Can this IV drug help avoid liver transplants in heavy drinkers?

NCT ID NCT07428538

Recruiting now Disease control Sponsor: Bausch Health Americas, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This Phase 3 trial tests an experimental drug called larsucosterol in 350 people with severe alcohol-associated hepatitis. The goal is to see if the drug helps patients survive for 90 days without needing a liver transplant. Participants receive either the drug or a placebo by IV, and researchers track survival, hospital stays, and overall health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: larsucosterol (also called DUR928 or DV928), given as an intravenous infusion
What this could lead to: If it works, this could provide a new treatment to help people with severe alcohol-related hepatitis survive without needing a liver transplant.
What could go wrong: This is a late-stage trial, but the condition is very serious and hard to treat. The drug may not improve survival or could have side effects. Results are still pending.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alcoholic hepatitis hepatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATITIS

Contacts and locations

Locations

AdventHealth Medical Campus
NOT_YET_RECRUITING

Tampa, Florida, 33602, United States
AdventHealth Transplant Institute
NOT_YET_RECRUITING

Orlando, Florida, 32804, United States
Augusta University
NOT_YET_RECRUITING

Augusta, Georgia, 30901, United States
Banner - University Medical Center, Phoenix, Arizona
RECRUITING

Phoenix, Arizona, 85006, United States
Baylor College of Medicine (BCM) - Baylor Clinic
RECRUITING

Houston, Texas, 77030, United States
Baylor Scott & White All Saints Medical Center - Forth Worth
NOT_YET_RECRUITING

Fort Worth, Texas, 76104, United States
Baylor Scott White Research Institute - Dallas
NOT_YET_RECRUITING

Dallas, Texas, 75246, United States
Baylor Scott White Research Institute - Temple
NOT_YET_RECRUITING

Temple, Texas, 76501, United States
Beth Israel Deaconess Medical Center
NOT_YET_RECRUITING

Boston, Massachusetts, 02215, United States
Bon Secours Liver Institute of Richmond
RECRUITING

Richmond, Virginia, 23226, United States
Boston University School of Medicine
NOT_YET_RECRUITING

Boston, Massachusetts, 02118, United States
Cedars Sinai Medical Center
NOT_YET_RECRUITING

Los Angeles, California, 90048, United States
Cleveland Clinic
NOT_YET_RECRUITING

Cleveland, Ohio, 44114, United States
Clinical Trial Network - Houston
NOT_YET_RECRUITING

Houston, Texas, 77002, United States
Columbia University Medical Center (CUMC) - Presbyterian Hospital and Vanderbilt Clinic
NOT_YET_RECRUITING

New York, New York, 10007, United States
Duke University Hospital
NOT_YET_RECRUITING

Durham, North Carolina, 27710, United States
Einstein Medical Center Philadelphia
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Galen Medical Group - Galen Hepatology
NOT_YET_RECRUITING

Chattanooga, Tennessee, 37402, United States
Georgetown University Medical Center
NOT_YET_RECRUITING

Washington D.C., District of Columbia, 20007, United States
Henry Ford Hospital System
NOT_YET_RECRUITING

Detroit, Michigan, 48202, United States
Indiana Institute for Medical Research (Indiana VA)
NOT_YET_RECRUITING

Indianapolis, Indiana, 46204, United States
Intermountain Transplant Clinic
NOT_YET_RECRUITING

Murray, Utah, 84107, United States
Johns Hopkins Hospital
NOT_YET_RECRUITING

Baltimore, Maryland, 21287, United States
Levine Cancer Institute / Atrium Health
NOT_YET_RECRUITING

Charlotte, North Carolina, 28204, United States
Loyola University Medical Center (LUMC)
NOT_YET_RECRUITING

Maywood, Illinois, 60153, United States
Maine Medical Center - Bramhall Campus
NOT_YET_RECRUITING

Portland, Maine, 04102-3134, United States
Marshall Health
NOT_YET_RECRUITING

Huntington, West Virginia, 25701, United States
Massachusetts General Hospital
NOT_YET_RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
NOT_YET_RECRUITING

Jacksonville, Florida, 32202, United States
Mayo Clinic - Phoenix
NOT_YET_RECRUITING

Phoenix, Arizona, 85054, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Mercy Medical Center - The Institute for Digestive Health and Liver Disease
RECRUITING

Baltimore, Maryland, 21202, United States
Methodist Healthcare - Methodist Hospital Specialty and Transplant
NOT_YET_RECRUITING

San Antonio, Texas, 78205, United States
Montefiore Medical Center
NOT_YET_RECRUITING

The Bronx, New York, 10467, United States
NYU Langone Health
NOT_YET_RECRUITING

New York, New York, 10016, United States
North Texas Gastroenterology
NOT_YET_RECRUITING

Denton, Texas, 76201, United States
Northwell Health Physician Partners Sandra Atlas Bass Center for Liver Diseases
RECRUITING

Manhasset, New York, 11030, United States
Northwestern University - Feinberg School of Medicine
NOT_YET_RECRUITING

Chicago, Illinois, 60601, United States
Oregon Health & Science University
NOT_YET_RECRUITING

Portland, Oregon, 97204, United States
Penn State Health, Milton S. Hershey Medical Center
NOT_YET_RECRUITING

Hershey, Pennsylvania, 17033, United States
Piedmont Atlanta Hospital - Piedmont Transplant Institute
RECRUITING

Atlanta, Georgia, 30309, United States
Ralph H. Johnson Department of Veterans Affairs Medical Center
NOT_YET_RECRUITING

Charleston, South Carolina, 29401, United States
Reliant Medical Research
NOT_YET_RECRUITING

Miami, Florida, 33131, United States
Richmond VA Medical Center
RECRUITING

Richmond, Virginia, 23249, United States
Robley Rex VA Medical Center
NOT_YET_RECRUITING

Louisville, Kentucky, 40206, United States
Rush University Medical Center
NOT_YET_RECRUITING

Chicago, Illinois, 60612, United States
Rutgers University New Jersey Medical School
NOT_YET_RECRUITING

Newark, New Jersey, 07103-2425, United States
Saint Luke's Hospital of Kansas City
NOT_YET_RECRUITING

Kansas City, Missouri, 64106, United States
Scripps
NOT_YET_RECRUITING

La Jolla, California, 92037, United States
Southern California GI & Liver Centers - Coronado
NOT_YET_RECRUITING

Coronado, California, 92118, United States
Stanford Medicine - Clinical and Translational Research Unit - Redwood City
NOT_YET_RECRUITING

Redwood City, California, 94063, United States
Sutter Health
NOT_YET_RECRUITING

San Francisco, California, 94109, United States
Swedish Medical Center
NOT_YET_RECRUITING

Seattle, Washington, 98101, United States
Tampa General Hospital
NOT_YET_RECRUITING

Tampa, Florida, 33606, United States
Temple University Hospital
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19140, United States
The Liver Institute at Methodist Dallas Medical Center
RECRUITING

Dallas, Texas, 75203, United States
The Ohio State University Wexner Medical Center (OSUWMC)
RECRUITING

Columbus, Ohio, 43210, United States
Thomas Jefferson University Hospital
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Tufts Medical Center
NOT_YET_RECRUITING

Boston, Massachusetts, 02108, United States
Tulane University Health Sciences Center - Tulane Avenue
RECRUITING

New Orleans, Louisiana, 70112, United States
UCLA Health - Ronald Reagan Medical Center
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States
UMass Chan Medical School
NOT_YET_RECRUITING

Worcester, Massachusetts, 01655, United States
UW Medicine-Harborview Medical Center
NOT_YET_RECRUITING

Seattle, Washington, 98101, United States
University Hospitals Cleveland Medical Center
NOT_YET_RECRUITING

Cleveland, Ohio, 44106, United States
University of Alabama at Birmingham (UAB) Hospital
RECRUITING

Birmingham, Alabama, 35294, United States
University of California at Davis Medical Center
NOT_YET_RECRUITING

Sacramento, California, 95757, United States
University of Iowa Hospitals & Clinics
RECRUITING

Iowa City, Iowa, 52242, United States
University of Kentucky -Chandler Medical Center
NOT_YET_RECRUITING

Lexington, Kentucky, 40507, United States
University of Miami
NOT_YET_RECRUITING

Miami, Florida, 33131, United States
University of Michigan
NOT_YET_RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Minnesota Medical Center
NOT_YET_RECRUITING

Minneapolis, Minnesota, 55414-2924, United States
University of Nevada Las Vegas
NOT_YET_RECRUITING

Las Vegas, Nevada, 89101, United States
University of New Mexico (UNM) Hospital
NOT_YET_RECRUITING

Albuquerque, New Mexico, 87106-4713, United States
University of Pennsylvania Hospital
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15222, United States
University of Rochester Medical Center
NOT_YET_RECRUITING

Rochester, New York, 14604, United States
University of South Alabama
NOT_YET_RECRUITING

Mobile, Alabama, 36602, United States
University of Utah Health - University of Utah
NOT_YET_RECRUITING

Salt Lake City, Utah, 84132, United States
University of Virginia Health
RECRUITING

Charlottesville, Virginia, 22908, United States
University of Wisconsin-Madison
NOT_YET_RECRUITING

Madison, Wisconsin, 53703, United States
VA Medical Center - Philadelphia
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19104-4551, United States
Vanderbilt University Medical Center
NOT_YET_RECRUITING

Nashville, Tennessee, 37219, United States
Virtua Medical Group (VMG) - Virtua Center for Liver Disease - Toms River
NOT_YET_RECRUITING

Camden, New Jersey, 08102, United States
Yale School of Medicine
NOT_YET_RECRUITING

New Haven, Connecticut, 06510, United States

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