Can ketamine and mindfulness break the grip of opioid addiction?

NCT ID NCT07369089

Not yet recruiting Disease control Sponsor: University of California, San Diego Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether combining ketamine-assisted psychotherapy with mindfulness training (called KetaMORE) helps people with opioid use disorder who are already on medication. 88 participants will be randomly assigned to receive either KetaMORE or ketamine with a support group. Researchers will track opioid use, cravings, and mood to see if the mindfulness approach leads to better outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ketamine
What this could lead to: If successful, this could offer a new treatment option for people with opioid use disorder who haven't responded to standard medications.
What could go wrong: This is a small, early-stage trial (88 participants) and may not show a clear benefit. Ketamine can cause side effects like dissociation and nausea, and the results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID-USE DISORDER

Contacts and locations

Locations

University Of Utah

Salt Lake City, Utah, 84112, United States
University of California, San Diego

La Jolla, California, 92093, United States

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