Blood pressure drug may curb alcohol cravings in heavy drinkers

NCT ID NCT07681869

Not yet recruiting Disease control Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This study tests whether nimodipine, a blood pressure medication, can reduce alcohol consumption and craving in adults with Alcohol Use Disorder who are heavy drinkers. Participants receive nimodipine or a placebo over 18 hours, then take part in a controlled drinking session where they can choose between alcohol or money. The trial measures how many drinks they consume, their craving levels, and the stimulating or sedating effects of alcohol.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nimodipine
What this could lead to: If it works, this could point toward a medication that helps heavy drinkers cut back on alcohol by reducing craving and the stimulating effects of drinking.
What could go wrong: This is a small, early-phase trial with only 40 participants, so results may not apply to everyone. The drug is given for just 18 hours, so any effects may be short-lived.

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Conditions

The condition(s) this trial relates to.

alcohol abuse

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALCOHOL USE DISORDER

Contacts and locations

Locations

Yale University School of Medicine (Connecticut Mental Health Center)

New Haven, Connecticut, 06519, United States

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