Could a simple antibiotic boost survival in severe alcoholic hepatitis?

NCT ID NCT02281929

Completed Disease control Sponsor: University Hospital, Lille Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding an antibiotic (amoxicillin-clavulanic acid) to the usual steroid treatment could improve survival in people with severe alcoholic hepatitis. About 300 adults at high risk of death within two months took part. The goal was to see if the antibiotic, given before any infection appeared, would help more patients be alive at two months compared to steroids alone.

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Conditions

The condition(s) this trial relates to.

alcoholic hepatitis alcoholic liver disease hepatorenal syndrome Infections

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALCOHOLIC HEPATITIS ALCOHOLIC LIVER DISEASE

Contacts and locations

Locations

CHU

Angers, France
CHU

Rouen, France
CHU

Toulouse, France
CHU Grenoble

Grenoble, France
CHU Montpellier

Montpellier, France
CHU Nantes

Nantes, France
CHU Nice

Nice, France
CHU Poitiers

Poitiers, France
CHU Pontchaillou

Rennes, France
CHU d'Amiens

Amiens, France
CHU de Besançon

Besançon, France
CHU de Caen

Caen, France
Centre Hospitalier

Valenciennes, 59300, France
Centre hospitalier

Dunkirk, France
Hôpital BEaujon (AP-HP)

Clichy, France
Hôpital Claude Huriez, CHU

Lille, France
Hôpital Jean Verdier (AH-HP)

Bondy, 93143, France
Hôpital La Pitié (AP-HP)

Paris, France
Hôpital Paul Brousse (AH-HP)

Villejuif, 94000, France
Hôpital Saint Antoine (AP-HP)

Paris, 75012, France

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