New IV fentanyl strategy aims to improve opioid addiction treatment
NCT ID NCT05905367
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed Phase 4 trial tested a new way to start oral opioid addiction therapy for people who use fentanyl. Participants received medically supervised IV fentanyl until comfortable, then were given tailored doses of methadone or slow-release oral morphine. The study enrolled 48 adults with opioid use disorder to see if this approach is safe and helps them stay on treatment longer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
fentanyl and methadone or slow-release oral morphine
What this could lead to
If successful, this approach could help people with severe fentanyl addiction start and stay on standard oral treatment more effectively.
What could go wrong
This is a small, completed Phase 4 trial with only 48 participants. The IV fentanyl method carries risks like sedation or breathing problems, and results may not apply to all patients.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hope to Health Research & Innovation Centre
Vancouver, British Columbia, V6A 1H2, Canada