Scientists test synthetic nicotine and new Nicotine-Like chemicals in vapers

NCT ID NCT07348224

Recruiting now Knowledge-focused Sponsor: Insel Gruppe AG, University Hospital Bern Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 07, 2026 · Updated 6 times

Summary

This study will compare how synthetic nicotine and a nicotine analogue (6-methylnicotine) behave in the body versus traditional tobacco-derived nicotine. Twenty-four regular vapers will vape e-liquids containing these substances, and researchers will measure their levels in the blood and their effects. The goal is to understand if these newer products work the same way as standard nicotine.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: synthetic nicotine (S-nicotine, racemic nicotine) and nicotine analogue 6-methylnicotine
What this could lead to: If successful, this could clarify whether synthetic nicotine and nicotine analogues work like traditional nicotine, informing regulation and product safety.
What could go wrong: This is a small, early-phase study (24 people) that only measures short-term effects. Results may not apply to long-term use or broader populations.

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Conditions

The condition(s) this trial relates to.

nicotine dependence Vaping

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NICOTINE NICOTINE ANALOGUES SYNTHETIC NICOTINE VAPING

Contacts and locations

Locations

Inselspital
RECRUITING

Bern, Switzerland

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