New implant could help opioid users stay clean for months
NCT ID NCT05382091
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a biodegradable implant called OLANI that slowly releases naltrexone to block the effects of opioids for weeks. Researchers will enroll 250 adults with opioid use disorder who have already completed withdrawal. Participants will receive up to four implants over about a year to see if the treatment is safe and helps prevent relapse.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
naltrexone implant (OLANI)
What this could lead to
If successful, this could provide a long-lasting, implant-based option to help people with opioid addiction avoid relapse and focus on recovery.
What could go wrong
This is an early phase II study focused on safety, not yet proven effective. Side effects from the implant or procedure, and the possibility that it may not block opioids as expected, are key risks.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.