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Could a probiotic supplement help reverse fatty liver?

NCT ID NCT06352697

Completed Disease control Sponsor: Bogomolets National Medical University Source: ClinicalTrials.gov ↗

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study tests whether a daily capsule containing fragments of a probiotic bacterium (L. rhamnosus) can reduce liver fat and improve blood markers in adults with metabolic dysfunction-associated steatotic liver disease (MASLD). Participants take either the supplement or a placebo for three months, with follow-up for another three months. The goal is to see if this postbiotic approach safely lowers liver fat and inflammation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Probiotic lysate (postbiotic and metabiotic) from L. rhamnosus
What this could lead to
If effective, this supplement could offer a simple, non-drug way to reduce liver fat and inflammation in people with fatty liver disease.
What could go wrong
This is a small, early-stage trial with only 50 participants, so results may not apply broadly. The supplement may not significantly improve liver health, and long-term effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alcoholic fatty liver disease fatty liver disease metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATIC STEATOSIS METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE STEATOTIC LIVER DISEASE

Contacts and locations

Locations

  • Bogomolets National Medical University

    Kyiv, 01601, Ukraine

  • Center for Innovative Medical Technologies of the National Academy of Sciences of Ukraine

    Kyiv, 02000, Ukraine

  • Danylo Halytsky Lviv National Medical University

    Lviv, 79010, Ukraine

  • Kyiv City Clinical Endocrinology Center

    Kyiv, 01601, Ukraine

  • Taras Shevchenko National University of Kyiv

    Kyiv, 01601, Ukraine

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