New hope for pregnant women battling opioid addiction: monthly shot vs daily pill

NCT ID NCT03918850

Completed Disease control Sponsor: T. John Winhusen, PhD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a once-monthly injection of buprenorphine works as well as daily pills to treat opioid use disorder in 140 pregnant women. The goal was to see if the monthly shot could reduce illicit opioid use during pregnancy and after birth. Results help doctors choose the best treatment for both mother and baby.

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Conditions

The condition(s) this trial relates to.

drug dependence neonatal abstinence syndrome opiate dependence pregnancy disorder substance abuse substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DRUG ABUSE DRUG ABUSE IN PREGNANCY DRUG ADDICTION NEONATAL ABSTINENCE SYNDROME NEONATAL OPIOID WITHDRAWAL SYNDROME OPIOID-RELATED DISORDERS PREGNANCY RELATED SUBSTANCE ABUSE

Contacts and locations

Locations

Addiction Recovery Services (ARS), Swedish Medical Center

Seattle, Washington, 98107, United States
Boston Medical Center

Boston, Massachusetts, 02118, United States
CODA, Inc.

Portland, Oregon, 97214, United States
Gateway Community Services

Jacksonville, Florida, 32204, United States
Marshall Health MARC Program

Huntington, West Virginia, 25701, United States
Massachusetts General Hospital HOPE Clinic

Boston, Massachusetts, 02114, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Pregnancy Recovery Center at Magee-Womens Hospital of UPMC

Pittsburgh, Pennsylvania, 15213, United States
University of Cincinnati Health Perinatal Addictions Program

Cincinnati, Ohio, 45229, United States
University of New Mexico Milagro Clinic

Albuquerque, New Mexico, 87106, United States
University of Utah SUPeRAD Clinic

Salt Lake City, Utah, 84108, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States

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