Brain training may ease opioid addiction by rewiring memory

NCT ID NCT06643988

Recruiting now Symptom relief Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This study tests whether a four-week at-home memory training program called MemFlex can improve symptoms and brain function in people with opioid use disorder. Participants complete memory exercises and undergo brain and heart monitoring before and after training. The goal is to understand how memory relates to addiction and whether this approach can lead to better outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MemFlex (cognitive training exercises)
What this could lead to: If it works, this could point toward a non-drug therapy to help people with opioid use disorder manage cravings and improve daily life.
What could go wrong: This is a small, early study with no placebo group, so results may not be generalizable. The training is experimental for this condition and may not produce meaningful benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID USE DISORDER

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact

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