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Personalized web therapy may curb teen substance use and mental health struggles

NCT ID NCT06306287

Disease control Sponsor: Oregon Research Institute Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 27, 2026 · Last updated Sep 01, 2026 · Updated 3 times

Summary

This trial tests a web-based program called ePACE, which gives teens with mild to moderate substance use and mental health issues personalized choices about content and engagement. It compares ePACE to a fixed, non-tailored program (eFACE) and to a waitlist group. Researchers will measure changes in substance use and emotional and behavioral problems over 3 and 6 months. The goal is to see if a flexible, youth-driven approach works better than a one-size-fits-all intervention.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A personalized web-based behavioral intervention (ePACE) that combines motivational enhancement and cognitive behavior therapy, compared to a fixed, non-tailored web intervention (eFACE) and a waitlist control.
What this could lead to
If ePACE works, it could offer an accessible, engaging early intervention that helps teens reduce substance use and manage co-occurring mental health issues, potentially preventing more serious problems later.
What could go wrong
This is a small, early-stage trial with 66 participants, so results may not apply broadly. The intervention relies on self-report and web engagement, which may not suit all teens, and the personalized approach might not outperform the fixed version.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

132 people

The number who actually took part.

Started

Feb 2024

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Adolescent Inclusion Criteria: * 12-17 years * live at home with at least one parent or parent figure * reporting mild/moderate substance use * reporting mental health issues * sufficient English language skills for assessments and intervention Adolescent Exclusion Criteria: * a sibling has already participated in the study * evidence of psychotic or organic state * high problem severity indicating possible need for higher level of care Parent Inclusion Criteria: • sufficient English language skills for assessments and intervention Parent Exclusion Criteria: • another parent or parent figure is already participating in the study

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Conditions

The condition(s) this trial relates to.

mental disorder substance abuse substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mental health issue Substance use

Contacts and locations

Locations

  • Oregon Research Institute

    Albuquerque, New Mexico, 87109, United States

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