New IV fentanyl strategy aims to improve opioid addiction treatment

NCT ID NCT05905367

Completed Disease control Sponsor: Pouya Azar Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed Phase 4 trial tested a new way to start oral opioid addiction therapy for people who use fentanyl. Participants received medically supervised IV fentanyl until comfortable, then were given tailored doses of methadone or slow-release oral morphine. The study enrolled 48 adults with opioid use disorder to see if this approach is safe and helps them stay on treatment longer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fentanyl and methadone or slow-release oral morphine
What this could lead to: If successful, this approach could help people with severe fentanyl addiction start and stay on standard oral treatment more effectively.
What could go wrong: This is a small, completed Phase 4 trial with only 48 participants. The IV fentanyl method carries risks like sedation or breathing problems, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID-USE DISORDER

Contacts and locations

Locations

Hope to Health Research & Innovation Centre

Vancouver, British Columbia, V6A 1H2, Canada

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