Xanax and opioids: new study tests safety and abuse risk
NCT ID NCT06757140
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing how the drugs alprazolam (Xanax) and oxycodone (an opioid) interact when taken together. Researchers will give small, non-therapeutic doses to 25 healthy adults who already use these drugs. They will measure how much participants like the drug combination, any side effects, and how the drugs move through the body. The goal is to better understand the safety and abuse potential of mixing these medications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
alprazolam (Xanax) and oxycodone (Percocet, Roxicodone)
What this could lead to
If successful, this could help doctors understand the risks of combining these drugs, leading to safer prescribing guidelines.
What could go wrong
This is an early-phase study with only 25 participants, so results may not apply to everyone. The drugs are given experimentally and may cause side effects like drowsiness or breathing problems.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for DRUG INTERACTIONS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
University of Kentucky
RECRUITINGLexington, Kentucky, 40508, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact