New study could speed up methadone restart for opioid users

NCT ID NCT07546396

Not yet recruiting Disease control Sponsor: Pouya Azar Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a 'rapid restart' approach for people with opioid use disorder who have missed 4-8 doses of methadone. Instead of slowly increasing the dose again, participants may return to their previous stable dose right away. The goal is to see if this method is acceptable and safe, with 25 adults taking part over a 7-day follow-up.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Methadone
What this could lead to: If successful, this could make it easier and faster for people with opioid use disorder to get back on methadone treatment after missing doses, potentially reducing relapse and overdose risk.
What could go wrong: This is a very small early study (25 people) focused on feasibility, not effectiveness. The rapid restart approach may not be safe or acceptable for everyone, and results may not apply to broader populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID-USE DISORDER

Contacts and locations

Locations

Vancouver General Hospital

Vancouver, British Columbia, V5Z 1N1, Canada

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Other studies related to the condition(s) this trial covers.