Ultrasound-MRI fusion could sharpen cancer radiation targeting

NCT ID NCT05977621

Recruiting now Knowledge-focused Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early study at Duke University is testing whether combining transrectal ultrasound (TRUS) images with MRI scans can help doctors guide needles more accurately during brachytherapy for uterine cancer. The researchers will enroll 17 adults with uterine or cervical cancer who are scheduled for radiation therapy. The goal is simply to see if the images can be fused successfully, not yet to measure any treatment benefit.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transrectal ultrasound (TRUS) imaging
What this could lead to: If successful, this could lead to a more precise needle guidance system for brachytherapy, potentially improving treatment accuracy for uterine cancer.
What could go wrong: This is a very early, small pre-feasibility study with only 17 participants. It only tests image fusion, not treatment outcomes, so it may not lead to a usable clinical tool.

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Conditions

The condition(s) this trial relates to.

cervical carcinoma endometrium adenocarcinoma uterine cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

UTERINE CANCER

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Duke Cancer Center
RECRUITING

Durham, North Carolina, 27710, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••

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