Experimental pill for alcoholism hits roadblock: trial terminated

NCT ID NCT06648655

Terminated Disease control Sponsor: Tempero Bio, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This phase 2 study tested a drug called TMP-301 in 110 adults with alcohol use disorder to see if it is safe and helps reduce drinking. Participants took TMP-301 or a placebo daily for 14 weeks. The trial was terminated early, so we don't have clear results on whether the drug works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TMP-301
What this could lead to: If it worked, TMP-301 could help people with alcohol use disorder drink less or stay sober longer.
What could go wrong: This trial was terminated early, so results are limited. It was a small phase 2 study, and it's unclear if TMP-301 is effective or safe in the long run.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alcohol abuse substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALCOHOL USE DISORDER (AUD)

Contacts and locations

Locations

Baylor College of Medicine

Houston, Texas, 77030, United States
CNS Healthcare

Orlando, Florida, 32801, United States
CNS Healthcare- Jacksonville South

Jacksonville, Florida, 32256, United States
CenExcel iResearch

Decatur, Georgia, 30030, United States
CenExcel iResearch

Savannah, Georgia, 31405, United States
DelRicht Research - Murphy Clinic

Mandeville, Louisiana, 70448, United States
Headlands Research

Scottsdale, Arizona, 85260, United States
IMA Clinical Research

Albuquerque, New Mexico, 87109, United States
Medical University of South Carolina, Institute of Psychiatry

Charleston, South Carolina, 29425, United States
Neurobehavioral Research, Inc.

Cedarhurst, New York, 11516, United States
Research Centers of America, LLC

Hollywood, Florida, 33024, United States
Segal Trials - West Broward Outpatient Site

Lauderhill, Florida, 33311, United States
University of Virginia: Center for Leading Edge Addiction Research

Charlottesville, Virginia, 22903, United States
Yale School of Medicine

New Haven, Connecticut, 06511, United States

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