Can a puff of pot throw your heart out of rhythm?
NCT ID NCT06021613
First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time
Summary
This trial investigates whether smoking or vaping cannabis increases the frequency of premature atrial and ventricular contractions — early or extra heartbeats that can feel like skipped beats. Over 14 days, regular cannabis users will be randomly assigned to consume or avoid cannabis on different days while wearing a heart monitor, glucose monitor, and fitness tracker. The goal is to see if cannabis use is linked to changes in heart rhythm, glucose levels, step counts, and sleep.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- inhaled cannabis (smoked or vaped)
- What this could lead to
- If cannabis is linked to more abnormal heartbeats, it could inform safer use guidelines for millions of Americans.
- What could go wrong
- This is a small, short-term observational trial in regular users, not a definitive test of long-term heart risks. Results may not apply to occasional users or other forms of cannabis.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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108 people
The number who actually took part.
- Started
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Jan 2024
- Finished
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May 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
21 years and older
- Sex
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Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Are age 21 or older 2. Have a smartphone 3. Are able to use the Eureka mobile application and Mosio text messaging software 4. Have inhaled cannabis in the past month and on at least four different days in the same week in the past year 5. Are willing to consume and abstain from inhaled cannabis for no more than two consecutive days as instructed over the 14-day trial period 6. Are able to participate in a location where cannabis use would not break any established laws under any jurisdiction 7. Are able to self supply cannabis throughout the study duration Exclusion Criteria: 1. Currently pregnant or trying to get pregnant 2. Have a medical reason to avoid cannabis 3. Are unwilling to avoid all forms of cannabis consumption on days instructed to abstain from cannabis 4. Are currently taking anti-arrhythmic medications 5. Have a history of atrial fibrillation or heart failure 6. Have congenital heart disease 7. Have an implantable cardioverter-defibrillator or pacemaker 8. Have had a previous cardiac ablation procedure 9. Are currently taking insulin 10. Are unable to read or sign to provide informed consent
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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UCSF Medical Center at Mission Bay
San Francisco, California, 94158, United States
-
UCSF Medical Center at Parnassus
San Francisco, California, 94143, United States
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