Can a Three-Drug cocktail shrink esophageal tumors before surgery?
NCT ID NCT07780721
First seen Aug 21, 2026 · Last updated Aug 21, 2026
Summary
This phase 2 trial is testing whether giving a combination of adebrelimab (an immunotherapy), thymalfasin (an immune booster), and chemotherapy before surgery can improve outcomes for people with resectable esophageal squamous cell carcinoma. The study will enroll about 31 adults in China who will receive 2-3 cycles of the combination, followed by surgery. The main goal is to see how often the tumor completely disappears after this pre-surgical treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- A combination of adebrelimab (an immunotherapy drug), thymalfasin (an immune-boosting peptide), and chemotherapy (nab-paclitaxel plus either cisplatin or carboplatin), given before surgery.
- What this could lead to
- If successful, this approach could improve the chances of eliminating the tumor before surgery, potentially leading to better long-term outcomes for people with esophageal cancer.
- What could go wrong
- This is an early-phase, small study (31 participants) without a comparison group, so results may not be definitive. The combination may increase side effects, and the added benefit of thymalfasin is uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Affiliated Hospital of Putian University
Putian, Fujian, 351100, China
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