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E-Cig flavor study targets smokers with opioid addiction

NCT ID NCT07594717

Knowledge-focused Sponsor: Prisma Health-Upstate Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Aug 04, 2026 · Updated 3 times

Summary

This study looks at how different e-cigarette flavors appeal to adults who have opioid use disorder and are on buprenorphine treatment. Participants will smell and rate 11 flavors for sweetness, coolness, strength, and how likely they'd use them again. The goal is to find flavors that might help these individuals switch from smoking to potentially less harmful e-cigarettes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
E-cigarette flavors (sweet-cooling, sweet non-cooling, tobacco)
What this could lead to
If successful, this study could identify e-cigarette flavors that make switching from smoking more appealing for people with opioid use disorder, potentially reducing harm from cigarettes.
What could go wrong
This is a small, early-stage observational study (70 participants) that only measures flavor preferences, not actual health outcomes. Results may not apply to all e-cigarette users or lead to any real-world changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

70 people

The number who actually took part.

Started

Nov 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

E-cigarette users with opioid use disorder receiving burpenorphine

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 21 years or older. * Current e-cigarette users who report e-cigarette use on ≥20 of the past 30 days. * Former daily cigarette smokers who currently smoke on ≤19 days per month and no more than 5 cigarettes per day. * Diagnosed with opioid use disorder (OUD). * Currently receiving buprenorphine treatment for OUD. Exclusion Criteria: \-

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Conditions

The condition(s) this trial relates to.

nicotine dependence opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nicotine use disoder Opioid-use disorder

Contacts and locations

Locations

  • Prisma Health Recovery Clinic-Greenville

    Greenville, South Carolina, 29605, United States

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