Substance-related disorder

This trial tests whether an AI-driven texting tool, combined with support from peer recovery coaches, can help Black and Latinx people who use opioids start buprenorphine treatment in primary care. Participants are enrolled from emergency departments and receive text messages wit…

This study tests whether a daily kava drink can help active smokers who don't plan to quit reduce their smoking and lower their risk of lung cancer. Twenty adult smokers will take kava daily for several months. Researchers will check how well participants stick with the regimen, …

This trial tests whether valproate, a medication used for epilepsy, can help prevent or ease alcohol withdrawal symptoms in heavy drinkers admitted to trauma care. Participants receive standard treatment with lorazepam (a benzodiazepine) as needed, and some also get valproate. Th…

This study tests whether combining a gentle brain stimulation technique called tDCS with computer-based cognitive training can help people with stimulant or alcohol use disorders stay abstinent. Participants, who have already been abstinent for at least three weeks, will receive …

This study investigates how effectively two opioid antidotes—naloxone (given as a nasal spray or injection) and nalmefene (given as an injection)—can reverse dangerous breathing problems caused by strong opioids like fentanyl. The trial includes both healthy volunteers and people…

This trial tests whether a weekly IV antibiotic called oritavancin, given alongside medication for opioid use disorder, can help people finish treatment for serious infections like bloodstream or bone infections without needing to stay in a nursing facility. The study enrolls adu…

This study tests whether adding peer-based counseling to standard HIV and opioid treatment helps people who inject drugs stay on their medications and achieve viral suppression. Participants receive either enhanced usual care or extra support from a peer counselor. The goal is to…

This phase 2 trial tested whether cannabidiol (CBD), a non-psychoactive compound from cannabis, could help people with alcohol use disorder reduce their drinking. The study also looked at whether CBD could protect the brain and liver from alcohol's harmful effects. Only 10 people…

This study tested a drug called INT-787 in 67 people with severe alcohol-associated hepatitis, a serious liver condition. The trial was a phase 2a proof-of-concept study, but it was terminated early. Researchers were looking at safety, how well the drug works, and how the body pr…

This study tested whether a type of brain stimulation called intermittent theta burst stimulation (iTBS) could help people with alcohol use disorder reduce cravings and risky behavior during inpatient treatment. Only 2 people were enrolled before the trial was stopped early. The …

This phase 2 study tested a drug called TMP-301 in 110 adults with alcohol use disorder to see if it is safe and helps reduce drinking. Participants took TMP-301 or a placebo daily for 14 weeks. The trial was terminated early, so we don't have clear results on whether the drug wo…

This study tested a drug called acamprosate in adults with alcohol dependence who were part of a DUI court program. The goal was to see if the medication could help them stay sober and reduce cravings. Only 4 people enrolled before the study was stopped, so results are very limit…

This study looked at whether different medications for opioid use disorder (methadone, buprenorphine/naloxone, or naltrexone) could reduce immune system inflammation in people with HIV. Researchers measured changes in blood markers of immune activation over 24 weeks. The trial wa…

This study aimed to see if giving smokers access to different e-cigarette flavors (menthol, non-tobacco, or tobacco) helps them stop smoking regular cigarettes. Over 600 adult smokers were assigned to different flavor groups and tracked for 13 weeks. However, the trial was termin…

This study tested a mobile app that uses rewards to encourage people with opioid use disorder to start and stick with medication-assisted treatment after an emergency room visit. 41 adults from two hospitals were given access to the app for 12 weeks. The goal was to see if the ap…

This small, early-phase study tested whether the heart medication digoxin could reduce inflammation in people with severe alcohol-associated hepatitis. 23 participants were randomly assigned to receive intravenous digoxin or no digoxin for up to 28 days. The trial was terminated …

This study tested a special program called ADAPT for families who adopted children from foster care. The program includes sessions on trust, behavior management, and dealing with loss. Researchers wanted to see if it could improve children's mental health and prevent family disru…

This study tested educational videos for Hispanic/Latinx families with teens aged 15-17 to prevent opioid misuse and overdose. The program focused on safe storage, opioid knowledge, and changing attitudes. Only 6 families took part before the study ended early.

This study tested a program to help HIV-negative transgender women and men who have sex with men who also have a substance use disorder stick with PrEP, a daily pill or shot that prevents HIV. Participants received counseling and text support, with extra help for those who strugg…

Researchers are testing whether a 12-week exercise program can improve thinking skills, physical fitness, and quality of life for adults in opioid substitution therapy. Participants are randomly assigned to start exercise right away or after a 12-week wait. The study measures cha…

Researchers at the University of Florida are testing whether computerized cognitive training can help people with alcohol use disorder improve their memory, self-control, and thinking skills during inpatient treatment. Participants complete up to 12 sessions of adaptive brain-tra…

Transgender and gender diverse adults smoke at higher rates than the general population, and stigma, discrimination, anxiety, and depression may make quitting harder. Researchers at Massachusetts General Hospital are adapting an existing smoking cessation program called QUIT, whi…

This study tests whether a wearable device that sends tiny electrical pulses to the ear — a method called transcutaneous auricular neurostimulation (tAN) — can help people going through alcohol withdrawal. The device targets the vagus and trigeminal nerves, which may influence wi…

This early-stage trial tests whether a daily tablet called BI 1356225 can improve impulse control in people with opioid use disorder who are already taking buprenorphine. About 60 participants will be randomly assigned to receive either the study drug or a placebo for 8 days. Res…

This study tested whether a combination of non-opioid medicines (ketamine, ketorolac, and acetaminophen) can control pain after robotic prostatectomy as well as standard opioid painkillers. Men aged 40-75 with prostate cancer were randomly assigned to receive either opioids or th…

This early study tested a new drug called TRV734 in 5 adults with opioid-use disorder who were already on methadone. The goal was to see if TRV734 could relieve withdrawal symptoms with fewer side effects than a standard opioid like oxycodone. Participants stayed in a residential…

This study tested a small device worn on the ear that uses mild electrical pulses to help control pain after a liver transplant. The goal was to see if it could reduce the need for strong painkillers like opioids. The study was stopped early and included 27 adults waiting for a l…

This study tested whether psilocybin, the active ingredient in magic mushrooms, is safe and feasible for people with methamphetamine use disorder. Only 5 participants were enrolled, and the trial was terminated early, so the results are very limited. The goal was to see if psiloc…

This study looked at whether buprenorphine can effectively treat chronic pain in people who are dependent on opioid painkillers, while also reducing withdrawal symptoms and improving quality of life. It involved 4 adults with opioid dependence and chronic pain. The approach was t…

This study tested a new method for starting buprenorphine (a medication for opioid use disorder) in hospitalized adults who also have chronic pain. Instead of requiring patients to stop all other opioids and go through withdrawal first, the new method starts with very low doses o…

This study tested whether a specially designed video game could reduce alcohol-related problems like hangovers, blackouts, and risky sex in LGBTQ+ teens aged 14-18. The game was meant to teach safer drinking habits. The study was stopped early and only 28 people took part, so res…

This study tested a mindfulness-based mobile app designed specifically for young Black men (ages 18-29) to help them handle stress from racism and reduce alcohol or marijuana use. Participants used a self-guided app, some with real-time feedback, and reported their daily stress a…

This study tested whether giving methadone to ICU patients on breathing machines could help them get off the ventilator faster. Patients who needed strong painkillers were given either methadone or a placebo. The trial was stopped early and only included 9 people, so no firm conc…

This study tested a device called Bridge to see if it could reduce symptoms of opioid withdrawal. Researchers compared it to a fake device in 13 adults with opioid use disorder. The study was stopped early, so results are limited.

This study tested whether pramipexole (Mirapex), a drug for restless legs syndrome, could also reduce symptoms of opioid withdrawal in people with opioid use disorder. The trial planned to enroll 75 adults but was terminated early. Researchers measured changes in restless legs se…

This study looks at whether imagining positive future events (Episodic Future Thinking) and using low-intensity focused ultrasound on the brain can help people with both chronic pain and alcohol use disorder. Ten adults will try these interventions and report changes in pain, cra…

This study looks at how men and women with cannabis use disorder react differently to THC, the main psychoactive ingredient in cannabis. Researchers will give 40 adults either a THC pill or a placebo and use brain scans to measure changes in reward-related brain activity. The goa…

This observational study at Yale University is recruiting 200 people who are already taking part in another trial where they may receive a serotonergic psychedelic (like psilocybin or LSD) or a placebo. Researchers want to understand how these substances change the brain's inform…

This study aimed to see if a short test called BEARNI could detect alcohol-related cognitive impairments (like memory and thinking problems) in people with alcoholic cirrhosis. The researchers planned to enroll patients with cirrhosis, but the study was stopped early after only o…

This study looked at how being exposed to alcohol before birth might affect adults' ability to read emotions and make decisions. Researchers planned to compare adults with prenatal alcohol exposure to those without, using computer tasks. The study was terminated early and only en…

This study tested whether a non-invasive brain stimulation technique called deep rTMS could change brain activity and reduce smoking in people with schizophrenia. Researchers used brain scans to measure changes in brain connections and smoking behavior. The study was small and en…

This study aimed to understand how withdrawal symptoms and drug-related cues influence decision-making in people with opioid use disorder. Participants completed choice tasks to see if they preferred high-probability rewards. The study was terminated early and only enrolled 2 par…

This study examined whether ride-sharing services like Uber and Lyft are linked to fewer alcohol- and drug-related car accidents and sexual assaults. Researchers collected data from trauma registries, transportation departments, and crisis centers in the Dallas area. The study wa…

This study tested whether a mobile app (eIntervention) could help adults with moderate to high-risk drug or alcohol use reduce their substance use and get into treatment. Participants were primary care patients who screened positive for substance use. The app was added to standar…

This study tested a care coordination and motivational interviewing program for women who recently had a preterm birth. The goal was to see if the program was feasible and acceptable to participants. Only 13 women enrolled before the study was terminated, so the findings are very…

This study aimed to see if taking the experimental drug AEF0117 with food changes how much gets into the bloodstream. It involved 22 healthy adults aged 18 to 55. The trial was terminated early, so results are limited.

This study tracked 239 adults in France taking baclofen for alcohol use disorder. Researchers called participants monthly for a year to see how many stopped the drug due to side effects. The goal was to better understand which side effects are caused by baclofen versus other fact…

This study tested a smartphone app designed to help people with opioid addiction by sending helpful messages at just the right moment. Nine adults who used heroin or other opioids carried a phone that beeped four times a day to ask about their mood and activities, then showed a m…