Can focused radiation boost Immunotherapy's power against advanced cancer?

NCT ID NCT07770100

First seen Aug 18, 2026 ยท Last updated Aug 18, 2026

Summary

This phase II trial is testing whether adding a type of precise radiation called stereotactic body radiation therapy (SBRT) to standard immunotherapy can help people with stage IV cancers, including head and neck, lung, cervical, esophageal, and gastric cancers. Participants will receive SBRT to several metastatic spots during their first cycle of an immune checkpoint inhibitor like pembrolizumab or nivolumab. The main question is whether this combination can delay cancer progression for at least six months, while researchers also monitor side effects and overall survival.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
Stereotactic body radiation therapy (SBRT) combined with FDA-approved immune checkpoint inhibitors (pembrolizumab, nivolumab, atezolizumab, ipilimumab)
What this could lead to
If successful, this approach could extend the time that people with stage IV cancers live without their disease progressing, potentially improving overall survival.
What could go wrong
This is a small, early-phase study, and the added radiation may increase side effects. The benefit is uncertain and may not apply to all patients or cancer types.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of Kentucky Markey Cancer Center

    Lexington, Kentucky, 40536, United States

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