Can new tracers make many cancers light up on scans?
NCT ID NCT04147494
First seen Aug 21, 2026 · Last updated Aug 21, 2026
Summary
This early-phase trial explores whether two experimental PET/CT tracers, 68Ga-FAPI-46 and 68Ga-PSMA-11, can accurately highlight various non-prostate cancers, including breast, lung, and pancreatic tumors. Participants scheduled for surgery will receive the tracers before their scans, and the images will be compared with the removed tumor tissue to see if the tracers truly mark cancer cells. The study aims to determine where these tracers accumulate in the body and whether they could offer a new imaging tool for diagnosing and guiding treatment of these cancers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Two experimental PET imaging tracers, gallium Ga 68 FAPI-46 and gallium Ga 68-labeled PSMA-11, given intravenously before a PET/CT scan.
- What this could lead to
- If successful, these tracers could provide a new way to visualize a wide range of cancers, potentially improving detection and surgical planning.
- What could go wrong
- This is a very early, small exploratory study. The tracers may not accumulate consistently across all cancer types, and results may not translate to routine clinical use.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Ethan Lam
Los Angeles, California, 90095, United States
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