Can Real-World data confirm T-DXd's promise in HER2-Mutant lung cancer?
NCT ID NCT06809764
First seen Aug 18, 2026 · Last updated Aug 18, 2026
Summary
This observational study is looking at how well the drug trastuzumab deruxtecan (T-DXd) works and how safe it is in Chinese patients with advanced non-small cell lung cancer that has a specific HER2 mutation. Researchers will follow about 150 patients who are already receiving T-DXd as part of their normal care, tracking how long they live without the cancer growing and any side effects they experience. The goal is to see if the benefits seen in clinical trials hold up in everyday practice.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- trastuzumab deruxtecan (T-DXd), an antibody-drug conjugate, observed in routine clinical practice
- What this could lead to
- If successful, this study could provide real-world evidence on how well T-DXd works and its safety in Chinese patients with HER2-mutant lung cancer, potentially guiding treatment decisions.
- What could go wrong
- As an observational study, it cannot prove cause and effect, and results may be influenced by patient selection and real-world variability. Safety and effectiveness may differ from clinical trial findings.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Affiliated Cancer Hospital and Institute of Guangzhou Medical University
RECRUITINGGuangzhou, 510060, China
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Affiliated Hospital of Nantong University
RECRUITINGJiangsu, 226001, China
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Anhui Provincial Cancer Hospital
RECRUITINGHefei, 230031, China
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Beijing Cancer Hospital
RECRUITINGBeijing, 100142, China
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Beijing Chest Hospital, Capital Medical University
RECRUITINGBeijing, 101149, China
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Cancer Hospital Chinese Academy of Medical Sciences
NOT_YET_RECRUITINGBeijing, 100021, China
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Cancer Hospital Chinese Academy of Medical Sciences （Langfang Section)
RECRUITINGHebei, 065000, China
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Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen Center
RECRUITINGShenzhen, 518116, China
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Cancer Hospital of Shandong First Medical University
NOT_YET_RECRUITINGJinan, 250103, China
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Dongguan People's Hospital
RECRUITINGGuangdong, 523000, China
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First Affiliated Hospital of Shandong First Medical University
RECRUITINGJinan, 250014, China
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Fujian Cancer Hospital
RECRUITINGFuzhou, 350014, China
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Guangxi Medical University Cancer Hospital
NOT_YET_RECRUITINGNanning, 541000, China
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Henan Cancer Hospital
RECRUITINGZhengzhou, 450052, China
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Hubei Cancer Hospital
RECRUITINGHubei, 430079, China
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Hunan Second People's Hospital
RECRUITINGChangsha, 410007, China
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Jiangxi Cancer Hospital
RECRUITINGJiangxi, 330029, China
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Nanjing Drum Tower Hospital
RECRUITINGJiangsu, 210008, China
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Peking University International Hospital
RECRUITINGBeijing, 100125, China
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Peking University Third Hospital
RECRUITINGBeijing, 100191, China
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Ruijin Hospital, Shanghai Jiaotong University School Of Medicine
RECRUITINGShanghai, 200025, China
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Shanghai Geriatric Medical Hospital
RECRUITINGShanghai, 201100, China
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Shanghai Pulmonary Hospital
RECRUITINGShanghai, 200433, China
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Shangxi Provincial Cancer Hospital
RECRUITINGTaiyuan, 030013, China
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The Affiliated Hospital of Qingdao University
RECRUITINGShandong, 266000, China
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The First Affiliated Hospital of Jinzhou Medical University
NOT_YET_RECRUITINGJinzhou, 121001, China
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The First Affiliated Hospital of Nanchang University
NOT_YET_RECRUITINGNanchang, 330000, China
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The First Affiliated Hospital of Sun Yat-sen University
RECRUITINGGuangzhou, 510062, China
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The First Affiliated Hospital of Xiamen University
RECRUITINGXiamen, 361102, China
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The First Affiliated Hospital of Zhengzhou University
NOT_YET_RECRUITINGZhengzhou, 450052, China
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The First Hospital of China Medical University
RECRUITINGShenyang, 110001, China
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The Fourth Hospital of Hebei Medical University
RECRUITINGShijiazhuang, 050011, China
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The History of Beijing Tiantan Hospital, Capital Medical University
RECRUITINGBeijing, 100070, China
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The Second Affiliated Hospital Zhejiang University School of Medicine
RECRUITINGZhejiang, 310009, China
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Zhejiang Cancer Hospital
RECRUITINGHangzhou, 310022, China
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Zhongshan Hospital Fudan University
NOT_YET_RECRUITINGShanghai, 200032, China
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