New drug may help preemies breathe easier, avoid opioids
NCT ID NCT07493785
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests dexmedetomidine, a sedative that doesn't slow breathing, in 246 premature babies on ventilators. The goal is to see if it reduces the need for opioids, shortens time on the breathing machine, and improves long-term brain development. Babies will receive the drug or a placebo for up to 20 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dexmedetomidine
What this could lead to
If it works, this could offer a safer way to sedate ventilated premature babies, reducing opioid use and potentially protecting their brain development.
What could go wrong
This is an early-to-mid stage trial with 246 babies. The drug may not reduce opioid use or improve outcomes, and side effects like low blood pressure or slow heart rate are possible.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AP-HP Hôpital Necker Enfants Malades
Paris, 75015, France
Contact Email: •••••@•••••
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CHRU Lille
Lille, 59000, France
Contact Email: •••••@•••••
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CHU Brest - Hôpital Morvan
Brest, 29609, France
Contact Email: •••••@•••••
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CHU Félix Guyon (Saint Denis)
Saint-Denis, 97400, France
Contact Email: •••••@•••••
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CHU Grenoble Alpes
Grenoble, 38700, France
Contact Email: •••••@•••••
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CHU Limoges
Limoges, 87042, France
Contact Email: •••••@•••••
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CHU de La Réunion - Site Sud Saint-Pierre
Saint-Pierre, 97400, France
Contact Email: •••••@•••••
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CHU de Nantes
Nantes, 44000, France
Contact Email: •••••@•••••
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CHU de Nice
Nice, 6200, France
Contact Email: •••••@•••••
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Centre Hospitalier Intercommunal de Créteil
Créteil, 94000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Hospitalier de Saint -Denis
Saint-Denis, 93200, France
Contact Email: •••••@•••••
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Hôpital NOVO - Site de Pontoise
Pontoise, 95300, France
Contact Email: •••••@•••••