Could a single stem cell infusion help both alcoholism and depression?

NCT ID NCT03265808

Completed Disease control Sponsor: Ihsan M Salloum, MD, MPH Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tested whether a one-time infusion of donor stem cells is safe for people with both alcohol use disorder and major depression. Thirty-one participants received either the stem cells or a placebo. The main goal was to check for serious side effects, like suicidal thoughts or hospital stays. Researchers also looked at changes in inflammation levels in the blood.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: donor stem cells (allogeneic human mesenchymal stem cells)
What this could lead to: If it works, this could point toward a new treatment option for people struggling with both alcohol use disorder and depression.
What could go wrong: This is a very early, small trial (31 people) focused mainly on safety, not effectiveness. The stem cells are from donors, so the body might reject them, and long-term benefits are uncertain.

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Conditions

The condition(s) this trial relates to.

alcohol abuse major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALCOHOL USE DISORDER MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

University of Texas Rio Grande Valley School of Medicine

Harlingen, Texas, 78550, United States

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