The goal w…

This study looked at 385 adults diagnosed with their first lung or head & neck cancer to see how many continued using tobacco or alcohol over the next year. Researchers tracked smoking and drinking habits, as well as how long patients lived without the cancer getting worse. The g…

This study looked at pregnant women being treated for opioid use disorder with two different forms of buprenorphine: a monthly shot and a daily tablet. Researchers measured drug levels in the mother's blood and checked the baby's heart rate to see how each treatment affected both…

This study looked at 71 babies born to mothers who took either a monthly injection or a daily tablet of buprenorphine for opioid use disorder during pregnancy. Researchers measured the babies' thinking, language, and motor skills using a standard child development test. The goal …

This study explored whether how addicted a person is to nicotine affects their awareness of having gum disease. Researchers examined 350 smokers with gingivitis or periodontitis, measuring their nicotine dependence with a standard test and asking about their gum health. The goal …

This study looked at whether little cigars and cigarillos (LCCs) are addictive, especially when flavored like fruit, and if addiction differs between men and women. Researchers studied 65 young adults aged 18-34 who smoke both LCCs and cigarettes. They measured how much people wo…

This study looked at how negative emotions and stress influence alcohol use in 81 women veterans, including those with PTSD. Researchers measured cravings, heart rate, and drinking patterns, and also examined how these effects change across the menstrual cycle. The goal was to be…

This study looked at how the amount of sugar in cigarette tobacco affects how much people enjoy smoking and how addictive the cigarettes seem. Thirty adult smokers tested cigarettes with different sugar levels and answered questionnaires about their experience. The goal was to se…

This study tested a program called CRAFT-EP, which helps families support a relative with early psychosis and substance use (like alcohol or cannabis). The program was delivered entirely through video calls. Researchers measured family members' depression and anxiety to see if th…

This study measured a specific enzyme in the blood of 93 people to see if it is linked to psychotic symptoms in methamphetamine users. Participants included people with methamphetamine use disorder, those with methamphetamine-induced psychosis, and healthy volunteers. The goal wa…

This completed study surveyed 3,100 adults in Slovakia to find out how many people have mental disorders like depression, anxiety, PTSD, or addiction. Researchers used a standard interview tool to measure current and lifetime rates, and looked at who gets help and who doesn't. Th…

This completed study in Slovakia examined how psychological factors like resilience, stress, and positive thinking relate to the body's immune system. Researchers measured immune markers in blood and compared them to mental health questionnaires in 700 adults, including people in…

This study looked at whether gradually lowering opioid doses over time affects pain, quality of life, and mood in people with chronic non-cancer pain. 18 adults on stable opioid therapy were followed to compare slow tapering versus staying on their current dose. The goal was to s…

This study tested whether a set of strategies—including community teamwork, tech-based training, and peer support—could improve HIV testing and substance use care for people about to be released from jail. Researchers worked with 65 incarcerated individuals in one New York county…

This study tested a web-based toolkit called MOM CARE designed to help jail staff provide better care for pregnant people with opioid use disorder. The toolkit includes medical guidance and best practices from intake to release. Researchers worked with 22 jail staff members to se…

This study looked at whether people with alcohol dependence or a history of early life stress have more trouble learning to feel calm after a scary event. Researchers used brain scans, mild electric shocks, and genetic tests to understand these differences. The goal was to learn …

This completed study looked at 574 hospitalized adults with end-stage liver disease to see if alcoholic patients had the same chance of getting on the national liver transplant waiting list as non-alcoholic patients. The goal was to find out if non-medical reasons limit access fo…

This study measured harmful chemicals in the air after adults used either a heated tobacco product (ploom) or regular cigarettes in a sealed room. Researchers tracked over 20 pollutants like nicotine, formaldehyde, and benzene. The goal was to see how the two products differ in s…

This study tested whether sending e-mails to doctors could encourage them to use a state-run prescription monitoring program and reduce unsafe opioid prescribing. About 7,800 Minnesota physicians and physician assistants who were not using the program as required took part. The r…

This study looked at whether a questionnaire called the Behavioral Activation for Depression Scale (BADS) is a good tool for measuring depression-related behaviors in people with substance use disorders. Researchers analyzed answers from 289 adults receiving treatment for substan…

This completed study with 65 adult smokers and vapers tested how different rules and penalties affect whether people buy illegal tobacco products. Participants used a simulated store to see how promotion factors and mitigation strategies like fines changed their buying choices. T…

This study looked at whether a single dose of methylphenidate (Ritalin) changes how people with both ADHD and alcohol use disorder respond to alcohol-related cues. Thirty-one adults aged 18-25 completed brain scans, EEG, and behavioral tests after taking either the drug or a plac…

This study looked at ways to prevent tuberculosis (TB) in Malaysian prisoners, many of whom also had HIV, opioid addiction, or hepatitis. Researchers compared a standard 40-week TB prevention treatment with a shorter 12-week option. The goal was to see which approach worked bette…

This study looked at whether cannabis use affects sperm quality in infertile men. Researchers compared sperm samples from 71 men who used cannabis and those who did not. They measured sperm DNA health and other factors to see if cannabis might be linked to fertility problems.

This study looked at how a pill form of THC (dronabinol) affects sleep and thinking in 18 adults. Some participants used cannabis frequently (more than 3 times a week), while others rarely used it (less than 10 times ever). Researchers measured sleep stages, alertness, memory, an…

This study looked at whether adding a brain wave monitor (pEEG) to standard sedation checks helps reduce delirium and time on a breathing machine in ICU patients. Researchers followed 150 adults on ventilators who needed sedation. They compared those who got both the brain monito…

This study tested an 8-month program called 'Meaningful Activities and Recovery' (MA&R) for people with mental illness. The program helps people take part in activities that matter to them. 139 adults took part to see if the program improves activity engagement, recovery, and qua…

This pilot study tested whether a computer avatar that delivers a smoking cessation program, combined with help from a community health worker, could help people in Baltimore public housing quit smoking and get screened for lung cancer. Ten adults aged 50 or older who smoked took…

This study looked at how different marketing messages about tobacco-free nicotine pouches affect what people think about them. Over 5,000 participants in the US, including smokers and young non-users, answered survey questions after seeing ads. The goal was to understand how word…

This completed study at Yale University looked at how 66 adult smokers (ages 21-44) perceive sweet, cooling, and unflavored e-cigarette liquids. Participants tried each flavor and rated its appeal, sensory effects, and how much they wanted it compared to money. The goal was to se…

This study looked at how often thiamine (vitamin B1) deficiency occurs in hospitalized veterans who do not abuse alcohol. Thiamine deficiency can cause symptoms like fatigue, confusion, and weakness, and may be more common in veterans due to food insecurity and chronic illness. R…

This completed study tested different strategies to help emergency doctors start buprenorphine treatment for people with opioid use disorder. Researchers used a computer system to prompt nurses and doctors, and gave patients educational materials. The goal was to see which combin…