Opioid study reveals how painkillers affect mood before surgery

NCT ID NCT05639712

Completed Knowledge-focused Sponsor: Oslo University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study in Norway looked at how opioids like morphine, oxycodone, and fentanyl affect patients' mood and pain right before surgery. Over 1,000 healthy adults scheduled for day surgery answered questions about anxiety, relaxation, and pain after receiving a small dose of opioid or a placebo. The study also tracked how much pain medication patients needed after surgery and what factors predicted long-term opioid use or persistent pain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Morphine, oxycodone, fentanyl, and placebo (saline)
What this could lead to: If successful, this could help doctors understand how opioids affect mood and pain, potentially leading to better pain management after surgery.
What could go wrong: This is a completed Phase 4 study focused on observation and short-term effects, not a treatment trial. Results may not apply to all patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Affective Symptoms opioid abuse

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AFFECTIVE SYMPTOMS OPIOID USE

Contacts and locations

Locations

Harald Lenz

Oslo, Oslo, Norway

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