Flavored vapes tested as smoking cessation aid – but study ends early

NCT ID NCT07172438

Terminated Disease control Sponsor: RAI Services Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aimed to see if giving smokers access to different e-cigarette flavors (menthol, non-tobacco, or tobacco) helps them stop smoking regular cigarettes. Over 600 adult smokers were assigned to different flavor groups and tracked for 13 weeks. However, the trial was terminated early, so the full results are not available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: electronic nicotine delivery system (ENDS) with various e-liquid flavors
What this could lead to: If successful, this could show that offering a choice of flavors in e-cigarettes helps more smokers switch away from combustible cigarettes.
What could go wrong: The study was terminated early, so we may not get clear answers. Also, e-cigarettes carry their own health risks and may not help everyone quit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

nicotine dependence Smoking Tobacco Smoking Tobacco Use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMOKING TOBACCO

Contacts and locations

Locations

C&C-Arlington

Arlington, Texas, 76015, United States
C&C-Fort Smith

Fort Smith, Arkansas, 72908, United States
C&C-Humble

Humble, Texas, 77338, United States
C&C-Lombard

Lombard, Illinois, 60148, United States
C&C-Mesquite

Mesquite, Texas, 75150, United States
C&C-Philadelphia

Philadelphia, Pennsylvania, 19154, United States
C&C-Plantation

Plantation, Florida, 33388, United States
C&C-Richmond Heights

St Louis, Missouri, 63117, United States
C&C-San Antonio

San Antonio, Texas, 78216, United States
C&C-San Antonio

San Antonio, Texas, 78224, United States
C&C-Sebring

Sebring, Florida, 33870, United States
C&C-Tallahassee

Tallahassee, Florida, 32301, United States
C&C-Tampa

Clearwater, Florida, 33761, United States
C&C-Troy

Troy, Michigan, 48083, United States
CRG Test America-Grapevine

Grapevine, Texas, 76051, United States
CRG Test America-Ormond Beach

Ormond Beach, Florida, 32174, United States
CRG Test America-Pembroke Pines

Miami, Florida, 33026, United States
CRG Test America-Phoenix

Chandler, Arizona, 85226, United States
CRG Test America-St. Peters

City of Saint Peters, Missouri, 63376, United States
CRG Test America-Tampa

Tampa, Florida, 33609, United States
Research America Orlando

Altamonte Springs, Florida, 32701, United States
Sago Dallas

Dallas, Texas, 75254, United States
Sago Houston

Houston, Texas, 77027, United States
Sago Orlando

Maitland, Florida, 32751, United States
Sago Philadelphia

Philadelphia, Pennsylvania, 19103, United States
Sago St. Louis

St Louis, Missouri, 63131, United States
Southern Solutions Knoxville

Knoxville, Tennessee, 37922, United States

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