Opioid study reveals how painkillers affect mood before surgery
NCT ID NCT05639712
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed study in Norway looked at how opioids like morphine, oxycodone, and fentanyl affect patients' mood and pain right before surgery. Over 1,000 healthy adults scheduled for day surgery answered questions about anxiety, relaxation, and pain after receiving a small dose of opioid or a placebo. The study also tracked how much pain medication patients needed after surgery and what factors predicted long-term opioid use or persistent pain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Morphine, oxycodone, fentanyl, and placebo (saline)
What this could lead to
If successful, this could help doctors understand how opioids affect mood and pain, potentially leading to better pain management after surgery.
What could go wrong
This is a completed Phase 4 study focused on observation and short-term effects, not a treatment trial. Results may not apply to all patient groups.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Harald Lenz
Oslo, Oslo, Norway