Monthly shot vs. daily pills: new hope for opioid treatment in rural america?

NCT ID NCT06023459

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tested whether a once-monthly injection (XR-BUP) works as well as daily pills (SL-BUP) for treating opioid use disorder in rural settings. 140 adults with moderate to severe opioid use disorder took part. The goal was to see if the injection is practical and acceptable in rural clinics, and how it compares in reducing opioid use.

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Conditions

The condition(s) this trial relates to.

Narcotic-Related Disorders opiate dependence substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • AppleGate Recovery El Dorado

    El Dorado, Arkansas, 71730, United States

  • Gibson Area Hospital and Health Services - Gibson Recovery Optimizing Wellness

    Gibson City, Illinois, 60936, United States

  • New Beginnings Recovery Clinic & Behavioral Health Center

    New Martinsville, West Virginia, 26155, United States

  • Oregon Health & Science University Primary Care Clinic, Scappoose

    Scappoose, Oregon, 97056, United States

  • Penobscot Community Health Care Inc. - Seaport Community Health Center

    Belfast, Maine, 04915, United States

  • Providence Northeast Washington Medical Group

    Colville, Washington, 99114, United States

  • Southern Humboldt Community Healthcare District - Jerold Phelps Community Hospital

    Garberville, California, 95542, United States