Could a common heart pill curb alcohol cravings?
NCT ID NCT05807139
First seen Jun 27, 2026 · Last updated Aug 04, 2026 · Updated 5 times
Summary
This early-phase study tests whether spironolactone, a drug currently used for high blood pressure and heart failure, can be safely used in people with alcohol use disorder. Twenty participants will each stay at a clinic four times, taking either the drug or a placebo for five days, then drinking alcohol in a controlled setting. Researchers will measure how the body processes the drug and alcohol, and check for side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Spironolactone
- What this could lead to
- If this early study shows that spironolactone is safe and reduces alcohol craving or consumption, it could point toward a new treatment option for alcohol use disorder.
- What could go wrong
- This is a very small Phase 1b safety and dosing study with only 20 participants. It is not designed to prove effectiveness, and the drug may not reduce drinking in real-world settings. Side effects like high potassium or kidney issues are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
National Institute on Drug Abuse
RECRUITINGBaltimore, Maryland, 21224, United States
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