New hope for hardcore smokers: E-Cigs and natural pills put to the test

NCT ID NCT07274475

Not yet recruiting Disease control Sponsor: Centre for Addiction and Mental Health Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will test whether e-cigarettes or a natural supplement called cytisine can help people who smoke at least 5 cigarettes a day and haven't been able to quit with standard treatments like nicotine patches or counseling. Over 4 years, 6,000 participants will be randomly assigned to receive either an e-cigarette starter kit or a 28-day supply of cytisine. Researchers will track how many people use these options and whether they reduce their smoking or quit entirely.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: E-cigarette e-liquid and cytisine
What this could lead to: If successful, this could provide effective harm-reduction options for smokers who struggle to quit with standard methods, potentially reducing smoking-related diseases.
What could go wrong: This is a large but early-stage feasibility study, not a final test. E-cigarettes and cytisine may not help everyone quit, and long-term safety of e-cigarettes is still uncertain.

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Conditions

The condition(s) this trial relates to.

Behavior, Addictive Harm Reduction nicotine dependence Smoking Cessation Tobacco Smoking Vaping

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HARM REDUCTION NICOTINE TOBACCO SMOKING

More trials for these conditions

Other studies related to the condition(s) this trial covers.