HEAD AND NECK CARCINOMA

This study tests a new type of radiation therapy (PULSAR) combined with advanced planning technology (HyperArc) for people with head and neck cancer who cannot have or choose not to have standard treatment. The goal is to see if this approach can better control tumors while causi…

This study tests a new approach for people with certain head and neck cancers: using lower doses of radiation and chemotherapy, followed by surgery to remove any remaining cancer in the neck. The goal is to see if this gentler treatment can still control the cancer while reducing…

This study tests an experimental drug called VMD-928, taken as a pill, either alone or with pembrolizumab (an immunotherapy), in adults with advanced solid tumors or lymphoma that have stopped responding to standard treatments. The goal is to find safe doses and see if the drug c…

This study tests whether giving antibiotics before surgery can lower the amount of bacteria found inside oral cancer tumors. About 30 adults with oral cancer will receive metronidazole and a special mouthwash before their planned surgery. Researchers will compare bacteria levels …

This study is for people whose head and neck cancer has come back after previous treatment. It tests a new combination of drugs (tislelizumab and pamiparib) given together with chemotherapy and a second round of radiation. The main goal is to find the safest dose and see if this …

This study tests a new vaccine designed to help the immune system fight HPV16, a virus linked to a type of throat cancer. The vaccine is given to patients who have already been treated for their cancer and show no signs of remaining disease. The goal is to find the safest dose th…

This study tests whether using a 3D virtual reality (VR) mindfulness program can help head and neck cancer patients and their caregivers feel less depressed, anxious, or in pain during radiation treatment. About 40 patients and their caregivers will try VR or a 2D activity and re…

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if patients prefer home care and if it is safe. Participants will receive their usual cancer drugs either at home or in the clini…

This study tests a simple technique called TORT where patients stick out their tongue during radiation for head and neck cancer. The goal is to see if this position lowers radiation to the tongue and throat muscles, reducing painful side effects like trouble swallowing, mouth sor…

This study tests a program called Financial Compass that helps head and neck cancer patients deal with money problems caused by their illness. About 50 patients will either get the program or usual care. The goal is to see if the program is practical and helpful, since financial …

This study looks at whether giving fluoride varnish during regular cancer follow-up visits can help improve oral health for head and neck cancer patients who have had radiation and lack easy access to dental care. About 120 uninsured or underinsured adults will take part. Researc…

This study tests whether custom 3D-printed oral stents can reduce mouth sores and blisters in people receiving radiation for head and neck cancer. About 119 adults will be randomly assigned to get radiation with or without the stent. The goal is to see if the stent makes treatmen…

This study tests whether a heavy lifting strength training program can help head and neck cancer survivors regain muscle strength, reduce fatigue, and improve quality of life. About 60 adults who finished cancer treatment at least one year ago will be randomly assigned to either …

This study looks for biological markers (biomarkers) in blood, tissue, and saliva that can show if a person has HPV-related throat cancer. Researchers will compare samples from 560 people with and without the disease. The goal is to improve how doctors detect and monitor this can…

This study will analyze cells and biomarkers from 50 adults newly diagnosed with head and neck cancer to understand what makes some cancers more aggressive. Participants must not have received prior treatment. The goal is to learn more about how the cancer behaves and progresses,…

This study aims to learn more about cancer genes in people from different ethnic backgrounds. Researchers will test 1,800 adults with various solid tumors to see how common certain gene changes are. The goal is to improve cancer risk assessment and tailor screening for these popu…

This study collects blood and tissue samples from 2000 people—some with cancer, some without—to help researchers develop and improve blood tests that can detect many types of cancer early. Participants provide samples that are stored and later used to test new diagnostic methods.…

This study gathers information on short- and long-term side effects from proton therapy in adults with various cancers. Researchers will collect data from up to 5,000 participants to better understand and predict these side effects. The goal is to improve future treatment plannin…