New combo treatment aims to help veterans quit smoking and manage PTSD

NCT ID NCT03978442

Completed Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study tested a treatment called CPT-SMART that combines PTSD therapy, smoking cessation counseling, medication, and financial incentives to help veterans quit smoking. 120 veteran smokers with PTSD were randomly assigned to either the full program or a control group. The goal was to see if this combined approach leads to higher quit rates and better engagement in treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bupropion (Zyban)
What this could lead to: If successful, this approach could provide an effective way to help veterans with PTSD quit smoking, reducing smoking-related illness and death.
What could go wrong: This is a completed Phase 4 trial with 120 participants, so results are available but may not apply to all smokers with PTSD. The intervention is complex and may not be widely adopted.

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Conditions

The condition(s) this trial relates to.

nicotine dependence post-traumatic stress disorder Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMOKING STRESS DISORDERS, POST-TRAUMATIC

Contacts and locations

Locations

Durham VA Medical Center, Durham, NC

Durham, North Carolina, 27705-3875, United States

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