New study aims to find safer pain relief for trauma victims

NCT ID NCT07435077

Not yet recruiting Symptom relief Sponsor: Wake Forest University Health Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will compare two pain medications, buprenorphine and oxycodone, in about 282 adults with injuries to at least two body areas. The goal is to see which provides better pain control with fewer risks. Participants will receive one of the two drugs as part of a standard pain management plan.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: buprenorphine and oxycodone
What this could lead to: If successful, this could show that buprenorphine is as effective as oxycodone for trauma pain, potentially offering a safer alternative with lower risk of opioid misuse.
What could go wrong: This is a phase 4 trial, but it's not yet recruiting and results may not apply to all trauma patients. Pain relief is subjective, and individual responses vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Acute Pain agnosia opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID-USE DISORDER

Contacts and locations

Locations

Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States

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