Can brain zaps curb opioid cravings? small study to find out.
NCT ID NCT04231708
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how stress and brain stimulation affect thinking and opioid cravings in 20 people with opioid use disorder who are not seeking treatment. Participants will receive either real or fake brain stimulation (rTMS) and a stress-inducing drug or placebo. Researchers will measure changes in cognitive tasks, cravings, and stress markers to understand the brain mechanisms involved.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Yohimbine + Hydrocortisone
What this could lead to
If successful, this could point toward a non-drug way to help people with opioid use disorder manage stress and reduce cravings.
What could go wrong
This is a very small, early study (20 people) that is not yet recruiting. It tests mechanisms, not treatment effectiveness, so results may not lead to a therapy.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Tolan Park Medical Building
Detroit, Michigan, 48201, United States