New drug aims to curb alcohol cravings in major trial

NCT ID NCT07219966

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 07, 2026 · Updated 7 times

Summary

This phase 3 study tests whether brenipatide can help adults with moderate-to-severe alcohol use disorder drink less and feel less urge to drink. About 1,100 motivated participants will receive either the drug or a placebo for 56 weeks. The main goal is to see changes in drinking patterns and cravings.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: brenipatide
What this could lead to: If it works, this could provide a new medication option to help people with alcohol use disorder reduce their drinking and cravings.
What could go wrong: This is a late-stage trial, but the drug may still fail to show meaningful benefit over placebo. Side effects or lack of long-term effectiveness are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alcohol abuse

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALCOHOL USE DISORDER

Contacts and locations

Locations

ANIMA Research
RECRUITING

Diepenbeek, 3590, Belgium
Accel Research Sites - Lakeland Clinical Research Unit
RECRUITING

Lakeland, Florida, 33803, United States
Adams Clinical Boston
RECRUITING

Boston, Massachusetts, 02116, United States
Adams Clinical Bronx
RECRUITING

The Bronx, New York, 10461, United States
Adams Clinical Dallas
RECRUITING

DeSoto, Texas, 75115, United States
Ai Sakura Clinic
ACTIVE_NOT_RECRUITING

Fukuoka, 810-0001, Japan
Alpine Research Organization
RECRUITING

Clinton, Utah, 84015, United States
Arata Clinic
ACTIVE_NOT_RECRUITING

Nagasaki, 852-8137, Japan
Artemis Institute for Clinical Research
RECRUITING

San Diego, California, 92123, United States
Avera Research Institute - Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57108, United States
Beijing Anding Hospital - Affiliated Capital University of Medical Science
RECRUITING

Beijing, 100088, China
Beijing HuiLongGuan Hospital
RECRUITING

Beijing, 100096, China
Chang Gung Medical Foundation-Linkou Branch
RECRUITING

Taoyuan, 333, Taiwan
Charter Research - Orlando
RECRUITING

Orlando, Florida, 32803, United States
China Medical University Hospital
RECRUITING

Taichung, 404332, Taiwan
Chungbuk National University Hospital
RECRUITING

Cheongju-si, 28644, South Korea
Clerkenwell Health - London - Baker Street
RECRUITING

London, W1U 6RP, United Kingdom
Dedicated Research Site FutureMeds
RECRUITING

Offenbach, 63065, Germany
Edinburgh Royal Infirmary
RECRUITING

Edinburgh, EH16 4SA, United Kingdom
First Affiliated Hospital of Kunming Medical University
RECRUITING

Kunming, 650032, China
FutureMeds GmbH
RECRUITING

Berlin, 10629, Germany
Gachon University Gil Medical Center
RECRUITING

Namdong-gu, 21565, South Korea
Gezondheidshuis De Gloed
RECRUITING

Machelen, 9870, Belgium
Greater Manchester Mental Health NHS Foundation Trust
RECRUITING

Manchester, M25 3BL, United Kingdom
Guangzhou Brain Hospital
RECRUITING

Guangzhou, 510370, China
Hallym University Sacred Heart Hospital
RECRUITING

Anyang-si, 14068, South Korea
Hanyang University Guri Hospital
RECRUITING

Guri-si, 11923, South Korea
Hanyang University Seoul Hospital
RECRUITING

Seoul, 04763, South Korea
Headlands Research - Scottsdale
RECRUITING

Scottsdale, Arizona, 85260, United States
Higashi Shinjuku Clinic
ACTIVE_NOT_RECRUITING

Shinjuku-ku, 169-0072, Japan
Hillside Clinic Jingumae
ACTIVE_NOT_RECRUITING

Shibuya City, 150-0001, Japan
Hiro Mental Clinic
ACTIVE_NOT_RECRUITING

Fukuoka, 810-0004, Japan
Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
RECRUITING

Hualien City, 970, Taiwan
Huzhou Third Municipal Hospital
RECRUITING

Huzhou, 313000, China
K2 Medical Research - Foxborough
RECRUITING

Foxborough, Massachusetts, 02035, United States
K2 Medical Research - Maitland
RECRUITING

Maitland, Florida, 32751, United States
K2 Medical Research - Tampa
RECRUITING

Tampa, Florida, 33634, United States
K2 Medical Research ORLANDO
RECRUITING

Maitland, Florida, 32751, United States
Kaedenomori Mental Clinic
ACTIVE_NOT_RECRUITING

Shibuya City, 150-0022, Japan
Kariya Hospital
ACTIVE_NOT_RECRUITING

Kariya, 448-0851, Japan
Keiai Clinic
ACTIVE_NOT_RECRUITING

Shinjuku-ku, 160-0004, Japan
Klinische Forschung Dresden
RECRUITING

Dresden, 01069, Germany
Klinische Forschung Hamburg
RECRUITING

Hamburg, 20253, Germany
Klinische forschung Schwerin GmbH
RECRUITING

Schwerin, 19055, Germany
Konyang University Hospital
RECRUITING

Seogu, 35365, South Korea
Konyang University Hospital
RECRUITING

Seogu, 35365, South Korea
Kormont
RECRUITING

Kluisbergen, 9690, Belgium
Kuramitsu Hospital
ACTIVE_NOT_RECRUITING

Fukuoka, 819-0037, Japan
Kyungpook National University Hospital
RECRUITING

Junggu, 41944, South Korea
Layton Medical Centre
RECRUITING

Blackpool, FY3 7EN, United Kingdom
Life Arc Research Centers - Miami
RECRUITING

Miami, Florida, 33126, United States
Life Medical Research Group Corp
RECRUITING

Miami Gardens, Florida, 33014, United States
Mackay Memorial Hospital
RECRUITING

Taipei, 10449, Taiwan
Maekawa Medical Clinic
ACTIVE_NOT_RECRUITING

Yokohama, 220-0004, Japan
Maryland Treatment Centers - Avery Road Treatment Center
RECRUITING

Rockville, Maryland, 20853, United States
Maryland Treatment Centers - Mountain Manor Treatment Center
RECRUITING

Baltimore, Maryland, 21229, United States
Meclinas
RECRUITING

Mechelen, 2800, Belgium
Medisch Centrum Saffrou
RECRUITING

Oudenaarde, 9636, Belgium
Mountain Mind - Denver
RECRUITING

Denver, Colorado, 80202, United States
National Hospital Organization Hizen Psychiatric Medical Center
ACTIVE_NOT_RECRUITING

Yoshinogari-cho, Kanzaki-gun, 842-0192, Japan
National Institute for Health Research (NIHR) - King's Clinical Research Facility (CRF)
RECRUITING

London, SE5 9RS, United Kingdom
Noguchi Naika Clinic
ACTIVE_NOT_RECRUITING

Tokyo, 165-0031, Japan
North Star Medical Research
RECRUITING

Middleburg Heights, Ohio, 44130, United States
Parkway Medical Center
NOT_YET_RECRUITING

Birmingham, Alabama, 35215, United States
Penn Medicine: University of Pennsylvania Health System
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Pillar Clinical Research - Richardson
RECRUITING

Richardson, Texas, 75080, United States
Psychiatric Hospital of Henan Province
RECRUITING

Xinxiang, 453003, China
Pusan National University Yangsan Hospital
RECRUITING

Busan, 50612, South Korea
Queen Elizabeth University Hospital
RECRUITING

Glasgow, G51 4TF, United Kingdom
Rainbow and Sea Hospital
ACTIVE_NOT_RECRUITING

Karatsu, 847-0031, Japan
Re:Cognition Health
RECRUITING

Fairfax, Virginia, 22031, United States
Re:Cognition Health - Chicago
RECRUITING

Chicago, Illinois, 60611, United States
Sakurazaka Clinic SophyAnce
ACTIVE_NOT_RECRUITING

Tokyo, 106-0032, Japan
Samoncho Clinic
ACTIVE_NOT_RECRUITING

Shinjuku, 160-0017, Japan
Sangenjaya Shinkeika Shinryonaika Clinic
ACTIVE_NOT_RECRUITING

Setagaya City, 154-0004, Japan
Seoul National University Bundang Hospital
RECRUITING

Seongnam, 13620, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Shandong Mental Health Center
RECRUITING

Jinan, 250012, China
Shanghai Mental Health Center
RECRUITING

Shanghai, 200030, China
Shenzhen Kangning Hospital
RECRUITING

Shenzhen, 518003, China
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
RECRUITING

Hangzhou, 310016, China
Southampton General Hospital
RECRUITING

Southampton, SO16 6YD, United Kingdom
St Pancras Clinical Research
RECRUITING

London, EC2Y 8EA, United Kingdom
St Pancras Clinical Research - Chester
RECRUITING

Chester, CH2 1HX, United Kingdom
St Pancras Clinical Research - Eastbourne
RECRUITING

Eastbourne, BN23 5UZ, United Kingdom
Taipei City Hospital - Songde Branch
RECRUITING

Taipei, 110204, Taiwan
Tatsuta Clinic
ACTIVE_NOT_RECRUITING

Kobe, 651-0097, Japan
The Affiliated hospital of Southwest Medical University
RECRUITING

Sichuan, 646000, China
The Affilicated Kangning Hospital of Ningbo University
RECRUITING

Ningbo, 315201, China
The Catholic Univ. of Korea Seoul St. Mary's Hospital
RECRUITING

Seoul, 06591, South Korea
The Catholic University of Korea, Uijeongbu St. Mary's Hospital
RECRUITING

Uijeongbu-si, 11765, South Korea
The First Affiliated Hospital of Nanchang University
RECRUITING

Nanchang, 330006, China
The First Hospital of Hebei Medical University
RECRUITING

Shijiazhuang, 050031, China
The Fourth Hospital of Harbin Medical University
RECRUITING

Harbin, 150001, China
The Fourth People's Hospital of Chengdu
RECRUITING

Chengdu, 610036, China
The Second People's Hospital of Hunan Province
RECRUITING

Changsha, 410007, China
The Second Xiangya Hospital of Central South University
RECRUITING

Changsha, 410011, China
The Seventh People's Hospital of Hangzhou
RECRUITING

Hangzhou, 310000, China
The Third Hospital of Mianyang
RECRUITING

Mianyang, 621000, China
Tianjin Anding Hospital
RECRUITING

Tianjin, 300022, China
Tokyo-Eki Center-building Clinic
ACTIVE_NOT_RECRUITING

Chūōku, 103-0027, Japan
Tri-Service General Hospital
RECRUITING

Taipei, 114, Taiwan
Tsukuba University Hospital
ACTIVE_NOT_RECRUITING

Tsukuba, 305-8576, Japan
UCLA Clinical & Translational Research Center (CTRC)
RECRUITING

Los Angeles, California, 90095, United States
UCSF Weill Institute for Neurosciences - Substance Use Disorders Clinic - Mission Bay
RECRUITING

San Francisco, California, 94158, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University of Washington Medical Center - Montlake
RECRUITING

Seattle, Washington, 98195, United States
Velocity Clinical Research, Berlin
RECRUITING

Berlin, 10787, Germany
Wellness Research Center
RECRUITING

Miami, Florida, 33135, United States
West China Hospital, Sichuan University
RECRUITING

Cheng Du Shi, 610041, China
Woodland International Research Group
RECRUITING

Little Rock, Arkansas, 72211, United States
Wuhu Hospital of Beijing Anding hospital
RECRUITING

Wuhu, 242407, China
Xi An Mental Health Center
RECRUITING

Xi'an, 710061, China
Xiamen Xianyue Hospital
RECRUITING

Xiamen, 361012, China
Xianyang Hospital of Yan'an University
RECRUITING

Xianyang, 712000, China
Yokogawa Ekimae Clinic
ACTIVE_NOT_RECRUITING

Nishi, 733-0011, Japan
Zentralinstitut für Seelische Gesundheit
RECRUITING

Mannheim, 68159, Germany
Zhenjiang Mental Health Center
RECRUITING

Zhenjiang, 212000, China

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