Cannabis study reveals how THC and CBD impact impairment and drug tests

NCT ID NCT05037487

Completed Knowledge-focused Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed Phase 1 study at UCLA looked at how smoking cannabis with different amounts of THC and CBD affects drug levels in oral fluid and blood, as well as thinking and feeling. Nineteen adults who use cannabis occasionally took part. The goal was to better understand how to detect recent cannabis use and measure its effects on the brain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Smoked cannabis with varying amounts of THC and CBD
What this could lead to: If successful, this research could improve roadside drug testing and help understand how different cannabis components affect impairment.
What could go wrong: This is a small, early-phase study with only 19 participants, so results may not apply to everyone. It focuses on measurement, not treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cannabis dependence poisoning substance abuse substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DRUG ABUSE IMPAIRMENT INTOXICATION BY DRUG

Contacts and locations

Locations

University of California, Los Angeles

Los Angeles, California, 90095, United States

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