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New sleep drug could help those battling opioid addiction

NCT ID NCT06655883

Recruiting now Symptom relief Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This study tests whether suvorexant, a sleep medication, can help people with opioid use disorder fall asleep and stay asleep. About 300 participants will receive either suvorexant or a placebo. The goal is to see if the drug improves total sleep time and is safe to use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
suvorexant
What this could lead to
If it works, this could provide a safe, effective sleep aid for people with opioid use disorder who struggle with insomnia.
What could go wrong
This is a phase 3 trial, but insomnia treatments often have mixed results. Suvorexant may not work better than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

insomnia opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INSOMNIA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Adams Clinical Dallas ( Site 2007)

    RECRUITING

    DeSoto, Texas, 75115, United States

  • Butler Hospital ( Site 1002)

    RECRUITING

    Providence, Rhode Island, 02906, United States

  • CenExel iResearch, LLC ( Site 2010)

    RECRUITING

    Savannah, Georgia, 31405, United States

  • Cenexel CNS ( Site 2012)

    RECRUITING

    Garden Grove, California, 92845, United States

  • Hassman Research Institute Marlton Site ( Site 2005)

    RECRUITING

    Marlton, New Jersey, 08053, United States

  • Johns Hopkins University ( Site 1001)

    RECRUITING

    Baltimore, Maryland, 21224, United States

  • Medical University of South Carolina ( Site 1005)

    RECRUITING

    Charleston, South Carolina, 29403, United States

  • Memorial Hermann Village ( Site 2001)

    RECRUITING

    Houston, Texas, 77043, United States

  • Penn Medicine University of Pennsylvania Health System- Center for Studies of Addiction ( Site 1006)

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • The Rivus Wellness & Research Institute ( Site 2014)

    RECRUITING

    Oklahoma City, Oklahoma, 73112, United States

  • VCU Institute for Drug and Alcohol Studies ( Site 1004)

    RECRUITING

    Richmond, Virginia, 23219, United States

  • Yale University School of Medicine ( Site 1003)

    RECRUITING

    New Haven, Connecticut, 06520, United States

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