HEAD AND NECK CARCINOMA

This early-stage trial is testing a new combination of two experimental drugs, tislelizumab and pamiparib, given together with a standard course of chemotherapy and radiation. The goal is to find a safe and effective dose for people whose head and neck cancer has come back after …

This study is testing whether giving antibiotics and a special mouthwash before surgery can reduce the amount of bacteria inside oral cancer tumors. Researchers want to see if lowering these bacteria helps the body's immune system fight the cancer better. The trial involves 30 pa…

This early-stage study is testing a new oral drug called VMD-928, both by itself and combined with an existing immunotherapy (pembrolizumab). It is for adults with advanced solid tumors or lymphoma that have progressed despite available treatments. The main goals are to find safe…

This study is testing whether using a lower dose of radiation, combined with chemotherapy and planned surgery, can effectively control certain head and neck cancers. The goal is to see if this approach works while potentially reducing treatment side effects. It is for adults with…

This early-stage trial is testing a new therapeutic vaccine designed for people who have been treated for HPV-positive throat cancer and are currently cancer-free. The goal is to see if the vaccine is safe and can teach the body's immune system to recognize and attack any remaini…

This study compares two types of radiation therapy given after surgery for head and neck cancer. It tests whether a newer, more precise proton therapy works as well as standard X-ray therapy at keeping cancer from returning, while potentially causing fewer side effects like swall…

This study aims to collect blood and tissue samples to help develop a single blood test that can detect many different cancers early. Researchers will enroll 2,000 people, including those with cancer and those without, to create a reference set for testing. The goal is to validat…

This study is testing whether cancer patients prefer to receive their standard drug treatments at home instead of in a clinic. Researchers want to see if home-based care reduces the burden of travel and improves treatment satisfaction and quality of life for patients. A specializ…

This study is testing if a supervised heavy weight lifting program is practical and helpful for people who have survived head and neck cancer. It will compare 60 survivors doing 12 weeks of heavy lifting against a group receiving usual care. The main goal is to see if the program…

This study is testing a personalized, high-dose radiation schedule for people with advanced head and neck cancer who cannot have standard treatments. The goal is to see if this approach can shrink tumors more effectively and provide better pain and symptom relief, while aiming to…

This study is testing whether a new financial support program called 'Financial Compass' can help head and neck cancer patients who are struggling with money problems. Researchers want to see if this program works better than usual care at identifying and addressing financial har…

This study is testing whether using virtual reality (VR) headsets can help improve the mental and emotional well-being of people with head and neck cancer and their caregivers during difficult radiation or chemotherapy treatments. It will compare a more immersive 3D mindfulness p…

This study is testing if a simple change in patient positioning—sticking out the tongue during radiation therapy—can reduce severe side effects for people with head and neck cancer. Researchers believe this 'tongue-out' technique may lower radiation exposure to the tongue and thr…

This study is testing whether a custom-made, 3D-printed mouth guard can help reduce painful mouth sores and blisters in people receiving radiation therapy for head and neck cancers. About 119 patients will be randomly assigned to either use the guard during their standard radiati…

This study aims to find biological markers, or 'fingerprints,' in blood and saliva that can tell when a person has HPV-related throat cancer and when they don't. Researchers will collect samples from 440 people with and without head and neck cancers to compare. The goal is to dis…

This study collects detailed information about side effects experienced by cancer patients receiving proton radiation therapy. Researchers will follow 5,000 patients to understand both short-term and long-term effects, aiming to predict risks and improve safety for future patient…

This study aims to learn more about what makes head and neck cancer grow and come back. Researchers will collect tissue and blood samples from 50 newly diagnosed patients who have not yet started treatment. By analyzing these samples, they hope to find biological markers that cou…

This study aims to understand how cancer-related genetic mutations differ among various ethnic populations. Researchers will collect blood or saliva samples from 1,800 cancer patients from diverse backgrounds to identify genetic patterns. The findings could help create more perso…