Could cannabis ease opioid withdrawal? new study aims to find out

NCT ID NCT07661446

Not yet recruiting Disease control Sponsor: University of Kentucky Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will test whether cannabis can reduce the severity of opioid withdrawal and make opioid use safer. One hundred adults with opioid use disorder will live in a hospital for about six weeks. Researchers will give them cannabis and a small dose of opioids to see how their bodies react. The goal is to understand if cannabis can help manage withdrawal symptoms and reduce the risks of opioid use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Inhaled cannabis
What this could lead to: If it works, this could point toward a way to use cannabis to help manage opioid withdrawal and reduce the risks of opioid use.
What could go wrong: This is a very early Phase 1 study with only 100 people. It is designed to test safety and basic effects, not to prove a treatment works. The results may not lead to a new therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cannabis dependence opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANNABIS USE OPIOID USE DISORDERS

Contacts and locations

Locations

University of Kentucky

Lexington, Kentucky, 40508, United States

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