Can a Cannabis-Derived drug ease pain without raising opioid risks?
NCT ID NCT04025359
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial at Yale tests whether dronabinol (Marinol), a synthetic form of THC, can reduce pain sensitivity and improve attention and mood in 36 adults with opioid use disorder who are stable on methadone or buprenorphine. Participants receive either 2.5 mg, 5 mg of dronabinol, or a placebo before their daily opioid dose. The study measures pain via cold and heat tests, questionnaires, and cognitive tasks, with a one-week follow-up for safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dronabinol (Marinol)
What this could lead to
If it works, this could point toward a way to manage pain in people on opioid maintenance therapy without increasing opioid use.
What could go wrong
This is a very small, early-phase study with only 36 participants, so results may not apply broadly. Dronabinol can cause side effects like dizziness or confusion.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-••••
Locations
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VA Connecticut Healthcare System
RECRUITINGWest Haven, Connecticut, 06516, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••