Grapefruit juice tested for impact on depression drug

This study aims to understand how common substances like grapefruit juice and another medication affect how the body processes esketamine, a drug used for depression and pain. Researchers gave 12 healthy volunteers esketamine either as a nasal spray or by mouth, along with either grapefruit juice, the drug cobicistat, or water. They measured the drug levels in the blood over 24 hours to see if these substances change how much esketamine the body absorbs.