Substance-related disorder

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with severe alcohol use disorder reduce heavy drinking. Thirty-six adults who recently completed detox will receive either a high or low dose of psilocybin du…

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This study tests whether a natural molecule called oleoylethanolamide (OEA) can reduce inflammation, improve thinking, and lower alcohol use in young adults aged 18–25 with alcohol use disorder. Participants will take OEA or a placebo daily for 6 weeks and provide blood, saliva, …

This trial tests whether simple reminders—sent to patients' phones and to their care teams—can increase the use of alcohol screening and brief counseling (SBIRT) during cancer care. About 315 adults with cancer across four clinics will take part, with some clinics using the remin…

This trial explores whether a single dose of psilocybin, combined with motivational support therapy, can help people with HIV who have moderate-to-severe methamphetamine use disorder reduce or stop their meth use. Participants will be randomly assigned to receive either a higher …

This trial tests whether a counseling method called motivational interviewing, based on the Transtheoretical Model, can help nursing students who smoke to change their smoking habits and quit. Participants will receive two to six face-to-face sessions tailored to their readiness …

This study compares how adult smokers experience IQOS heated tobacco products versus their usual cigarettes. Participants use both products and rate them on appeal, taste, harshness, and satisfaction. Researchers also measure puffing behavior and nicotine withdrawal symptoms. The…

This trial tests whether switching to cigarettes with very low nicotine content can reduce how much people smoke and their nicotine exposure. Adult daily smokers in South Korea will be randomly assigned to either very low nicotine or normal nicotine cigarettes for 12 weeks. Resea…

This trial tests whether a text message-based program called Text2Quit-Kenya can help current tobacco users who visit the emergency department at Kenyatta National Hospital in Kenya quit smoking. Participants receive automated, interactive texts timed around their quit date to tr…

This trial tests a program called ROOTS that places substance use counselors and peer recovery specialists directly in rural schools. The goal is to see if this approach helps teens who are referred or seek help on their own to engage in treatment and reduce their substance use. …

This study looks at whether a program called EMPOWER, led by trained peer supporters, can help homeless veterans with substance use or mental health issues stay engaged in care and avoid repeated hospital stays or emergency visits. About 278 veterans in permanent supportive housi…

This trial tests whether an individually tailored form of behavioral activation therapy can help people who use drugs after release from incarceration. Participants receive 12 therapy sessions over 8 weeks, integrated into a reentry primary care program with peer support. The stu…

This trial tests whether adding a relational health enhanced parenting support (RHEP) program to standard family-focused peer recovery services helps parents with substance use disorders. The study compares outcomes like parenting satisfaction, treatment retention, and substance …

This study tests whether the drug varenicline (Chantix) can help veterans who smoke at least 5 cigarettes a day but aren't ready to quit. Participants will either take varenicline or use nicotine lozenges to reduce smoking over 12 weeks. The goal is to see if this approach leads …

This pilot study will test whether giving a monthly extended-release buprenorphine injection (BRIXADI) from a mobile pharmacy clinic is acceptable and practical for people with opioid use disorder. About 60 participants will receive the shot for 6 months, and researchers will tra…

This trial tests whether a brain-training technique called neurofeedback can help people with crack cocaine use disorder improve their self-control and reduce cravings. Participants in residential treatment will receive either standard care alone or standard care plus up to 30 se…

This study in Nairobi, Kenya, will test whether a drug called cytisine, combined with counseling, can help 300 people with HIV quit smoking and reduce heavy drinking. Participants will receive either cytisine or a placebo, plus either intensive counseling or standard advice. The …

This study will test whether a smartphone app can help people with HIV in Laos quit smoking. About 1,200 smokers from eight HIV clinics will be split into two groups: one gets the app with tailored messages and videos, the other gets printed self-help materials. The goal is to se…

This study tests a program that provides overdose education and naloxone (a drug that reverses opioid overdoses) to homeless veterans at risk. The program is being rolled out at VA sites that serve veterans in supportive housing. Researchers will measure how well sites adopt the …

This trial tests whether pregnenolone, a natural hormone, can help adults with both alcohol use disorder and major depression. Participants take either pregnenolone or a placebo for 12 weeks, while researchers track drinking, cravings, and mood. Brain scans will also look at how …

This trial tests whether integrating tobacco cessation tools into electronic health records can increase the number of smokers who receive a prescription for nicotine replacement therapy (NRT) like patches or gum. Researchers will compare a new workflow at one primary care clinic…

This study tests whether a 6-month program delivered through the Telegram messaging app can help people stop smoking after a heart attack. 142 adult smokers who use Telegram will either get the chatbot support or standard advice. The goal is to see if more people quit with the ch…

This study tests whether a comprehensive telehealth platform called RecoveryPad helps adults with moderate to severe opioid use disorder start and stay in medication treatment. Researchers will enroll 470 participants and track attendance at treatment appointments within 30 and 9…

This trial tests whether a digital medical device called Quitoxil®, which offers cognitive behavioral therapy and connects users with trained patient experts, can improve smoking cessation rates when added to standard nicotine replacement therapy. About 600 adults who smoke at le…

This study tests a smoking cessation program designed for veterans who have chronic pain. Participants receive counseling over the phone plus nightly automated calls to report their smoking and pain levels. The goal is to see if this approach helps more veterans quit smoking comp…

This study tests a program called Abstinence Reinforcement Therapy (ART+) to help veterans who are homeless quit smoking. The program combines telehealth counseling, nicotine replacement therapy, and financial rewards for staying smoke-free. Researchers will compare ART+ to stand…

This study looks at whether adding a recovery coach and an online sober community can help people who have had a liver transplant stay away from alcohol. About 40 adults who received a liver transplant in the last 5 years and have a history of alcohol use disorder will take part.…

This study tests a harm reduction approach for people who use anabolic-androgenic steroids (AAS) without a prescription. Participants will receive four counseling sessions to help them reduce their steroid use and improve their health. The trial will measure changes in steroid us…

This trial tests whether a six-week body-focused mindfulness program can help people with alcohol use disorder feel more connected to their bodies, manage emotions better, and reduce alcohol cravings. Participants in inpatient treatment will either take part in mindfulness sessio…

This study tests whether a counseling program tailored to a person's readiness to change can help gym-goers reduce or stop using anabolic-androgenic steroids (AAS). Participants are randomly assigned to receive either the tailored counseling or standard health education. The goal…

This study tests whether a program called CourtConnect, where peer recovery specialists meet with people in courthouses, can increase substance use disorder treatment and reduce overdose and incarceration. The program provides information, referrals, and up to three months of fol…

This trial tests whether the sleep medication daridorexant can help people with alcohol use disorder and insomnia drink less. Participants take either daridorexant or a placebo nightly for 12 weeks, along with brief counseling. The study tracks alcohol use through self-reports an…

This pilot study investigates whether adding Dialectical Behavior Therapy (DBT)-informed principles to standard short-term inpatient substance abuse treatment helps patients better manage emotions and reduce symptoms. About 70 adults in a 12-week program will either receive usual…

This Phase 2 trial at Johns Hopkins will test whether combining semaglutide (a GLP-1 drug used for diabetes) with naltrexone (a medication for alcohol dependence) is safe and helps reduce alcohol use. About 45 adults with alcohol use disorder will take the combination or a placeb…

This study tests a new eight-session group therapy program for adults hospitalized with substance use disorders. The program combines motivational interviewing, acceptance and commitment therapy, and behavioral activation to help participants manage cravings and develop alternati…

This early-phase trial tests a digital program called CONNECT, designed to help women who have survived sex trafficking access care for HIV, substance use, and mental health. Delivered through a street medicine team that serves unhoused women, the program pairs participants with …

Coal miners in Central Appalachia use tobacco at very high rates and face serious lung diseases like cancer and black lung. This study tests a new approach: lawyers handling black-lung compensation cases identify miners who use tobacco and connect them to community pharmacists. T…

This trial investigates whether cognitive cycling—a series of structured mental exercises—can help prevent relapse in adults with alcohol use disorder after they complete alcohol withdrawal. Participants are randomly assigned to receive either 12 cognitive cycling sessions over f…

This study tests whether tirzepatide, a drug approved for weight management, can help people who are obese and have a moderate to severe stimulant use disorder (like methamphetamine or cocaine). Participants receive weekly injections for 20 weeks, along with counseling and brain …

This early-stage study at Yale is testing whether a combination of two medications (naltrexone and bupropion) plus cognitive-behavioral therapy can help people who are considering bariatric surgery lose weight and stop smoking. Twenty participants will receive the treatment for f…

This study tests whether a gentle electrical stimulation of a nerve in the ear (called taVNS) can help people who are dependent on the drug tiletamine. Thirty participants will receive either real or sham stimulation over five days. Researchers will measure changes in cravings, m…

This study tests a program that combines medication (Naltrexone + Bupropion) with behavior therapy to help adults lose weight and quit smoking before bariatric surgery. Researchers will compare this approach to standard care in 64 participants aged 18-65 who smoke and have obesit…

This study tests a text- and web-based tool called FamilyCHESS, designed to help people with moderate to severe opioid use disorder begin and stay on medication. The tool also involves a concerned family member or friend who provides support. Researchers will compare outcomes lik…

This pilot study tests a behavioral program called CBITS-RTM, adapted for teens in juvenile detention. The program combines group and individual therapy to address post-traumatic stress and includes a module on racial trauma. Researchers want to see if it reduces PTSD symptoms an…

This pilot study tests whether offering rewards for taking smoking cessation medication and completing counseling calls helps people quit smoking. Participants receive varenicline and referrals to a state quitline, with some also getting incentives tracked by a smart pill dispens…

This trial investigates whether pregnenolone, a natural neurosteroid, can help adults who struggle with both cannabis use disorder and major depression. The study involves a small group of 20 participants aged 18 to 50 who use cannabis frequently and want to cut back. Researchers…

This study tests whether nimodipine, a blood pressure medication, can reduce alcohol consumption and craving in adults with Alcohol Use Disorder who are heavy drinkers. Participants receive nimodipine or a placebo over 18 hours, then take part in a controlled drinking session whe…

This 12-week study tests whether a weekly injection of tirzepatide, a drug used for diabetes, combined with motivational therapy can help adults with moderate to severe cannabis use disorder. Fifteen participants will receive escalating doses of tirzepatide along with counseling.…

This study tests a program called MISSION-CJ that helps people leaving jail who have both mental health and substance use disorders. The program connects them with peer support and community services to stay in treatment and avoid relapse. Researchers will track how well particip…

This study tests whether peer support specialists—people who have been through liver transplant for alcohol-related disease themselves—can help others in the same situation stay sober and attend medical appointments. About 95 participants will meet regularly with a peer supporter…

This trial tests a culturally adapted program called SBIRT (Screening, Brief Intervention, and Referral to Treatment) for trauma patients who drink alcohol. Emergency department staff in Cameroon will screen patients for risky drinking, offer a short motivational counseling sessi…

This study tests whether a smart chatbot can help adults quit smoking as effectively as human support. About 1,000 smokers in Hong Kong will use a WhatsApp chatbot for 12 weeks, receiving personalized advice and encouragement. The goal is to see if the chatbot can boost quit rate…

This study tests whether peer recovery coaches—people who have personally overcome opioid addiction—can help others with opioid use disorder quit smoking. About 60 adults on medication for opioid use disorder who smoke daily will receive either coaching from a peer coach or stand…

This phase 2 trial tests whether a high-protein diet (30% protein, 40% carbs, 30% fat) can reduce liver fat and improve liver function in 72 adults with alcoholic fatty liver disease. Participants will be randomly assigned to either the high-protein diet or a standard diet for 6 …

This study will test whether cannabis can reduce the severity of opioid withdrawal and make opioid use safer. One hundred adults with opioid use disorder will live in a hospital for about six weeks. Researchers will give them cannabis and a small dose of opioids to see how their …

This phase 2 trial will test whether semaglutide, the drug in Ozempic, can help people with methamphetamine use disorder cut down their use. Forty adults who use methamphetamine at least 14 days per month will receive weekly injections for 12 weeks. The study will check if the tr…

This study tests whether offering buprenorphine treatment directly at syringe service programs (SSPs) helps more people start and stay on medication for opioid use disorder compared to referring them elsewhere. About 512 adults who use SSPs and have moderate to severe opioid use …

This study tests whether a new four-session group program, called the First Step Program, can be delivered in hospital settings and help people with substance use disorders. The program combines motivational interviewing, acceptance and commitment therapy, and group support to bo…

This trial tests whether an AI chatbot called MICA, combined with weekly text reminders, can help emergency department patients reduce risky alcohol use. About 750 adults who report heavy drinking will be randomly assigned to use MICA or receive usual care. The study tracks how m…

This pilot study tests a program called Kisoboka Amaka for men living with HIV who drink heavily and have pregnant partners. The program combines counseling, financial training, and mobile savings to help men drink less and take their HIV medication consistently. Researchers will…

This study tests a combination of telehealth, peer support, and medication (buprenorphine) to help people with opioid use disorder stay in treatment after leaving the emergency room. The goal is to reduce repeat overdoses and prevent deaths. About 160 adults who have had an opioi…

This study will test a Spanish-language program called Healthy Choices for 45 young adults (ages 18-29) living with HIV in the Dominican Republic who also struggle with alcohol use and stigma. The program is designed to help them better manage their health and reduce the impact o…

This study is developing and testing a smartphone app called METS4Vets, designed to help veterans with substance use disorders as they move from residential treatment back into everyday life. The app provides motivational and skills-building support. Researchers are enrolling 30 …

This study tests whether cannabis-based treatments can safely reduce seizures in people aged 2 to 55 with drug-resistant epilepsy. Participants will receive either a pure CBD extract, a CBD-rich herbal cannabis extract, or a placebo. The goal is to see if these treatments lower m…

This early-phase trial will test the safety and blood levels of an investigational drug called MCAM in 24 healthy adults. Participants will receive a single dose of MCAM or a placebo and be monitored for 8 days. The goal is to find the highest safe dose for future studies on opio…

This pilot study will develop and test a telehealth program designed to help marginalized patients access and stay in treatment for opioid use disorder. Researchers will enroll 60 people—half already in treatment and half not yet in treatment—and provide them with a user-friendly…

This study tests whether giving hospitalized heavy drinkers a liver stiffness scan and personalized alcohol counseling can reduce future emergency hospital visits. 500 adults at risk of alcohol-related liver disease will be randomly assigned to get this extra support or usual car…

This pilot study tests whether repetitive transcranial magnetic stimulation (rTMS) can strengthen a brain circuit linked to staying away from cannabis. Fifty treatment-seeking youth aged 15–21 with cannabis use disorder will receive either real or sham rTMS. Researchers will chec…

This study tests whether adding two FDA-approved cannabinoids—dronabinol (synthetic THC) and epidiolex (CBD)—to standard buprenorphine treatment can help people with opioid use disorder stay in treatment and reduce opioid use. The trial will enroll 40 adults who recently started …

This study looks at whether adding a mobile app to a nurse-led counseling program helps men with alcohol use disorder stay sober longer. About 74 men aged 18-59 who own an Android phone will take part. The goal is to see if the app reduces relapse rates over three months compared…

This trial investigates whether Cobenfy, a medication typically used for schizophrenia, can reduce the rewarding effects of cocaine in people with cocaine use disorder. Over an 11-day inpatient stay, participants receive either Cobenfy or a placebo twice daily, then take part in …

This study tests two behavioral interventions—Behavioral Activation (finding enjoyable activities) and Attendance Reinforcement (vouchers for showing up)—to help people with opioid use disorder stay on buprenorphine treatment for at least 6 months. Researchers will enroll 240 adu…

This study tests a very brief smoking cessation intervention called 3A-OR in family health centers across Turkey. About 2,400 smokers aged 15 and older will be randomly assigned to receive the intervention or usual care. The intervention involves asking about tobacco use, assessi…

This study tests whether completing methadone clinic intake during a hospital stay helps people with opioid use disorder stay connected to treatment after leaving. Researchers will compare usual care (a referral at discharge) to a program where hospital staff complete key steps l…

This pilot study will test a clinic that treats both heart failure and methamphetamine use disorder at the same time. Fifty adults with heart failure and active meth use will receive counseling, incentives for staying clean, and optional addiction medications, plus standard heart…

This study tests a digital pill system that tracks when people with alcohol-related liver disease take their medication (acamprosate) and provides personalized support to help them stay on track. The system includes a sensor in the pill, a wearable patch, and a smartphone app wit…

This phase II trial tests whether a palm-derived form of vitamin E (tocotrienol) can improve liver health in adults with alcoholic fatty liver disease. 26 participants will take either the supplement or a placebo for six months, with regular blood tests and liver scans to track c…

This study tests a new care model for veterans with opioid use disorder that combines infectious disease screening and treatment with their usual medication-assisted therapy in a single appointment. The goal is to make it easier for veterans to get tested and treated for infectio…

This trial tests a coordinated care program called CCAP for men with alcohol problems in primary care centers in Goa, India. The program includes mobile messages for mild cases, counseling for moderate cases, and home detoxification for severe cases. Over 1,000 participants will …

This study tests a 'rapid restart' approach for people with opioid use disorder who have missed 4-8 doses of methadone. Instead of slowly increasing the dose again, participants may return to their previous stable dose right away. The goal is to see if this method is acceptable a…

This study tests whether daridorexant, a drug used for insomnia, can reduce alcohol cravings and drinking while improving sleep in people with alcohol use disorder and sleep problems. About 150 adults will receive either daridorexant or a placebo for several weeks. The goal is to…

This study tests a program called CROSSROADS for adults who recently survived an opioid or stimulant overdose. It combines standard paramedic care with free legal help for issues like housing or benefits. Researchers want to see if this reduces drug use and contact with the crimi…

This study tests whether giving buprenorphine (a medication for opioid addiction) through telemedicine works as well as in-person care. Fifty adults with opioid use disorder will be randomly assigned to either remote or in-person treatment. The main goal is to see how long people…

This early-stage study tests a new oral medication called VK4-116 in 48 healthy adults to see if it is safe and how the body processes it. The drug is being developed as a potential treatment for opioid dependence and opioid use disorder. Participants will receive a single dose o…

This study tests whether a nurse navigator program can reduce hospital readmissions in 300 patients who are having hip or knee replacement and also have conditions like heart failure, COPD, or kidney problems. The program provides education and connects patients with their primar…

This study will test whether e-cigarettes or a natural supplement called cytisine can help people who smoke at least 5 cigarettes a day and haven't been able to quit with standard treatments like nicotine patches or counseling. Over 4 years, 6,000 participants will be randomly as…

This study tests a non-invasive brain stimulation technique called transcranial temporal interference stimulation (tTIS) aimed at the amygdala, a brain region linked to cravings. Researchers will enroll 60 adults with alcohol use disorder to see if tTIS can reduce alcohol craving…

This study tests two methods for starting buprenorphine treatment in adults with opioid use disorder who use fentanyl. Participants will be randomly assigned to either a low-dose start or a direct injection approach. The goal is to see which method helps people stay in treatment …

This study tests whether giving financial rewards based on a blood test can help people with alcohol-related liver disease stop or reduce drinking. The blood test detects alcohol use over the past month. 90 adults will be randomly assigned to either a rewards group that gets esca…

This study tests a medicine called tirzepatide to see if it can help people with moderate to severe cannabis use disorder use less cannabis or stop altogether. One hundred adults aged 18 to 70 will receive either the drug or a placebo, and researchers will track their cannabis us…

This study tests whether repeated sessions of a gentle brain stimulation technique called tDCS can help people with alcohol use disorder drink less. Over 12 weeks, 312 participants will receive either real or sham tDCS in 5-day clusters each month. The goal is to see if this appr…

This Phase 3 trial tests a naltrexone implant placed under the skin to help people with moderate to severe alcohol use disorder drink less. About 240 adults will receive either the implant or a placebo, plus counseling. Researchers will track heavy drinking days over 24 weeks to …

This study tests whether a low-dose anti-inflammatory drug called colchicine can help people who have had a brain hemorrhage (a type of stroke) recover better and avoid future heart attacks or strokes. About 1,125 adults with signs of artery disease will take either colchicine or…

This study will test an app called JomCare that sends personalized support to men who have sex with men when they are most likely to engage in chemsex (using drugs before or during sex). The goal is to reduce risky behaviors and prevent new HIV infections. About 482 HIV-negative …

This study tests a biodegradable implant called OLANI that slowly releases naltrexone to block the effects of opioids for weeks. Researchers will enroll 250 adults with opioid use disorder who have already completed withdrawal. Participants will receive up to four implants over a…

This study tests whether semaglutide (a GLP-1 drug used for diabetes and weight loss) can help people with obesity and fatty liver disease reduce or stop drinking alcohol. 64 participants will receive either semaglutide injections plus lifestyle counseling, or counseling alone. T…

This study tests whether a 12-week program of supervised exercise, Mediterranean diet education, and stress management workshops can improve health in 120 overweight or obese adults. Participants will wear a smart bracelet to track activity and sleep. Researchers will measure cha…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce liver fat in people with alcohol-related fatty liver disease (MetALD). 105 participants will receive either personalized rTMS, standard rTMS, or a sham (placebo) treatment over 20 sessions.…

This study tests whether combining ketamine-assisted psychotherapy with mindfulness training (called KetaMORE) helps people with opioid use disorder who are already on medication. 88 participants will be randomly assigned to receive either KetaMORE or ketamine with a support grou…

This study will create and test a smartphone app designed to help teenagers in Indonesia stop smoking. About 110 teens aged 13-15 who smoke will be split into two groups: one using the new app and the other using paper materials. Researchers will check if the app helps them stay …

This study tests whether eating fiber-rich snacks (with inulin and pectin) for 28 days, alongside standard care, can improve alcohol withdrawal in adults aged 19-65 with alcohol use disorder. The goal is to reduce gut permeability and support recovery. Participants will provide b…

This study tests whether offering gift cards can help people leaving jail stick with their medication for opioid use disorder. Participants earn up to $600 for attending appointments and counseling over three months after release. The goal is to reduce the high risk of overdose d…

This study tests whether a weekly injection of tirzepatide (a diabetes drug) plus cognitive-behavioral therapy can help adults with alcohol use disorder and overweight or obesity reduce heavy drinking days. 46 participants will receive either the drug or a placebo shot for 8 week…

This pilot study tests whether tirzepatide, a drug used for diabetes, can reduce cravings in people with severe cannabis use disorder. Six adults will receive either tirzepatide or a placebo injection and then be exposed to cannabis-related cues to measure craving intensity. The …

This study tests whether offering rewards (contingency management) can help people who use methamphetamine reduce their use after a traumatic injury. Twenty adults admitted to the hospital with a positive meth test will receive urine tests and rewards for negative results, starti…

This study tests whether offering medication for opioid use disorder (buprenorphine) in community settings—like churches or social service centers—via telemedicine, plus one-on-one coaching, helps people stay in treatment longer than standard clinic care. About 400 participants w…

This study tests a talking therapy called the Cannabis Clinic for Psychosis (CCP) to help people with first-episode psychosis reduce or stop cannabis use. The therapy includes motivational interviewing and cognitive behavioral therapy in weekly sessions over 12 weeks. Researchers…

This small pilot study will test whether adding ketamine to cognitive behavioral therapy (CBT) is safe and feasible for people with both alcohol use disorder and major depression. Twenty participants will receive three ketamine injections over six weeks along with CBT sessions. T…

This pilot study will test whether a high-intensity brain stimulation device can help people with alcohol use disorder reduce their cravings and drinking. Eighteen adults will receive 20 sessions of stimulation over 10 days. Researchers will measure changes in cravings, drinking …

This study aims to create personalized treatment plans for people with opioid use disorder by using machine learning to find the best sequence of medications and behavioral therapy. Researchers will test these plans in a small pilot study with 75 adults to see if they are feasibl…

This pilot study tests whether a peer-led program called Yuva Sath can help young people (ages 18-29) who inject drugs stay engaged in substance use treatment and HIV prevention. The program includes six one-on-one sessions with a peer counselor and weekly text check-ins. Researc…

This study will bring medication for addiction and cognitive behavioral therapy to homeless veterans living in VA supportive housing. The goal is to help them stay housed and reduce substance use. About 8,000 veterans across multiple VA sites will take part.

This study tests a behavioral program called contingency management for people with opioid use disorder. Participants in an inpatient unit receive small rewards when they provide drug-free urine samples. The goal is to see if this approach helps them stay abstinent during their t…

This study tests whether a monthly injection of buprenorphine (a medication for opioid dependence) works well and is affordable in low- and middle-income countries. About 760 adults who inject drugs and have opioid dependence will receive the injection and be followed for 48 week…

This study will test a new, non-invasive device that measures blood flow and oxygen levels in the brains of newborn babies. Researchers will compare babies who were exposed to opioids before birth with those who were not. The goal is to see if the device can detect signs of opioi…

This study tests if adding a safe dye to a drink can prove that urine samples are real and not tampered with. About 114 adults with substance use disorder will drink Gatorade with or without the dye, then provide a urine sample 15 minutes later. Researchers will check for the dye…

This study looks at whether measuring a protein called TREM-1 in liver tissue can help doctors better predict how patients with severe alcoholic hepatitis will do. Researchers will compare TREM-1 levels in 300 people—half with alcoholic hepatitis and half with other liver disease…

This study tests whether sending fentanyl test strips by mail and providing online education can reduce opioid overdoses. Researchers will enroll 100 adults who use opioids or stimulants and live in states where test strips are legal. The goal is to find the most effective and lo…

This trial tests whether higher doses of nicotine replacement therapy (NRT) can help adults who use both cigarettes and e-cigarettes quit both products. Participants are randomly assigned to receive either standard-dose NRT, augmented-dose NRT, or no NRT, with all groups getting …

This trial tests whether a brief psychological intervention—combining education, mindfulness, and acceptance-based strategies—can help people who have had a musculoskeletal injury reduce their opioid use and avoid developing chronic pain. The study enrolls adults admitted to the …

This trial tests whether giving students accurate information about their peers' actual behavior can reduce heavy drinking and risky sexual activity. About 1,350 adolescents in three Ugandan schools will complete surveys and receive personalized feedback comparing their own estim…

This study tests a mobile health app called mSYNC designed to help prevent HIV in people who use drugs and visit the emergency department. The app provides counseling and support for risk behaviors, mental health, and access to care. Researchers want to see if the app is acceptab…

This trial tests a digital app that coaches parents of 5th and 6th graders on how to discourage underage alcohol use. Many parents allow sips, which raises the risk of serious problems later. The study involves 4,000 parent-child pairs and measures teen drinking over time.

This study tests a six-session behavioral program for stimulant-using men at high risk for HIV. The program focuses on positive thinking, mindfulness, and building supportive networks to help participants start taking PrEP (a daily pill that prevents HIV) and reduce stimulant use…

This study tests whether a single session of Acceptance and Commitment Therapy (ACT) can help internally displaced adults manage stress and prevent substance use. Researchers will enroll 144 people who have been displaced by conflict and have used at least one substance (other th…

This study tests LaunchPad, an online program designed to help high school seniors avoid drug and alcohol problems as they leave school. Researchers will randomly assign 5,000 students to different lessons and measure changes in their attitudes, confidence, and intentions around …

This study aims to help outpatient clinics provide HIV prevention medication (PrEP) and sterile injection equipment to people who inject drugs. Researchers will work with clinics to develop and test a bundle of strategies, including patient education, provider training, and syste…

This study looks at whether long-acting HIV prevention shots and opioid use disorder medications can help people in prison who are about to be released. Researchers will enroll 450 adults at participating prisons and follow them to see if they stick with treatment and avoid HIV, …

This study tests whether a brief digital program can help teenagers ages 12-17 who vape reduce their e-cigarette use and lower their risk of starting to smoke cigarettes. About 150 teens in California will take online surveys over 12 weeks, and some will also do a virtual intervi…

This study tests Project LYNX, a program that helps young adults (ages 18-29) who have recently been involved with the criminal legal system find and connect to substance use treatment and HIV-prevention services. The program pairs each participant with a trained peer navigator a…

This study tests a mobile app called PA-LINKS designed to help women who have recently been in jail or prison access HIV prevention medicine (PrEP) and treatment for opioid use disorder. About 74 women will use the app and work with a navigator to connect to these services. The g…

This study tests a mindfulness program called MINDS-UP to prevent substance use in children aged 10 to 14. About 45 kids will either take mindfulness classes plus a sports-based prevention program, or just the sports program alone. Researchers will check if the program is easy to…

This study tests a clinical decision support tool that helps primary care providers safely taper opioid doses in patients. The tool provides guidelines and reminders to reduce withdrawal and overdose risks. About 200,000 patients will be involved, and researchers will compare out…

This study tests whether giving financial rewards to pregnant women who smoke—and to their smoking partners—helps them quit. About 180 pregnant women and their partners will be split into three groups: one where only the woman gets money for quitting, one where both get money, an…

This study tests a smartphone game called MedSMA℞T Mobile, designed to help parents and their teenage children learn how to use, store, and dispose of opioids safely. About 244 families will play the game for 30 minutes and complete surveys over 9 months. The goal is to see if th…

This study tests a virtual reality (VR) program for 8th graders to prevent them from starting to use e-cigarettes. About 1,250 students from schools in Connecticut and Massachusetts will play a VR game that teaches skills to handle emotions and resist vaping. The goal is to see i…

This study tests whether a social network approach can encourage people who inject drugs to start HIV prevention medication (PrEP) and addiction treatment (MOUD). About 398 participants will be assigned to either the LINKED intervention or a control group. The goal is to see if p…

This study tests whether internet-based programs can prevent alcohol use disorders in people who are not currently seeking help. About 3,500 adults with risky drinking habits will be randomly assigned to receive online brief advice, unguided online therapy, or guided online thera…

This study looks at ways to improve care for teens and young adults who have experienced sexual assault. The goal is to offer same-day HIV prevention medicine and substance use support during their emergency room visit. Researchers will work with young people to design and test t…

This study tests two smartphone tools to help HIV-negative men who have sex with men take their daily HIV prevention pill (PrEP) regularly and reduce methamphetamine use. One hundred men with mild to moderate meth use disorder will use the apps for 6 months. Researchers will chec…

This trial tests a school-based program that combines classroom lessons with online modules to reduce the risk of vaping and prescription drug misuse in upper elementary students (ages 7-11). About 3,000 students from 30 schools will either receive the program or continue with st…

This study tests if a phone-based therapy called Acceptance and Commitment Therapy (ACT) can help young adults aged 18-35 who drink heavily to quit or reduce alcohol use. Participants will receive weekly phone sessions for 6 weeks and track their drinking. The study compares ACT …

This study tests whether a brain-training technique called neurofeedback can help people with opioid use disorder who are on methadone feel more pleasure and recall positive memories. Participants learn to control their brain activity using real-time fMRI scans, a method that has…

This study tests whether inhaling high-THC cannabis can safely reduce PTSD symptoms in 320 veterans. Participants will either receive active cannabis or a placebo with almost no THC. The goal is to see if cannabis helps with PTSD severity and daily functioning, providing real-wor…

This study tests a brief psychological program designed to help people who have been hospitalized with a musculoskeletal injury and prescribed opioids. The program includes education about long-term opioid use and mindfulness-based strategies, delivered through a computer session…

This early-stage trial will give a single 10 mg dose of psilocybin to 70 adults recovering from trauma surgery who also have opioid use disorder. Researchers want to see if it's safe and practical to give psilocybin in the hospital, and how it affects pain, mood, and opioid use o…

This study tests whether a smartphone app with AI can help adolescents aged 14-20 quit e-cigarettes. Participants use the app to set goals, track progress, and get real-time support during cravings. Researchers compare an immediate-use group with a delayed-start group to see if t…

This study will test a new multilingual chatbot called LIFT-UP designed to help people living in poverty quit smoking. Researchers will interview 22 adults who smoke at least 3 cigarettes daily and are motivated to quit. The goal is to see if the chatbot is easy to use and helpfu…

This trial tests whether Snoezelen therapy—a calming, multisensory experience using lights, sounds, and textures—can improve health in adults with schizophrenia (including those needing institutional care) and women with alcohol dependence. Participants will attend 30-minute sess…

This trial tests whether Narrative Enhancement and Cognitive Therapy (NECT), a 12-session group program, can help adults with severe mental health disorders — including substance use disorders — overcome self-stigma and promote personal recovery. About 106 participants receiving …

This pilot trial tests whether a brief, culturally adapted support message sent to a smartphone during moments of high stress can reduce the urge to smoke, vape, or eat in response to stress. About 115 gender and sexual minority adults in Dhaka will receive up to five check-ins p…

This pilot study tests a short brain training program called EEG neurofeedback in adults with alcohol use disorder. Over about one week, participants complete three sessions where scalp sensors record brain activity and provide real-time feedback to help them lower alpha brain wa…

This study tests whether a compound from cannabis called THCV can help people who smoke daily to resist cigarettes and smoke less. 32 smokers will receive either THCV or a placebo and then take a test measuring how long they can delay smoking and how many cigarettes they smoke. T…

This study tests a smartphone app called Senyo Health for people with bipolar disorder who also struggle with alcohol or drug use. The app offers therapy, rewards for healthy behaviors, and weekly check-ins with a care manager. The goal is to see if the app is easy to use and hel…

This study tests whether personalized feedback, based on real-time data from smartphones and wearable devices, can help Veterans with PTSD who use cannabis. The feedback aims to show how PTSD symptoms, cannabis use, and daily behaviors like sleep and activity are connected. The g…

This study tests a smartphone app called KIOS designed to help people recovering from opioid addiction manage their health. Researchers will track how well participants stay in treatment over one year and who benefits most from the app. About 134 adults who recently started bupre…

This pilot study tests a culturally adapted empowerment self-defense program for Indigenous women (including American Indian, Alaska Native, and Two Spirit individuals) who have experienced sexual violence and currently have moderate to severe depression or PTSD. The program teac…

This study tests a mindfulness program designed to help sexual assault survivors reduce alcohol misuse and tobacco use. Researchers will enroll 120 college students aged 18-24 who have experienced sexual violence and drank alcohol recently. Participants will take online surveys a…

This study tests a new 8-session group program designed to help people with substance use disorder better understand and regulate their emotions. About 20 adults receiving inpatient care at two hospitals in Korea will take part. The program combines motivational interviewing and …

This study tests whether cannabidiol (CBD), a compound from cannabis, can reduce alcohol withdrawal symptoms and cravings in people with moderate-to-severe alcohol use disorder. 105 adults will stay in a hospital for 5 days, receive either CBD or a placebo alongside standard care…

This study tests an online platform called PURSUIT that teaches coping skills to Michigan youth aged 8-18 and their caregivers. The program provides cognitive-behavioral techniques for managing pain, stress, and mood, with extra substance use prevention content for teens 12 and o…

This study tests whether a ketone supplement drink can reduce cravings and withdrawal symptoms in adults with opioid use disorder who are undergoing detox in a treatment center. Fifty participants will receive either the ketone drink or a placebo three times daily for seven days.…

This study tests whether brief, 1-2 minute videos featuring personal stories from other parents can reduce stigma and improve help-seeking among parents of children aged 6-18 with depression, ADHD, or substance use problems. Researchers will recruit 1,600 parents online and rando…

This study tests a two-session Zoom-based therapy designed to change beliefs about mental health treatment in Deaf adults who are not currently in care. Researchers will compare those who receive the therapy to a waitlist group to see if it increases treatment-seeking and reduces…

This pilot study tests a program to help construction workers in Hong Kong quit smoking. Participants will get nicotine gum, a week of nicotine replacement therapy samples, and 12 weeks of support from a chatbot via WhatsApp. The study will see if this combined approach is practi…

This study looks at whether a nutritional ketone supplement can alter how the brain uses energy and reduce alcohol consumption in people with alcohol use disorder. Sixty adults who drink heavily but are not seeking treatment will receive either the supplement or a placebo, then u…

This study tests whether taking cannabidiol (CBD) every night for four weeks can improve sleep quality and reduce alcohol cravings and use. Fifty-eight adults with poor sleep and hazardous drinking will take either CBD or a placebo. Participants will wear activity monitors, compl…

This pilot study tests a new program for young adults (25 or under) in Hong Kong who recently quit smoking. The program combines personalized counseling with an AI chatbot that sends supportive messages for 30 days. Researchers want to see if this approach is practical and accept…

This study looks at whether emergency medical services (EMS) can safely start buprenorphine treatment for people with opioid use disorder right at the scene of an emergency. Researchers will first test how practical and acceptable this approach is, then track whether patients sta…

This study will compare two pain medications, buprenorphine and oxycodone, in about 282 adults with injuries to at least two body areas. The goal is to see which provides better pain control with fewer risks. Participants will receive one of the two drugs as part of a standard pa…

This study tests whether an intelligent chatbot can help people quit smoking by joining their private online support groups. 120 adult smokers who are ready to quit within 10 days will be split into two groups: one with a chatbot that responds when no human does, and one with a s…

This study tests a smoking cessation program delivered via telemedicine and wearable devices. About 102 adult smokers will either get the program with remote monitoring or standard in-person support. The goal is to see if the tech-based approach helps more people quit and stay sm…

This study looks at whether a 6-week program that combines problem-solving therapy with small rewards can help new mothers feel less depressed and drink less alcohol. About 30 mothers who gave birth in the last year will take part. Half will get the program, and the other half wi…

This study tests whether brief mindfulness and identity-affirming exercises can improve well-being and reduce mental health symptoms in LGBTQ youth aged 16-26 who are currently or recently unhoused. Two hundred participants will be randomly assigned to either the mindfulness prog…

This study explores whether listening to music can help young adults (ages 18-35) manage stress during their first year of recovery from alcohol use disorder. Researchers will use a smartphone app and a wearable device to detect stress in real time and suggest calming music. The …

This study tests a smoking cessation program that combines a smartphone app with support from a psychologist. 429 adult smokers who want to quit will be placed into one of three groups: eight sessions with a psychologist plus the app, four sessions plus the app, or the app alone.…

This study tests whether a behavioral method called Emotional Brain Training (EBT) can help people in recovery from addiction manage stress, anxiety, and cravings. About 54 adults receiving standard addiction treatment will either continue their usual care or also attend weekly E…

This study tests whether hypnosis and self-exercises can help people with moderate to severe alcohol addiction control their drinking. About 98 outpatients will be split into two groups to compare the hypnosis-based approach with standard care. The main goal is to see how quickly…

This study tests whether listening to short, guided mindfulness audio recordings before and after surgery for a broken arm or leg can help reduce pain, anxiety, and the need for opioid painkillers. Fifty adults will be randomly assigned to either the mindfulness group or a contro…

This study tests whether equine-assisted therapy (working with horses) can improve mental health and reduce cravings in people recovering from addiction. Twenty-two adults who have completed detox will be randomly assigned to either receive 22 sessions of equine therapy over 24 w…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with psychotherapy is safe and can reduce depression and substance use in veterans and first responders who haven't responded to standard treatments. Fifty participants will r…

This study aims to help Native Hawaiian adults quit smoking by testing nicotine gum, group counseling, or both. About 75 participants from public housing sites on O'ahu will be assigned to one of three groups. Researchers will check which method works best for quitting and is mos…

This study tests dexmedetomidine, a sedative that doesn't slow breathing, in 246 premature babies on ventilators. The goal is to see if it reduces the need for opioids, shortens time on the breathing machine, and improves long-term brain development. Babies will receive the drug …

This early study will test whether nimodipine, a drug usually used for blood pressure, can reduce alcohol drinking and cravings in heavy drinkers. Five adults with Alcohol Use Disorder will stay overnight at a hospital, take nimodipine, and then have the option to drink alcohol o…

This study tests a new tool called SIM-AiR that helps teens (ages 12-19) with alcohol use disorder visually map their social identities and networks. The goal is to support lasting recovery by addressing social risk and protective factors. Researchers will ask teens and their cli…

This study tests a new way to help people going through alcohol withdrawal feel less anxious. It combines hypnosis with aromatherapy, using a calming scent to trigger the relaxation learned during hypnosis. About 80 adults in a hospital addiction unit will either get this combine…

This study tests whether daily motivational text messages can help people in rural Mississippi quit smoking or smokeless tobacco. Researchers will recruit 150 tobacco users who want to quit and have tried before. Half will get encouraging texts, the other half non-specific messag…

This pilot study tests whether adding music therapy to nicotine replacement therapy (patches and gum) helps healthcare professionals reduce smoking cravings more than nicotine therapy alone. 80 participants will be split into two groups and followed for 3 months. The study also l…

This study is testing a short behavioral treatment for women veterans who drink too much. The treatment involves 4 to 6 sessions with a behavioral health provider in a primary care clinic. Researchers want to see if it is practical, acceptable, and helps reduce alcohol use and im…

This study tests a 10-week cognitive remediation program for people with alcohol use disorder who are recently sober. The program includes group and individual brain exercises to improve thinking skills and self-confidence. Researchers will measure changes in general self-efficac…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy is safe and helpful for people who have both major depression and alcohol use disorder. Thirty adults will receive either psilocybin or a placebo, along with therapy sessions. The…

This early-stage study tests a brief couples therapy for 80 Veterans with PTSD and alcohol use disorder. Veterans receive individual treatment while attending 3-4 sessions with their romantic partner. The goal is to see if involving loved ones improves treatment satisfaction and …

This Phase 3 trial will test a web-based program called IMPACT for 250 veterans who have both opioid use disorder and chronic pain. The program includes 9 online modules and weekly feedback from a coach, all done from home. The goal is to see if it reduces how much pain interfere…

This study tests a nerve block given during minimally invasive colorectal surgery to see if it reduces pain and the need for opioids. Researchers will track 400 adults having left-sided colon or rectal surgery. The goal is to improve recovery and reduce side effects like nausea.

This study tests whether daridorexant, a recently FDA-approved sleep medication, can improve sleep quality and daytime alertness in smokers who struggle with insomnia during quit attempts. About 44 adult smokers who smoke at least 10 cigarettes daily will take the drug or a place…

This study will test a psychoeducation program based on cognitive behavioral therapy (CBT) for 44 adults diagnosed with substance use disorder. The program aims to reduce feelings of social exclusion and hopelessness, and improve participants' ability to cope with relapse. Resear…

This study compares face-to-face dialectical behavior therapy (DBT), online DBT, and usual treatment for people with addiction and emotional regulation difficulties. 120 adults will participate, learning skills to better manage emotions and reduce impulsivity. The goal is to see …

This study tests whether the PsyPills app can help emerging adults (ages 18-29) better manage their emotions and reduce risky behaviors like substance use, self-harm, or aggression. The app provides short, on-the-spot exercises to challenge unhelpful thoughts during moments of di…

This study tests a cannabis plant extract called NTI164, which has very low THC (the compound that causes a high), in 40 females aged 4-25 with Rett syndrome, a rare genetic condition causing severe physical and mental challenges. Participants will receive either NTI164 or a plac…

This study tests whether a full-spectrum cannabis plant extract called NTI164 can help reduce core autism symptoms (like social challenges and repetitive behaviors) in children and young adults aged 6 to 25. About 98 participants will receive either NTI164 or a placebo for 16 wee…

This pilot study will test a new type of talk therapy called ACT-SHARE for veterans who have both PTSD and alcohol problems and are struggling with conflict in their romantic relationships. The therapy aims to help veterans manage difficult thoughts and feelings and take actions …

This study tests whether a high-CBD cannabis extract is safe and helps relieve symptoms in people with moderate to severe restless legs syndrome (RLS). About 60 adults aged 18-79 will receive either the CBD extract or a placebo for several weeks. Researchers will track side effec…

This study tests whether a virtual reality app, used alongside standard counseling, can help people stop vaping nicotine. Ninety participants aged 16 and older who vape at least weekly and want to quit will use the VR app at home for 12 weeks. The app is designed to make practici…

This pilot study tests whether a short, peer-led counseling session can reduce binge drinking among university students in Romania. About 120 students who drink heavily will receive either a 15-20 minute motivational interview from a trained peer or no intervention. Researchers w…

This study tests whether adding a structured exercise program to cognitive-behavioral therapy (CBT) helps smokers quit more effectively than CBT alone or general health advice. Sixty-six adult smokers will be randomly assigned to one of three groups and followed for 12 weeks. Res…

This study tests whether adding neuromuscular electrical stimulation (NMES) to resistance exercises can improve muscle strength and physical performance in hospitalized patients with alcoholic liver cirrhosis who have muscle loss (sarcopenia). About 112 participants aged 47–70 wi…

This study tests whether a special breathing technique called Wim Hof breathing can improve lung function in young men who smoke e-cigarettes. Forty-two participants will practice deep breathing and breath-holding exercises. Researchers will measure lung capacity, oxygen levels, …

This study looks at how HIV and substance use disorder (SUD) affect the sense of smell and decision-making. Researchers will test 120 adults aged 18–65, including people with HIV, SUD, both, or neither. Participants will complete smell tests and computer tasks over two visits, an…

This study will give a single dose of oral methamphetamine to 20 people with HIV who are on effective antiretroviral therapy and have undetectable virus levels. The goal is to see if the drug can temporarily wake up dormant HIV hiding in cells, which could help researchers find n…

This early-stage study tests a new form of transcranial magnetic stimulation (TMS) called high-density theta burst stimulation (hdTBS) in 35 healthy adults aged 22 to 60. The goal is to check if hdTBS is safe and to compare its effects on the brain to standard TMS. Participants w…

This study looks at how different doses of THC (the active ingredient in cannabis) affect eye movements and attention. Researchers will test 40 adults—some who use cannabis often and some who use it rarely—to see if eye-tracking can reliably detect impairment. The goal is to deve…

This study aims to develop and validate a new questionnaire to measure opioid withdrawal symptoms. Researchers will work with people who have experienced opioid withdrawal to identify all possible symptoms and refine the tool through interviews and testing. The goal is to create …

This study looks at how using nicotine vapes before or after THC vapes changes the amount of THC that enters the bloodstream. Researchers will compare THC levels and effects in 60 adults who regularly use both products. The goal is to understand safety and how these products work…

This pilot study explores whether a structured approach called shared decision-making can be successfully implemented in a methadone treatment program. Shared decision-making involves clients and healthcare professionals working together to make treatment choices. The study will …

This study tests a training program called Project ECHO to help rural jails start or increase use of medications (methadone, buprenorphine, naltrexone) for opioid use disorder. Staff from 40 jails will attend online sessions with experts and peers over 18 months. Researchers will…

This study will test 70 healthy adults aged 21-55 to see how cannabis products labeled as indica, sativa, or generic affect thinking, driving, and feelings. Participants will complete memory tasks, driving simulations, and questionnaires after using cannabis. The goal is to under…

This trial asks how different e-cigarette products compare to regular cigarettes in terms of nicotine delivery and appeal. About 50 adult smokers who also use e-cigarettes will try eight different products in a random order during a supervised stay. The study measures nicotine le…

This study looks at how kratom affects people who have used opioids in the past. Researchers will compare kratom to another substance and a placebo to see how the body processes it and what effects it has. The goal is to better understand the potential risks and benefits of krato…

This pilot study will test a series of brief, private text messages sent via WhatsApp or Telegram to help people who use drugs in Kazakhstan feel more comfortable seeking PrEP, an HIV prevention pill. The messages address stigma, confidentiality worries, and misinformation. Forty…

This study develops and pilot tests a written 'practice companion' designed to help clinicians and other trusted adults provide developmentally appropriate substance use care to youth ages 14 to 24. The companion offers practical guidance on cannabis, opioids, and other substance…

This study investigates how pomegranate dietary supplements influence gut bacteria and inflammation in people with alcohol use disorder and alcohol-related liver disease. Researchers will measure levels of beneficial gut metabolites called urolithins and inflammatory markers in b…

This study tests whether adding a career counseling program called Purposeful Pathways to standard job training helps veterans with mental health and substance use disorders find and keep quality jobs. About 254 veterans from three VA sites will take part. The goal is to improve …

This study uses an anonymous online questionnaire to examine how medical students, midwifery students, and academic hospital staff use substances like alcohol, tobacco, and stimulants, and how these behaviors relate to mental health, stress, and social factors. The goal is to ide…

This study looks at whether new types of menthol cigarettes are more addictive than a person's usual menthol brand. About 48 daily smokers will test different cigarettes in a lab and at home. Researchers will measure nicotine levels in the blood and ask about how much participant…

This study looks at whether a 50-minute education session can help pregnant and new mothers taking medication for opioid use disorder, along with a friend or family member, learn more about their treatment and newborn withdrawal. Researchers will measure how many women are intere…

This study tests whether coaching prison staff can improve how methadone is provided to incarcerated people with opioid use disorder. Researchers will give individual and group coaching sessions to staff involved in security, medical care, or administration. They will measure cha…

This study tests a mobile health program called SAMU to help adults in Uganda who have HIV, high blood pressure, and mental health issues like depression or anxiety. About 1,500 participants will use their phones for mental health screening and get connected to care. The goal is …

This study looks at how men and women differ in their attraction to and addiction risk from menthol-flavored e-cigarettes, both with and without nicotine. Researchers will measure choices and effort to get the product in 60 adult smokers who already use e-cigarettes. The goal is …

This study aims to find out which cannabis warning messages are most effective at raising awareness and changing perceptions. Researchers will show US adults (both users and non-users) seven different warning messages covering topics like dependence, cognitive function, and cardi…

This study compares the immediate effects of inhaling cannabis (either smoked or vaporized) versus tobacco cigarettes on lung health. Researchers will measure breath biomarkers—such as exhaled nitric oxide, volatile organic compounds, and other substances—to see how each substanc…

This study looks at whether four new oral nicotine products (like pouches) are less appealing and addictive than traditional cigarettes and moist snuff. About 50 healthy adults who smoke and use smokeless tobacco will try each product in a clinic setting. Researchers will measure…

This study tests a web-based program for people who are worried about their romantic partner's drinking. The program teaches skills like self-care and positive communication. Researchers will first study 50 couples to understand daily patterns, then develop the program with 15 pa…

This study will test whether cannabis can reduce the desire to take opioids in people with opioid use disorder. Thirty participants will live in a hospital for six weeks and receive either cannabis or a placebo, along with opioids. Researchers will measure how many times particip…

This study looks at whether adding alcohol-related smells to virtual reality scenes makes people with alcohol use disorder feel stronger cravings. Sixty participants will experience different combinations of visual scenes (neutral or alcohol-related) and smells (none or alcohol).…

This study will test 35 people with known or suspected allergies to cannabis, tree nuts, or seeds to see if they are also allergic to hemp seeds. Participants will receive skin prick tests and blood tests to measure allergic reactions. The goal is to understand the potential alle…

This study looks at how changing the temperature and liquid in e-cigarettes affects the amount of harmful chemicals (oxidants) users breathe in. Researchers will measure markers of cell damage in breath, cheek cells, and blood from 50 adult e-cigarette users. The goal is to under…

This study is the first time MG001, a formulation of mitragynine from the kratom plant, is being tested in people. Researchers want to see if it is safe and how the body processes it. About 32 healthy adults who have used oral opioids recently will receive a single dose of MG001 …

This study aims to understand how people feel physically and mentally after they stop using drugs. Researchers will observe 120 adults aged 18-65 who have quit. The goal is to gather information, not to test a new treatment.

This study looks at how environmental factors like heat, cold, and pollution affect wounds, mental health, and drug use in homeless people in Augsburg. Researchers will compare wound care from a mobile unit to a hospital clinic, and use saliva tests to check drug use. The goal is…

This study will give 22 occasional cannabis users oral THC, CBD, both, or a placebo to measure how these substances appear in blood and saliva, and how they affect thinking and behavior. The goal is to better understand drug detection and impairment from oral cannabinoids. It is …

This pilot study tests a one-time 'booster' session for people who inject drugs and their injecting partners, given right after finishing hepatitis C treatment. The session helps them set health goals, identify barriers, and improve communication to stay engaged in ongoing health…

This study looks at adults in Dorset who visit urgent or emergency care five or more times a year. Researchers will interview patients, carers, and healthcare workers, and analyze data to understand their needs. The goal is to work with the community to design a prevention model …

This study aims to improve a short motivational conversation to help young adults (ages 18-25) who were injured in an assault and also misuse alcohol or cannabis. Researchers will interview and survey 50 participants from a hospital violence intervention program to understand how…

This study looks at how a moderate dose of THC (the active part of cannabis) affects mood, stress, and thinking in people who use cannabis at least once a week. Ninety adults will take part in two sessions—one with active cannabis and one with a placebo—without knowing which they…

This small pilot study tests a new coaching program where a person recovering from substance use disorder and a loved one each work with their own coach, then meet together as a group. The goal is to see if this approach is feasible and acceptable, and whether it improves recover…

This study aims to find better ways to help Veterans quit smoking when they come in for lung cancer screening. Since smoking causes most lung cancers, combining screening with stop-smoking support could save more lives. The project will test new processes at a few VA sites and me…

This study looks at whether adding a clinical pharmacist to community mental health teams (called FACT teams) helps people with severe mental illness and substance use disorders feel better and manage their medications more effectively. About 160 adults will take part, and the st…

This study aims to validate a virtual reality version of the Multiple Errands Test for assessing executive functions in people with alcohol use disorder. Ninety participants will complete both a real-world and a virtual supermarket task, along with other cognitive tests. The goal…

This study will check how addictive two new nicotine pouches are by measuring their effects on the body and how much nicotine gets into the blood. About 40 healthy adults who smoke and also use smokeless tobacco will try the pouches in a clinic. The goal is to understand the abus…

This study tests a web-based toolkit that helps healthcare providers screen for intimate partner violence and mental health issues in patients receiving treatment for opioid use disorder. About 792 patients and their providers will use the toolkit during routine care to see if it…

This study tests different strategies to get family members more involved when a loved one starts treatment for substance use disorder. Researchers will ask 100 family members to try and rank various engagement methods online. The goal is to find which approaches work best to hel…

This study will observe 60 adults in residential therapeutic communities in Mexico to understand how recovery from substance use unfolds over time. Participants will answer quick mobile surveys several times a day about cravings, mood, and social interactions for 8 to 12 weeks. T…

This study follows 600 offenders with both mental illness and substance abuse in Italy and California over three years. Researchers will compare community-based care in Italy with high-security hospitals in the US to see which model leads to better outcomes, like reduced violence…

This study will interview clinical staff and review patient data from an NHS alcohol care service in North West England. Researchers want to understand how acceptable the psychosocial interventions are to staff and what social or economic factors affect whether patients engage wi…

This study aims to understand how inflammation in the body influences mood and alcohol cravings in people with alcohol use disorder (AUD). Researchers will give 64 participants (32 with AUD and 32 without) a single low dose of a substance that causes temporary inflammation or a p…

This study looks at whether sharing results from a blood test that shows recent alcohol use can help people with HIV drink less. Researchers will enroll 80 people in Uganda who drink heavily. Half will get standard counseling plus their blood test results, and half will get couns…

This study will test two new services at a large Chicago health center: routine substance use screening for all patients, and a program that asks people to refer friends or partners who might need HIV or addiction care. The goal is to find more people with undiagnosed HIV or subs…

This study looks at whether a special training program can help supportive housing agencies in New York and New Jersey use proven methods to prevent overdoses and improve tenant health. About 24 agencies and 2940 people will take part. The goal is to see how well agencies adopt t…

This study tests if a 12-week one-on-one support program is easy to complete and acceptable for people supporting a loved one who recently finished substance use treatment. About 18 participants will attend weekly telehealth sessions and complete surveys and interviews. The goal …

This study compares 200 people with alcohol use disorder to healthy volunteers using questionnaires that measure psychological processes and emotional symptoms like depression and anxiety. The goal is to identify differences in how people think and cope. It is purely observationa…

This study tests a computer alert that notifies doctors when a patient is about to move into a new phase of opioid therapy, such as from short-term to long-term use. The alert prompts doctors to review the patient's pain and goals, following CDC guidelines. Researchers will study…

This study looks at whether using a stomach ultrasound before sedation can help anesthesiologists make safer decisions for chronic pain patients. These patients often take opioids or have other conditions that slow stomach emptying, raising the risk of food or liquid entering the…

This study tests whether a computer alert can help doctors identify and treat patients with opioid use disorder. About 200,000 adults will be involved, and doctors will either get an alert or not. The goal is to see if the alert increases the use of medications like buprenorphine…

This study looks at how communities can better use deflection programs—which guide people with substance use toward treatment instead of arrest. Researchers will test two community engagement strategies across 20 communities in five states. The goal is to see which approach impro…

This study tests a program called ADD'Pro that combines addiction treatment with personalized job counseling to help people with substance use disorders return to work. About 100 adults will be randomly assigned to either the ADD'Pro program or standard employment services. Resea…

This study will test a two-step screening program for advanced liver fibrosis in people with type 2 diabetes. About 1,714 patients will first get a blood test (FIB-4), and if that suggests risk, they will receive a liver stiffness measurement (transient elastography). The goal is…

This study tests a new care system for people with opioid use disorder across the University of Illinois Hospital and Clinics. Researchers want to see if it increases screening, helps patients stay in care, boosts use of addiction medications, and reduces opioid-related deaths. O…

This pilot study will test whether it is possible to run a larger trial comparing two ways to help people with alcohol use disorder. Sixty participants will either be invited to meet a therapist at the hospital for up to 10 sessions over 6 months, or receive guidance on finding a…

This study aims to adapt a proven suicide prevention program for people with alcohol use disorder in Tanzania, where mental health resources are scarce. Researchers will enroll 30 adults who drink heavily and have had recent suicidal thoughts, then test whether the telehealth int…

This study tests whether a tool called Compl-AI can predict which adults with opioid use disorder will stop their medication early. Researchers will observe 295 people receiving standard care and track their treatment attendance and adherence. The goal is to see if the model work…

This study tests whether a digital screening and brief intervention can help postpartum mothers reduce substance use. About 120 mothers enrolled in home visiting programs will complete online sessions and receive text messages. Researchers want to see which combination of digital…

This study will examine 212 regular smokers to see how their level of nicotine addiction relates to breathing strength, physical fitness, memory, pain, sleep, and overall well-being. Participants will answer questionnaires and perform simple tests like a 6-minute walk. No treatme…

This study will follow 120 people with schizophrenia who use cannabis, using mobile phone surveys and thinking tasks to track symptoms in real time. The goal is to understand how cannabis may both worsen positive symptoms (like hallucinations) and reduce negative symptoms (like l…

This study looks at how personal traits like anxiety, self-esteem, and perfectionism influence the ability to adapt in people with alcohol use disorder. Thirty participants will complete a computer task and questionnaires in one 45-minute session. No medication or treatment is in…

This study will test a new visual scale designed to help people who use methamphetamine estimate how much they use each day. Researchers will compare the scale's results with hair samples and other methods to see if it is accurate and easy to use. About 100 people aged 20-40 who …

This study looks at whether cannabidiol (CBD) can reduce the amount of THC heavy cannabis users need to feel intoxicated. About 30 adults who use cannabis heavily will take a single dose of CBD or a placebo, then inhale THC using a vaporiser and decide when they've had enough. Re…

This study will follow 90 people hospitalized with methamphetamine-induced psychotic disorder, comparing those who have also used cannabis in their lifetime to those who have not. Researchers will assess psychiatric symptoms, insight, addiction severity, and sleep quality weekly …

This study tests whether a mobile app-based program called mSTARS is practical and well-liked by adults who drink heavily and have recently been hospitalized for suicidal thoughts or behaviors. Thirty-five participants will be randomly assigned to the app, standard care, or stand…

This study looks at Link-Up, a new safe consumption room in Brussels where people can use drugs under medical supervision. Researchers will track 250 users to see if the service reduces risky behaviors like sharing needles or using in public. The goal is to understand how these r…

This study tests a program to help mental health providers prescribe smoking cessation medications to veterans with serious mental illness. Researchers will work with 65 providers and veterans to see if the program is acceptable and practical. The goal is to overcome barriers tha…

This study looks at whether a program called SBIRT (Screening, Brief Intervention, and Referral to Treatment) can be used in hospitals to help teenagers with chronic medical conditions who may be misusing alcohol. Researchers will work with hospital staff, teens, and parents to a…

This study looks at 125 hospitalized adults who have both a mental disorder and a substance use problem (dual diagnosis). Researchers want to see if things like social support and coping skills are linked to better treatment adherence and daily functioning. The goal is to find pr…

This study tests a 12-week Instagram program led by trained peers to help young adults (ages 18-25) who misuse prescription opioids. Participants will receive interactive modules and support via private Instagram groups. The goal is to see if the program is engaging, acceptable, …

This study tests a 12-week group program for HIV-negative Latino men who have sex with men and use methamphetamine. The program aims to help them cope with stigma, build resilience, and reduce meth use while also improving their interest in and use of PrEP, a medication that prev…

This study will compare obsessive-compulsive symptoms in 102 adults with substance use disorder to a similar group without it. Participants will complete interviews and questionnaires to measure OCD severity, addiction severity, and quality of life. The goal is to understand how …

This study looks at how a brief writing therapy called Written Exposure Therapy (WET) works for people with both PTSD and substance use disorders who are in residential treatment. About 108 participants will either do WET or neutral writing alongside their usual care. Researchers…

This study tests whether a brief education session about cannabis risks can increase knowledge and motivation to reduce use among people with eating disorders. 80 patients will receive either cannabis education or sleep hygiene education during their first week of a 20-week eatin…

This study looks at how different amounts of oral THC (the main psychoactive ingredient in cannabis) affect mood, heart rate, and drug feelings in healthy adults who have used cannabis before. Participants will take either a low, medium, or high dose of THC or a placebo during fo…

This study looks at how opioid use affects oxidative stress in adults. Researchers will collect blood samples and health information from 120 people taking opioids like morphine or fentanyl. No new treatments are given. The goal is to better understand the biological effects of o…

This study looks at whether a single dose of methylphenidate (Ritalin) changes how the brain responds to alcohol-related images in young adults aged 18-25 with alcohol use disorder. Participants will have brain scans and complete tasks after taking either the drug or a placebo. T…

This study will enroll 70 adult smokers to compare how appealing and addictive different e-cigarettes are versus their usual cigarettes and nicotine gum. Participants will try each product in a random order during an 8-day stay at a clinic. Researchers will measure how much nicot…

This study will measure how much nicotine enters the bloodstream when adult smokers use eight different e-cigarette products with various flavors (menthol, mint, tobacco, fruit). Forty healthy smokers, aged 21 to 60, will try each product in a random order while staying at a clin…

This study will test if simple, bedside heart tests (ultrasound, EKG, and blood tests) can accurately detect heart problems in pregnant women who regularly use methamphetamine. Researchers will compare these quick tests to a full heart ultrasound. The goal is to find a faster, ea…

This study looks at how stress and brain stimulation affect thinking and opioid cravings in 20 people with opioid use disorder who are not seeking treatment. Participants will receive either real or fake brain stimulation (rTMS) and a stress-inducing drug or placebo. Researchers …

This study will give 80 healthy adults who use cannabis occasionally different low doses of inhaled CBD (5 to 100 mg) or a placebo to see if they feel a pleasant effect. Each person will try all doses in a random order, and researchers will also explore if current tools miss any …

This pilot study will test whether an 8-session telehealth program can help people who inject drugs in the rural South build coping skills and resilience. The goal is to improve access to HIV prevention (PrEP), hepatitis C treatment, and medication for opioid use disorder. The st…

This study will check if a simple frailty score (ISAR) can predict medication problems in elderly patients visiting the emergency department. Researchers will review the medical records of 300 patients aged 75 and older, looking for inappropriate prescriptions and dangerous drug …

This study will enroll 40 healthy adult smokers to compare how much they crave different tobacco products. Participants will try heated tobacco devices, their usual cigarettes, and nicotine gum in a clinic setting. Researchers will measure their desire to smoke and nicotine level…

This study will test if a smart chatbot can help young adults (ages 18-29) who drink heavily to cut back. The chatbot will have personalized conversations to encourage healthier drinking habits. The main goal is to see if young adults find the chatbot easy and helpful to use, not…

This study tests if a special job training program helps people with substance use disorder recover better. About 50 adults in West Virginia who are in a day report program will either get the job training or standard help. Researchers will check if the training improves their re…

This study aims to develop and test a program that helps people receiving medication for opioid use disorder connect with recovery community centers. Researchers will enroll 145 adults in Massachusetts who are on buprenorphine treatment. The goal is to see if this program is feas…

This early-phase study will give 144 healthy young adults (ages 18-21) a single dose of THC (7.5 mg) or a placebo in a capsule, then use brain scans and behavioral tasks to measure how THC affects mood, reward processing, and learning. The goal is to understand why some people re…

This study tests whether community health workers can help more eligible people get screened for lung cancer and quit smoking. The workers will reach out to patients, help them make informed decisions, offer smoking cessation counseling, and navigate barriers to care. The study w…

This study tests whether a special child-resistant blister pack with clear labeling can help reduce how many opioid pills are prescribed and used after orthopedic surgery. About 352 adults will receive either the new packaging or the standard orange bottle. Researchers will track…

This study will enroll 16,000 people invited to colorectal cancer screening in Norway. Participants will fill out a diet and lifestyle questionnaire and receive personalized digital feedback on how their habits compare to health recommendations. Some groups get extra support like…