Can a natural compound help kick the vaping habit?

NCT ID NCT05431387

Completed Disease control Sponsor: Achieve Life Sciences Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a pill called cytisinicline, made from a plant compound, to see if it helps adults stop using nicotine e-cigarettes. 160 daily vapers took either the drug or a placebo for 12 weeks, along with brief counseling. The main goal was to see if more people could quit vaping for at least 4 weeks by the end of treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cytisinicline (also known as cytisine) – a plant-based tablet to reduce nicotine cravings
What this could lead to: If successful, this could provide a new medication option to help people quit vaping, similar to how it is used for smoking cessation.
What could go wrong: This is a small Phase 2 trial with only 160 participants, so results may not apply to everyone. The drug may not prove more effective than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

nicotine dependence Vaping

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

E-CIG USE VAPING

Contacts and locations

Locations

Alliance for Multispecialty Research, LLC

Lexington, Kentucky, 40509, United States
Alliance for Multispecialty Research, LLC

Knoxville, Tennessee, 37920, United States
Coastal Carolina Research Center

North Charleston, South Carolina, 29405, United States
Massachusetts General Hospital - Clinical Genetic Research Facility

Boston, Massachusetts, 02114, United States
Rochester Clinical Research, Inc

Rochester, New York, 14609, United States

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