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Brain zaps before therapy may help kick cocaine habit

NCT ID NCT05974202

Recruiting now Disease control Sponsor: New York State Psychiatric Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This study tests whether a non-invasive brain stimulation technique called rTMS, given before cognitive-behavioral therapy, can help adults with cocaine use disorder quit. Thirty participants will receive either real or sham rTMS daily for 3 weeks, followed by 12 weeks of weekly therapy. The goal is to see if the combination is safe, feasible, and leads to abstinence.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
repetitive transcranial magnetic stimulation (rTMS)
What this could lead to
If it works, this could point toward a new way to boost therapy for cocaine addiction, helping people stay abstinent.
What could go wrong
This is a very small early-stage trial (30 people) testing feasibility and brain effects, not yet proven to work. The sham group also gets therapy, so the added benefit of rTMS may be small or none.

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Conditions

The condition(s) this trial relates to.

cocaine abuse cocaine dependence Cocaine-Related Disorders follicular lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COCAINE DEPENDENCE COCAINE USE COCAINE USE DISORDER COCAINE USE DISORDER, MODERATE COCAINE USE DISORDER, SEVERE

Contacts and locations

Locations

  • New York State Psychiatric Institute (NYSPI) / Substance Treatment and Research Service (STARS)

    RECRUITING

    New York, New York, 10019, United States

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